Showing 6 results for Ghiasvand
Tayebeh Ghiasvand, Mohammad Taghi Goodarzi, Gholamreza Shafiee, Alireza Zamani, Jamshid Karimi, Marzieh Ghorbani, Iraj Amiri,
Volume 16, Issue 2 (February 2018)
Abstract
Background: Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays a role in the etiology of male infertility. Increased reactive oxygen species is accompanied with increase in neopterin level. Hence neopterin may be involved in male infertility.
Objective: The objective of this case-control study was to determine neopterin level in idiopathic infertile and normospermic men; furthermore, to identify its relationship with oxidative stress markers including total oxidant, malondialdehyde, sperm DNA fragmentation, and total antioxidant capacity of seminal plasma.
Materials and Methods: Forty seven infertile and forty three normospermic males were selected according to WHO criteria. Their semen and blood samples were taken; subsequently, the levels of neopterin, total oxidant, total antioxidant, malondialdehyde, and sperm DNA fragmentation were measured.
Results: The levels of neopterin, total oxidant, and malondialdehyde in seminal plasma of infertile males were significantly higher than those of normospermic group (p=0.038, 0.018, and 0.028, respectively). Furthermore, sperm DNA fragmentation in infertile men was higher than that of control group (p<0.001). Moreover, total antioxidant capacity of seminal plasma in infertile males was significantly lower than that of normospermic subjects (p=0.002). No significant difference was observed in serum neopterin, total oxidant, and malondialdehyde between the infertile and normospermic groups.
Conclusion: The significant inverse correlation between seminal plasma neopterin and total antioxidant in the infertile males supports a possible role of neopterin in male infertility. Neopterin can be suggested as a marker in monitoring and diagnosis of idiopathic male infertility.
Haeri F, Shirani M, Nouri M, Dehghan Marvast L, Ghiasvand R,
Volume 19, Issue 5 (Suppl- 2021)
Abstract
Background: Some epidemiological studies have reported a relationship between infertility and lifestyle patterns including dietary habits.
Objective: Our objective was to identify the relation between sperm parameters and dietary fatty acid and mineral intake among Iranian infertile men.
Materials and Methods: This cross sectional was performed on 400 newly diagnosed infertile men in Yazd Reproductive Sciences Institute from July to December 2019. Men were recruited when their infertility was confirmed by the expert andrologist based on World Health Organization criteria. They delivered a semen sample and answered a 168 items semiquantitative food frequency questionnaire. All data were analyzed using SPSS V. 22 software. P-value less than 0.5 considered as significant.
Results: We found a positive association between poly-unsaturated fatty acid intake, total motility, and normal morphology (p = 0.03). Also, there was a significant negative association between the second quartile of sodium and calcium intake and sperm volume (ptrend: 0.04), compared with the first quartile.
Conclusion: We concluded that dietary of poly-unsaturated fatty acid intake, sodium and calcium intake are related to sperm morphology, volume and total motility in Iranian infertile men. However, more research is needed to confirm these relations and provide the evidence needed to exert these findings into clinical practice.
Haeri F, Shirani M, Shariatpanahi Sp, Dehghan Marvast L, Ghiasvand R,
Volume 19, Issue 5 (Suppl- 2021)
Abstract
Background: Infertility had an increasing trend between couples in the world. Several factors such as unhealthy dietary habits are associated with sperm abnormality.
Objective: This study was conducted to investigate the association between food groups intake and sperm variables in men referring to an Iranian Reproductive Sciences Institute.
Materials and Methods: 400 infertile Men 20-55 yr of age admitted to an Iranian Reproduction Research Institute, were selected for this cross-sectional study according to the World Health Organization Fifth Edition Laboratory Guidelines. Usual dietary intake was collected by using a 168 items semiquantitative food frequency questionnaire. The relationship between food groups and sperm factors was measured by a multiple linear regression model while other confounding variables were adjusted. All data were analyzed using SPSS V. 22 software. P-value less than 0.5 considered as significant.
Results: According to this study, after adjusting for potential confounders, there was a significant relationship between sperm count with refined grains and soft drink, a significant association between normal morphology with whole grains, low-fat dairy intake and fruit, semen volume is significantly related to red meat intake, low-fat dairy, fruit and tea intake and progressive motility had a significant association between progressive motility with whole grains, low-fat dairy, fruit, soft drink and coffee intake (p-trend < 0.05).
Conclusion: We concluded that there is a relationship between grains, dairy, fruits, meat, caffeine and tea dietary intake with sperm parameters, which are sometimes in line or in contradiction with the results of previous studies.
Khadijeh Baranizadeh, Maryam Bahmanzadeh, Heidar Tavilani, Tayebeh Ghiasvand, Iraj Amiri, Mahnaz Yavangi, Gholamreza Shafiee,
Volume 20, Issue 4 (April 2022)
Abstract
Background: Methylenetetrahydrofolate reductase enzyme (MTHFR) plays a key role in regulating folate balance, converting homocysteine to methionine, and producing s-adenosylmethionine (SAM) that plays a role in the methylation process.
Objective: This study aimed to determine MTHFR activity and SAM level in men with normozoospermia and oligozoospermia.
Materials and Methods: 30 oligozoospermic and 30 normozoospermic men as controls were enrolled in this case-control study. Semen analysis was conducted according to the world health organization criteria. All semen samples were collected after 3-5 days of sexual abstinence. The sperms were evaluated by sperm test video software. All subjects SAM level was measured by enzyme-linked immunosorbent assay kit, and MTHFR were measured manually.
Results: 2 groups had a significant difference in sperm morphology (p = 0.02), concentration (p = 0.02) and motility (p = 0.03). The MTHFR activity in normozoospermic and oligozoospermic groups had significantly differences (p = 0.01). The level of SAM in the semen of oligozoospermic men was statistically lower than normozoospermic men (p = 0.03). Also, there was a positive association between MTHFR enzyme activity and SAM level in the normozoospermia group (p = 0.02, β = 0.67) and oligozoospermia group (p = 0.03, β = 0.54).
Conclusion: MTHFR activity and SAM concentration were statistically lower in oligozoospermia men. It seems they can affect sperm concentration, morphology, and motility.
Hamid Norioun, Seyed Jamal Moshtaghian, Firoozeh Alavian, Maryam Khombi Shooshtari, Golnaz Alipour, Saeedeh Ghiasvand,
Volume 22, Issue 7 (July 2024)
Abstract
Background: Opioid analgesics like morphine and methadone are widely used for managing severe pain; however, concerns over their potential misuse and adverse effects on the brain and reproductive system are significant.
Objective: We aimed to investigate their impacts on spermatogenesis and cognitive function in male Norway rats.
Materials and Methods: In this experimental study, 36 male Norway rats (250-300 gr, 6 months old) were divided into 6 groups: low-dose morphine, high-dose morphine, low-dose methadone, high-dose methadone, positive control (received normal saline at 5 mg/kg), and negative control (received no treatment). Morphine and methadone were administered intraperitoneally over 30 days at doses of 3 mg/kg and 7 mg/kg, respectively. Behavioral assessments evaluated anxiety, stress, and short- and long-term memory. Sperm parameters (viability, motility, morphology), hormonal analysis (testosterone, luteinizing hormone, follicle-stimulating hormone, estradiol), and gene expressions (Tp53, CatSper1) were assessed.
Results: A significant reduction in rat weight was observed in the high-dose morphine group (p = 0.0045), while testicular weights remained unchanged. Sperm abnormalities were observed with high doses of methadone and morphine. High-dose methadone significantly reduced offspring count (p = 0.0004). Levels of follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol varied significantly across treatment groups. Gene expression was altered in response to treatments (p < 0.05).
Conclusion: Prolonged exposure to methadone and morphine resulted in memory dysfunction, chronic stress, hormonal disturbances, altered gene expression, and fertility complications. These effects were more pronounced at higher doses, highlighting the importance of careful dosage management in opioid therapy.
Hamid Norioun , Seyed Jamal Moshtaghian , Firoozeh Alavian , Maryam Khombi Shooshtari , Golnaz Alipour , Saeedeh Ghiasvand ,
Volume 22, Issue 10 (October 2024)
Abstract
The publisher has been informed of an error that occurred on page 579 in which the last authors affiliation must be changed to Department of Biology, Faculty of Sciences, Malayer University, Malayer, Iran. On behalf of the author, the publisher wishes to apologize for this error. The online version of the article has been updated on October 31, 2024 and can be found at https://doi.org/10.18502/ijrm.v22i7.16971.
