Showing 5 results for Poordast
Fatemesadat Najib, Tahereh Poordast, Mina Rezvan Nia, Mohammad Hossein Dabbaghmanesh,
Volume 18, Issue 1 (January 2020)
Abstract
Abstract
Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).
Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.
Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100µg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.
Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).
Conclusion: The results of this trial suggest that supplementation with 100µg of selenium does not modulate glucose homeostasis in women with GDM.
Elham Askary, Tahereh Poordast, Zahra Shiravani, Mohammad Ali Ashraf, Atefeh Hashemi, Razieh Naseri, Shaghayegh Moradialamdarloo, Zinat Karimi, Elham Izanloo, Fatemeh Sadat Najib,
Volume 19, Issue 2 (February 2021)
Abstract
Background: Coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the susceptibility amongst different groups of the population. Pregnant women are one such group. This study was conducted to investigate the effect of COVID-19 on pregnancy and maternal/neonatal outcomes.
Case presentation: This case series was conducted on 16 pregnant women with COVID-19 from March 21 to May 11, 2020. Clinical characteristics, pregnancy complications, medication used, maternal/neonatal outcomes, and fatality rate were investigated through this study. The mean age of the patients was 30.06 yrs. Patients from all three trimesters were included (1 in first, 5 in second, and 10 in the third trimesters). The most common clinical symptoms were shortness of breath (n = 10), dry cough (n = 10), myalgia (n = 8), and chills (n = 7). Also, three cases had papulosquamous skin lesions with fissuring. The most common laboratory results were leukocytosis (n = 8), increased liver enzymes (n = 6), elevated CRP (n = 5), and thrombocytopenia (n = 4). There was one case of maternal mortality, five of premature labor pain (PLP), two of preeclampsia, and two of placenta accreta. Twelve pregnancies were terminated (nine cesarean sections, three vaginal deliveries). Among neonates, we had 6 cases of preterm labor. All neonates had negative PCR results.
Conclusion: Clinical manifestations and paraclinical results were similar to non-pregnant patients. There was no evidence of vertical transmission. PLP and premature rupture of membranes (PROM) were the most common complications in the second and third trimesters of pregnant COVID-19 women, which can lead to rupture of the uterus. Termination and delivery should be planned individually.
Alborzi S, Askary A, Khorami F, Poordast T, Abdulwahid Hashim Alkhalidi B, Hamedi M, Alborzi S, Raeisi Shahraki H,
Volume 19, Issue 5 (Suppl- 2021)
Abstract
Background: Endometriosis and adenomayosis are common gynecological disorders and in this work we want to evaluate the co-existence of these two diseases.
Objective: The current study was designed to evaluate the relationship between adenomyosis and its subtypes with endometriotic lesions ovarian endometrioma (OMAs) along with the posterior deep infiltrative endometriosis (DIE). We also examined the the accuracy, sensitivity, and specificity of both transvaginal sonography (TVS) and magnetic resonance imaging (MRI) in diagnosis of adenomyotic uterus.
Materials and Methods: In this retrospective cross-sectional study, we selected 154 women with coexistence of endometriosis and adenomyosis according to their imaging, intra operative or pathological findings who were nominated for laparoscopic surgery. Eighty-six patients undergoing DIE resection without laparoscopic hysterectomy (group 1), and 68 patients with laparoscopic hysterectomy plus DIE resection (group 2).
Results: The accuracy, sensitivity and specificity of ultrasonographic and MRI findings for adenomyosis diagnosis were 72.1%, 77.6%, 40.0% and 49.2%, 41.5%, 90.0% respectively. Therefore TVS was more sensitive diagnostic tool for detecting adenomyosis, however, MRI was more specific than TVS in diagnosis of diffuse adenomyosis especially with simultaneous presence of uterine leiomyoma. Regarding the association of different types of adenomyosis (focal and diffuse) with different endometriosis lesions (OMA and posterior compartment DIE), we found that diffuse type of adenomyosis is more frequent in the absence of rectal and rectovaginal septum DIE (p ≤ 0.05).
Conclusion: In addition to the questionable different nature of rectal and rectovaginal septum DIE lesion, there is no relationship between adenomyosis subtypes and endometriotic lesions.
Zahra Shiravani, Sana Atbaei, Bahia Namavar Jahromi, Mojgan Hajisafari Tafti, Shaghayegh Moradi Alamdarloo, Tahereh Poordast, Adel Noori, Sedighe Forouhari, Soudabeh Sabetian,
Volume 20, Issue 3 (March 2022)
Abstract
Background: Ectopic pregnancy (EP) is one of the major causes of maternal mortality during the first trimester of pregnancy.
Objective: Four treatment methods for EP including single-dose methotrexate (SD-MTX), double-dose methotrexate, expectant and surgical management were considered.
Materials and Methods: In this cross-sectional study, the clinical characteristics of 365 women aged 15-44 yr who had been diagnosed with EP were reviewed from March 2017 to March 2019 in hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Receiver operating characteristics curves were plotted to determine the cut-off points for size of ectopic mass and beta-human chorionic gonadotropin (β-hCG) that suitably discriminated between double-dose methotrexate and surgery management.
Results: The most common site of EP was adnexa. According to the receiver operating characteristics analysis, surgery was the best plan for the women with an ectopic mass > 34.50 mm in diameter or with an initial β-hCG level > 6419 mIU/ml. The β-hCG levels in the women successfully treated with SD-MTX were significantly lower than in those with failed treatment (p = 0.02). The SD-MTX group had a higher success rate and significantly shorter duration of hospitalization, and so this was a more effective medical treatment in comparison with the DD protocol.
Conclusion: Surgery is proposed as the best option for the cases with large ectopic mass or high β-hCG level. SD-MTX had a higher success rate and shorter hospital stay than the DD protocol, and so was found to be an efficient and safe alternative. Further randomized clinical trials with larger sample sizes are recommended to validate the current results.
Tahereh Poordast, Saeed Alborzi, Ziba Kiani, Navid Omidfar, Elham Askary, Kefayat Chamanara, Mansoureh Shokripour, Alimohammad Keshtvarz Hesam Abadi,
Volume 22, Issue 7 (July 2024)
Abstract
Background: The lack of improvement in some endometriotic people’s pain after surgery even while using hormone treatment may suggest an inappropriate response to routine hormonal therapies.
Objective: This study aimed to determine a cut-off point for selecting the most appropriate treatment based on the hormone receptors of endometriotic lesions.
Materials and Methods: In this cross-sectional study, by reviewing the medical records of participants and testing their archive samples and phone interviews (if needed), 86 symptomatic women after endometriosis surgery who were operated into governmental hospitals, Shahid Faghihi and Hazrate Zeinab Shiraz Iran were enrolled between March 2017 and March 2019. Women were divided into 2 groups: responsiveness (n = 73 for dysmenorrhea, n = 60 for dyspareunia) to medical treatment and surgery, and unresponsiveness (n = 13, n = 7). We examined the pathological slides of 86 women to determine the amount of hormone receptors and the relationship between the type of medical treatment and the level of hormone receptors on pain relief within 1 yr after surgery.
Results: Based on the receiver operating characteristic curve, dysmenorrhea in the presence of tissue estrogen receptors > 60% (p = 0.1065), and dyspareunia in the presence of tissue progesterone receptors > 80% (p = 0.0001) responded well to medical treatment after surgery. In the presence of endometrioma-dysmenorrhea showed the best response to oral contraceptive pills (69.4%), while in deep infiltrative endometriosis-dyspareunia showed the best response to progesterone treatment (75%).
Conclusion: Prescribing an appropriate hormone therapy based on a specific immunohistochemistry staining pattern can improve the life quality of postoperative endometriosis individuals.
