پنجشنبه 30 فروردین 1403
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دوره 15، شماره 5 - ( 3-1396 )
جلد 15 شماره 5 صفحات 272-265 |
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Gholami M, Ahmadi S A Y, Abaszadeh A, Khaki A. Protective effects of melatonin and ghrelin on spermatogenesis: A narrative review of the literature. IJRM 2017; 15 (5) :265-272
URL: http://ijrm.ir/article-1-826-fa.html
URL: http://ijrm.ir/article-1-826-fa.html
غلامی محمّدرضا، احمدی سیّدامیر یاسین، عبّاس زاده ابوالفضل، خاکی آرش. مروری بر آثار حفاظت‌کننده ملاتونین و گرلین بر اسپرماتوژنزیز: یک روایت مروری. International Journal of Reproductive BioMedicine. 1396; 15 (5) :265-272
1- گروه علوم تشریحی، دانشکده پزشکی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
2- کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی لرستان، خرم آباد، ایران
3- گروه جرّاحی، دانشگاه علوم پزشکی لرستان، خرم‌آباد، ایران
4- گروه علوم پاتولوژی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران ، khaki@iaut.ac.ir
2- کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی لرستان، خرم آباد، ایران
3- گروه جرّاحی، دانشگاه علوم پزشکی لرستان، خرم‌آباد، ایران
4- گروه علوم پاتولوژی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران ، khaki@iaut.ac.ir
چکیده: (3539 مشاهده)
فرایند اسپرماتوژنز از لومن لولههای اسپرمساز در قاعدهی این لولهها آغاز شده و پس از مهاجرت به غشای پایه مجدّداً در لومن خاتمه مییابد. ما برآن بودیم تا آثار محافظ کنندهی هرمونهای ملاتونین و گرلین را بر فرایند اسپرماتوژنز و بهخصوص بر سلولهای بنیادی اسپرماتوگونی (SSC) به عنوان دو هرمون بهنسبت نوظهور بررسی کنیم. از راههای حفظ باروری در کودکان مبتلا به سرطان که مورد شیمیدرمانی و پرتودرمانی قرار میگیرند، استفاده از فرایند انجماد است. این انجماد دارای دو روش انجماد آهسته (cryopreservation) و انجماد سریع (vitrification) است. مداخلهی ملاتونین میتواند موجب حفظ کیفیت اسپرمهایی که انجماد برروی آنها ایجاد شده بود، گردد؛ همانطوری که گرلین نیز از سلولهای جنسی در برابر سمیّتهای ناشی از آسیبهای ایسکمیک و اپوپتوز پاتولوژیک محافظت میکند. مرور حاضر نشان میدهد که مداخلهی in-vitro و in-vivo ملاتونین و گرلین میتواند برحفاظت از باروری در چنین شرایطی مؤثّر باشد و نیز میتواند به منظور بهبود کیفیت اسپرمها در فنآوری کمک باروری استفاده گردد. پیشنهاد میگردد مقالات پژوهشی اصیل دراین حوزه به سمت مطالعات انسانی و البته با رعایت اخلاق در پژوهش سوق داده شوند.
نوع مطالعه: Original Article |
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