دوره 15، شماره 6 - ( 4-1396 )                   جلد 15 شماره 6 صفحات 344-331 | برگشت به فهرست نسخه ها

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Pourmasumi S, Sabeti P, Rahiminia T, Mangoli E, Tabibnejad N, Talebi A R. The etiologies of sperm DNA abnormalities in male infertility: An assessment and review. IJRM 2017; 15 (6) :331-344
URL: http://ijrm.ir/article-1-834-fa.html
پورمعصومی سهیلا، پروین پروین، رحیمی نیا طاهره، منگلی عصمت، طبیب نژاد نسیم، طالبی علیرضا. ارزیابی و بررسی علل غیرطبیعی بودن کروماتین و DNA اسپرم در ناباروری با علت مردانه. International Journal of Reproductive BioMedicine. 1396; 15 (6) :331-344

URL: http://ijrm.ir/article-1-834-fa.html

ارزیابی و بررسی علل غیرطبیعی بودن کروماتین و DNA اسپرم در ناباروری با علت مردانه
سهیلا پورمعصومی* 1، پروین پروین1 ، طاهره رحیمی نیا1 ، عصمت منگلی1 ، نسیم طبیب نژاد1 ، علیرضا طالبی1
1- مرکز تحقیقاتی و درمانی ناباروری،پژوهشکده علوم تولیدمثل، دانشگاه علوم پزشکی شهید صدوقی، یزد، ایران
چکیده:   (6878 مشاهده)
آسیب کروماتین و DNA اسپرم ممکن است در بیضه، مجراهای تناسلی و همچنین پس از انزال رخ دهد. مکانیزم تغییر در ساختار کروماتین و آپوپتوز نافرجام و استرس اکسیداتیو ناشی از گونه های اکسیژن فعال (ROS) می­باشد. عوامل داخل بیضه­ای، پس از بیضه و عوامل خارجی با افزایش سطح آسیب به DNA اسپرم انسان می­تواند احتمال باروری را تحت تأثیر قرار دهد. شیوه زندگی، محیط زیست، پزشکی و عوامل درمانزاد ممکن است به عنوان عوامل تخریب کننده در نظر گرفته شوند که باعث اختلالات اندوکرین می­شوند. در نتیجه، این تغییرات ممکن است با تأثیر مخرب بر کروماتین /DNA در سلول­های زایا، در میان   نسل­ها انتقال پیدا کنند و باعث با عواقب فنوتیپی گردند. میزان هیستون باقی مانده و کمبود پروتامین ممکن است با مصرف الکل در اسپرم افزایش نیابد. با این حال، باعث افزایش درصد اسپرم با DNA قطعه قطعه شده و آپوپتوز در اسپرم می­شود. آسیب نخاعی به عنوان یک مشکل پزشکی، می تواند پارامترهای اسپرم را تضعیف کرده و باعث آسیب قابل توجه DNA دراسپرم در این مردان شود. همچنین عفونت می­تواند تولید ROS را افزایش دهد و، کاهش ظرفیت آنتی اکسیدانی و قطعه قطعه شدن DNA اسپرم و یا تولید آنتی ژن که منجر به اختلالات اسپرم و قطعه قطعه شدن DNA می­گردد را را القا کند. در حالی که ROS با افزایش سن افزایش می یابد و استرس اکسیداتیو ممکن است مسئول آسیب DNA اسپرم وابسته به سن مردان مسن تر نسبت به جوان ترها باشد. بررسی کیفیت کروماتین اسپرم درموارد سرطان بیضه و بیماران مبتلا به لنفوم هوچکین قبل از شیمی درمانی شیوع بالای آسیب به DNA و تراکم کم درکروماتین اسپرم در زمان تشخیص را نشان داده است. در سیکل شیمی درمانی با عوامل ژنوتوکسیک در بیماران مبتلا به سرطان، افزایش آسیب DNA اسپرم بعد از درمان نشان نیزداده شد. بطور کلی فاکتورهایی که باعث تغییر توزیع پروتئین در کروماتین اسپرم می گردد می توانند در دوران جنینی و یا بزرگسالی بر سلولهای زایای اسپرم ساز تاثیر بگذارند که ناباروری را در بیماران القا کند.
واژه‌های کلیدی: اسپرم، کروماتین، ابنورمالیتی DNA، ناباروری مردانه، گونه فعال اکسیژن.
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