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Volume 15, Issue 11 (11-2017)
IJRM 2017, 15(11): 729-734 |
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Marsoosi V, Pirjani R, Jafarabadi M A, Mashhadian M, Ziaee S, Moini A. Cervical gland area as an ultrasound marker for prediction of preterm delivery: A cohort study. IJRM 2017; 15 (11) :729-734
URL: http://ijrm.ir/article-1-905-en.html
URL: http://ijrm.ir/article-1-905-en.html
Vajiheh Marsoosi1 
, Reihaneh Pirjani * 2, Mohamad Asghari Jafarabadi3 , Mina Mashhadian4 , Saeedeh Ziaee5 , Ashraf Moini6
, Reihaneh Pirjani * 2, Mohamad Asghari Jafarabadi3 , Mina Mashhadian4 , Saeedeh Ziaee5 , Ashraf Moini6
1- Perinatology Division, Obstetrics and Gynecology Department, Tehran University of Medical Sciences, Tehran, Iran
2- Obstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran ,pirjani@razi.tums.ac.ir
3- Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4- Islamic Azad University, Maybod, Iran
5- Tarbiat Modaress University of Medical Sciences, Tehran, Iran.
6- Obstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Obstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran ,
3- Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4- Islamic Azad University, Maybod, Iran
5- Tarbiat Modaress University of Medical Sciences, Tehran, Iran.
6- Obstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract: (3702 Views)
Background: Preterm labor is a major cause of perinatal morbidity and mortality and it might be predicted by assessing the cervical change.
Objective: To assess the association between absence of cervical gland area (CGA) and spontaneous preterm labor (SPTL).
Materials and Methods: This prospective cohort study was performed on 200 singleton pregnant women with a history of SPTL, second-trimester abortion in the previous pregnancy or lower abdominal pain in current pregnancy. Each patient underwent one transvaginal ultrasound examination between 14-28 wk of gestation. Cervical length was measured and CGA was identified and their relationship with SPTL before 35 and 37 wk gestation was evaluated using STATA software version 10.
Results: The mean of cervical length was 36.5 mm (SD=8.4), the shortest measurement was 9 mm, and the longest one was 61 mm. Short cervical length (≤18mm) was significantly associated with SPTL before 35 and 37 wk gestation. Cervical gland area (the hypoechogenic or echogenic area around the cervical canal) was present in 189 (94.5%) patients. Absent of CGA had a significant relationship with SPTL before 35 and 37 wk gestation (p=0.01 and p<0.001, respectively). Cervical length was shorter in women with absent CGA in comparison with subjects with present CGA: 37±10 mm in CGA present group and 23±9 mm in CGA absent group (p<0.001).
Conclusion: Our study showed that cervical gland area might be an important predictor of SPTL which should be confirmed with further researches.
Objective: To assess the association between absence of cervical gland area (CGA) and spontaneous preterm labor (SPTL).
Materials and Methods: This prospective cohort study was performed on 200 singleton pregnant women with a history of SPTL, second-trimester abortion in the previous pregnancy or lower abdominal pain in current pregnancy. Each patient underwent one transvaginal ultrasound examination between 14-28 wk of gestation. Cervical length was measured and CGA was identified and their relationship with SPTL before 35 and 37 wk gestation was evaluated using STATA software version 10.
Results: The mean of cervical length was 36.5 mm (SD=8.4), the shortest measurement was 9 mm, and the longest one was 61 mm. Short cervical length (≤18mm) was significantly associated with SPTL before 35 and 37 wk gestation. Cervical gland area (the hypoechogenic or echogenic area around the cervical canal) was present in 189 (94.5%) patients. Absent of CGA had a significant relationship with SPTL before 35 and 37 wk gestation (p=0.01 and p<0.001, respectively). Cervical length was shorter in women with absent CGA in comparison with subjects with present CGA: 37±10 mm in CGA present group and 23±9 mm in CGA absent group (p<0.001).
Conclusion: Our study showed that cervical gland area might be an important predictor of SPTL which should be confirmed with further researches.
Type of Study: Original Article |
References
1. Gilbert WM. The cost of preterm birth: the low cost versus high value of tocolysis. BJOG 2006; 113 (Suppl. 3): 4-9. [DOI:10.1111/j.1471-0528.2006.01117.x]
2. Khoshnood Shariati M, Karimi Z, Rezaienejad M, Basiri A, Torkestani F, Saleh Gargari S. Perinatal complications associated with preterm deliveries at 24 to 33 weeks and 6 days gestation (2011-2012): A hospital-based retrospective study. Iran J Reprod Med 2015; 13: 697-702.
3. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84. [DOI:10.1016/S0140-6736(08)60074-4]
4. Marlow N, Wolke D, Bracewell MA, Samara M. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med 2005; 352: 9-19. [DOI:10.1056/NEJMoa041367]
5. Callaghan WM, MacDorman MF, Rasmussen SA, Qin C, Lackritz EM. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics 2006; 118: 1566-1573. [DOI:10.1542/peds.2006-0860]
6. Dalili M, Karimzadeh Meybodi MA, Ghaforzadeh M, Farajkhoda T, Molavi-E Vardanjani H. Screening of preterm labor in Yazd city: transvaginal ultrasound assessment of the length of cervix in the second trimester. Iran J Reprod Med 2013; 11: 279-284.
7. Feltovich H, Ji H, Janowski JW, Delance NC, Moran CC, Chien EK. Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term. Am J Obstet Gynecol 2005; 192: 753-760. [DOI:10.1016/j.ajog.2004.12.054]
8. McFarlin BL, Bigelow TA, Laybed Y, O'Brien WD, Oelze ML, Abramowicz JS. Ultrasonic attenuation estimation of the pregnant cervix: a preliminary report. Ultrasound Obstet Gynecol 2010; 36: 218-225. [DOI:10.1002/uog.7643]
9. Sekiya T, Ishihara K, Yoshimatsu K, Fukami T, Kikuchi S, Araki T. Detection rate of the cervical gland area during pregnancy by transvaginal sonography in the assessment of cervical maturation. Ultrasound Obstet Gynecol 1998; 12: 328-333. [DOI:10.1046/j.1469-0705.1998.12050328.x]
10. Kahyaoglu S, Kahyaoglu I, Kaymak O, Sagnic S, Mollamahmutoglu L, Danisman N. Can transvaginal ultrasonographic evaluation of the endocervical glandular area predict preterm labor among patients who received tocolytic therapy for threatened labor: a cross-sectional study. J Matern Fetal Neonatal Med 2013; 26: 920-925. [DOI:10.3109/14767058.2013.766703]
11. Yamaguchi M, Fukami T, Asakura H, Takeshita T. Predicting onset of labor from echogenicity of the cervical gland area on vaginal ultrasonography at term. J Perinat Med 2015; 43: 577-584. [DOI:10.1515/jpm-2014-0080]
12. To MS, Skentou C, Liao AW, Cacho A, Nicolaides KH. Cervical length and funneling at 23 weeks of gestation in the prediction of spontaneous early preterm delivery. Ultrasound Obstet Gynecol 2001; 18: 200-203. [DOI:10.1046/j.1469-0705.2001.00437.x]
13. Fukami T, Ishihara K, Sekiya T, Araki T. Is transvaginal ultrasonography at mid-trimester useful for predicting early spontaneous preterm birth? J Nihon Med Sch 2003; 70: 135-140. [DOI:10.1272/jnms.70.135]
14. Asakura H, Fukami T, Kurashina R, Tateyama N, Doi D, Takeshita T. Significance of cervical gland area in predicting preterm birth for patients with threatened preterm delivery: comparison with cervical length and fetal fibronectin. Gynecol Obstet Invest 2009; 68: 1-8. [DOI:10.1159/000209394]
15. Pires CR, Moron AF, Mattar R, Diniz AL, Andrade SG, Bussamra LC. Cervical gland area as an ultrasonographic marker for preterm delivery. Int J Gynaecol Obstet 2006; 93: 214-219. [DOI:10.1016/j.ijgo.2005.12.010]
16. Yoshimatsu K, Sekiya T, Ishihara K, Fukami T, Otabe T, Araki T. Detection of the cervical gland area in threatened preterm labor using transvaginal sonography in the assessment of cervical maturation and the outcome of pregnancy. Gynecol Obstet Invest 2002; 53: 149-156. [DOI:10.1159/000058366]
17. Guzman ER, Walters C, Ananth CV, O'Reilly-Green C, Benito CW, Palermo A, et al. A comparison of sonographic cervical parameters in predicting spontaneous preterm birth in high-risk singleton gestations. Ultrasound Obstet Gynecol 2001; 18: 204-210. [DOI:10.1046/j.0960-7692.2001.00526.x]
18. Hassan SS, Romero R, Berry SM, Dang K, Blackwell SC, Treadwell MC, et al. Patients with an ultrasonographic cervical length < or =15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 2000; 182: 1458-1467. [DOI:10.1067/mob.2000.106851]
19. Heath VCF, Southall TR, Souka AP, Elisseou A, Nicolaides KH. Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery. Ultrasound Obstet Gynecol 1998; 12: 312-317. [DOI:10.1046/j.1469-0705.1998.12050312.x]
20. Andersen HF, Nugent CE, Wanty SD, Hayashi RH. Prediction of risk for preterm delivery by ultrasonographic measurement of cervical length. Am J Obstet Gynecol 1990; 163: 859-867. [DOI:10.1016/0002-9378(90)91084-P]
21. Guzman ER, Mellon C, Vintzileos AM, Ananth CV, Walters C, Gipson K. Longitudinal assessment of endocervical canal length between 15 and 24 weeks' gestation in women at risk for pregnancy loss or preterm birth. Obstet Gynecol 1998; 92: 31-37. [DOI:10.1016/S0029-7844(98)00120-3]
22. Parra-Saavedra M, Gómez L, Barrero A, Parra G, Vergara F, Navarro E. Prediction of preterm birth using the cervical consistency index. Ultrasound Obstet Gynecol 2011; 38: 44-51. [DOI:10.1002/uog.9010]
23. Marsoosi V, Jamal A, Eslamian L. Pre-pregnancy weight, low pregnancy weight gain, and preterm delivery. Int J Gynaecol Obstet 2004; 87: 36-37. [DOI:10.1016/j.ijgo.2004.06.002]
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