Showing 11 results for Infertile
Hossein Hadinedoushan, Mohammad Ghafourzadeh,
Volume 5, Issue 2 (7-2007)
Abstract
The presence of anti-sperm antibodies (ASA) in semen or serum may impair sperm function leading to immunological infertility. The aim of this study was to investigate the presence of ASA on the surface of sperm and in circulating blood of infertile couples. In this cross sectional study, we studied 49 couples suffering from infertility for at least one year. Serum ASA (IgG and IgA classes) was examined by indirect SpermMAR test. Also, ASA (IgG and IgA classes) attached to the surface of spermatozoa were tested by direct SpermMAR method in ejaculates from infertile men. ASA were positive in 8% of semen samples (2% IgG, 4% IgA, 2% both IgG and IgA classes). Only in one woman, ASA of the IgG class was found in serum samples. The presence of ASA may impair fertilizing ability and is a serious factor which may prevent the success of various fertilization techniques. ASA assessment should be considered as an essential part of infertility management.
Mohammad Hossein Baghiani Moghadam, Amir Hosein Aminian, Ali Mohammad Abdoli, Najmeh Seighal, Hosein Falahzadeh, Nasrin Ghasemi,
Volume 9, Issue 4 (7-2011)
Abstract
Background: The prevalence of infertility is variable between 5-30% around the world. In Iran, more than 2 million couples suffer from infertility. Infertility causes depression, anxiety, social isolation and sexual dysfunction.
Objective: This descriptive study was undertaken to determine general health in infertile couples.
Materials and Methods: One hundred and fifty infertile couples attending Yazd Research and Clinical Center for Infertility were randomly selected during March till September 2009. The GHQ-28 questionnaires were completed by researchers, based on face to face interview. It contains 28 items, which have been divided to four sub- items. The results come out by scoring the patients answer from 0 to 84. All data were analyzed by Chi-square and t-test in SPSS software.
Results: GHQ scores of all sub-scales and total in women were more than men, which shows general health condition in women is worse than men. There was no relation between the duration of infertility and general health scores.
Conclusion: This study suggests that the infertility has significant effect (p=0.001) on health situation of infertile couples, especially infertile women. They are at risk of somatic symptoms (p=0.0001), social dysfunction (p=0.0001) and severe depression (p=0.0001). GHQ could provided help and support in order to improve the health situation of infertile couples.
Cyrus Azimi, Malihea Khaleghian, Farideh Farzanfar,
Volume 11, Issue 4 (6-2013)
Abstract
Background: The infertility is an important health problem, affecting about 15% of couples. The important role of genetic factors in pathogenesis of infertility is now increasingly recognized. The value of karyotyping women in the routine work-out of couples referred for sterility has long been recommended.
Objective: The aim of this study was to define the frequency of all chromosomal aberrations among women which referred to our department due to infertility during the 21-year period.
Materials and Methods: In this 21-year retrospective study, for the first time, we investigated 896 women which referred to our department due to infertility during 1986 to 2006. For chromosome analysis, heparinized peripheral blood samples were cultured, harvested and banded according to standard methods.
Results: Out of 896 patients, 710 patients (79.24%) had a normal karyotype, and 186 patients (20.76%) showed abnormal karyotype. Among the abnormal ones 48 patients (25.81%) showed Turner's syndrome (45,X), and 45 patients (24.19%) were sex reversal with 46,XY karyotype. The rest of 93 patients (50%) revealed a wide range of chromosome abnormalities.
Conclusion: Our results emphasized the importance of the standard cytogenetic methods in assessing the genetic characteristics of infertile females, which allows detecting a variety of somatic chromosome abnormalities, because some of these may interfere with the success of reproduction.
Mahnaz Mansouri Torshizi, Amir Reza Khalighi, Mahla Fadavi Islam, Rahele Aram, Elham Sabouri, Hekmat Khalilifar, Hesam Roustaee,
Volume 12, Issue 1 (2-2014)
Abstract
Background: Human T-cell Lymphotrophic virus type 1 (HTLV-1) has infected more than 20 million people worldwide. Northeast of Iran, Mashhad, the capital of Razavi Khorasan Province, is endemic for HTLV-1 with a prevalence of 3% among general population.
Objective: We evaluated the ICSI outcome in our program for (HTLV-1) serodiscordant couples (SDCs) with the female infected in comparison with control group.
Materials and Methods: This study was performed between 2007 and 2011 in Novin Infertility Treatment Center (Mashhad, Iran). We examined 32 ICSI cycles of HTLV-1 infected women in comparison with an age matched control group (n=62). ICSI outcome was compared regarding fertilization rate (FR), embryo quality parameters, implantation rate (IR), clinical pregnancy rate (PR), and abortion rate (AR).
Results: Fertilization (p=0.15), implantation (p=0.33), and pregnancy rate (p=0.12) were similar between the groups. No difference was found regarding the number of transferred embryos (on day 2 or 3) and cryopreserved embryos, multiple pregnancies, or abortion rates between the groups.
Conclusion: Our results suggest that the embryo quality and ICSI outcome are not affected by HTLV-1 infection in serodiscordant couples. The major finding of this study is that the outcome of ICSI in HIV-I-infected patients and seronegative controls is similar.
Tahereh Khosrorad, Mahrokh Dolatian, Hedyeh Riazi, Zohreh Mahmoodi, Hamid Alavimajd, Soodeh Shahsavari, Mitra Bakhtiari,
Volume 13, Issue 9 (10-2015)
Abstract
Background: Infertility is a major reproductive health in gynecology. According to the world health organization, there are currently 50-80 million infertile couples in the world.
Objective: Considering the critical effects of lifestyle on reproductive health, this study aimed to compare the lifestyle of fertile and infertile couples in Kermanshah during 2013.
Materials and Methods: This research is a descriptive cross sectional study that was done on 216 fertile and infertile couples attending Infertility Center and six medical centers that were selected through the convenience sampling. Data were collected using a researcher-made questionnaire containing demographic and fertility-related information and also lifestyle items on nutrition, physical activity, perceived social support, responsibility for health, and inappropriate health behaviors. Descriptive statistics, logistic regression analysis, independent t, chi-square and Generalized Estimating equation were performed to analyze the data.
Results: Fertile and infertile women (86.1% and 73. 1% respectively, p= 0. 03) as well as fertile and infertile men were significantly different in terms of physical activity (87% and 96.3% p<0.001, respectively) and perceived social support (p<0.001). Moreover, there was a significant difference between fertile and infertile women in nutrition (p<0.001). Similar differences were observed in responsibility for health and inappropriate health behaviors between fertile and infertile men. However, all of the dimensions of lifestyle, except nutrition, were significantly different between fertile and infertile couples.
Conclusion: As lifestyle plays a crucial role in reproductive health, the inappropriate lifestyle of infertile couples has to be modified through effective measures such as awareness promotion, behavioral changes, and development of a healthy environment.
Zahra Shayan, Zahra Pourmovahed, Fatemeh Najafipour, Ali Mohammad Abdoli, Fatemeh Mohebpour, Sedighe Najafipour,
Volume 13, Issue 12 (12-2015)
Abstract
Background: Nowadays, infertility problems have become a social concern, and are associated with multiple psychological and social problems. Also, it affects the interpersonal communication between the individual, familial, and social characteristics. Since women are exposed to stressors of physical, mental, social factors, and treatment of infertility, providing a psychometric screening tool is necessary for disorders of this group. Objective: The aim of this study was to determine the factor structure of the general health questionnaire-28 to discover mental disorders in infertile women. Materials and Methods: In this study, 220 infertile women undergoing treatment of infertility were selected from the Yazd Research and Clinical Center for Infertility with convenience sampling in 2011. After completing the general health questionnaire by the project manager, validity and, reliability of the questionnaire were calculated by confirmatory factor structure and Cronbach's alpha, respectively. Results: Four factors, including anxiety and insomnia, social dysfunction, depression, and physical symptoms were extracted from the factor structure. 50.12% of the total variance was explained by four factors. The reliability coefficient of the questionnaire was obtained 0.90. Conclusion: Analysis of the factor structure and reliability of General Health Questionnaire-28 showed that it is suitable as a screening instrument for assessing general health of infertile women.
Zahra Zare, Malihe Amirian, Nahid Golmakani, Reza Mazlom, Mojtaba Laal Ahangar,
Volume 14, Issue 2 (2-2016)
Abstract
Background: Sexual problems have different effects on the life of people by influencing their interpersonal and marital relationships and satisfaction. Relationship between sexual dysfunctions and infertility can be mutual. Sexual dysfunction may cause difficulty conceiving but also attempts to conceive, may cause sexual dysfunction.
Objective: This paper compares sexual dysfunction in fertile and infertile women.
Materials and Methods: In this cross-sectional study, 110 infertile couples referring to Montasarieh Infertility Clinic and 110 fertile couples referring to five healthcare centers in Mashhad were selected by class cluster sampling method. Data collection tools included demographic questionnaire and Glombok-Rust Inventory of Sexual Satisfaction. Data were analyzed through descriptive and analytical statistical methods by SPSS.
Results: There was no significant difference in total score of sexual problems and other dimensions of sexual problems (except infrequency) in fertile 28.9 (15.5) and infertile 29.0 (15.4) women. Fertile women had more infrequency than infertile women (p=0.002).
Conclusion: There was no significant difference between fertile and infertile women in terms of sexual problems. Paying attention to sexual aspects of infertility and presence of programs for training of sexual skills seems necessary for couples.
Burak Kaplan, Hasan Acar,
Volume 14, Issue 11 (11-2016)
Abstract
We interested in a very nice article by Motovali-Bashi at al entitled as “Multiplex PCR based screening formicro/partial deletions in the AZF region of Y-chromosome in severe oligozoospermic and azoospermic infertile men inIran” (1). In this article, authors described the frequency of Y chromosome AZF microdeletions increased in subjectswith severe spermatogenic failure and partial deletions of AZFc associated with spermatogenic failure. However, infigure 2 of the paper, sY1291 and sY1201 STS-PCR products on agarose gel were presented erroneously. This mistakedoes not match with the legend of figure 2. sY1201 and sY1291 PCR product sizes are 677 bp and 527 bp, respectively.According to STS-PCR product sizes, sY1201 should be corrected on the top PCR product band on the description ofagarose gel. We would like to bring forward this mistake for your attention and for a possible correction.
Mahtab Sattari, Mehdi Ghiami Rad, Aaliye Ghasemzadeh, Zahra Mohammadoghli Reihan,
Volume 15, Issue 1 (1-2017)
Abstract
Background: Infertility is one of the major issues in society and its incidence is estimated to be almost 10-15%.. Chlamydia is an important cause of sexually transmitted diseases leading to infertility.
Objective: This study was designed to determine the frequency of anti-Chlamydia trachomatis (anti-C. trachomatis) antibodies in infertile women at Alzahra hospital, Tabriz, Iran.
Materials and Methods: In this cross-sectional study, the blood samples were collected randomly from 184 infertile women (case group) and 100 pregnant women (control group).the frequency of specific IgG and IgM anti-Chlamydia trachomatis antibodies were evaluated using ELISA.
Results: The frequency of anti-C. trachomatis IgG in pregnant and infertile women was 18% and 35.88%, respectively. The frequency of anti- C. trachomatis IgM in pregnant and infertile women was 2% and 5.44%.Our results showed the significant high rate of anti-Chlamydia trachomatis IgG (p=0.035), IgM (p=0.004) (p<0.05) in infertile women. Also, no significant relation was seen in the frequency of antibody between urban and rural women, IgG (p=0.690), IgM (p=0.486). The highest prevalence of positive cases was seen among the 21-30 years of age groups. There was not a significant relationship between age of infertile women and the amount of anti-Chlamydia trachomatis antibody, IgG (p=0.437), IgM (p=0.132). There was no significant relationship between tubal factor infertility and the frequency of anti C. trachomatis antibodies, IgG (p=0.208), IgM (p=0.082) (p>0.05).
Conclusion: According to the high frequency of antibody anti-C. trachomatis among infertile women in competition to the control group, evaluation and treatment of Chlamydia infections is necessary in these patients.
Abooei A, Afshani S,
Volume 19, Issue 5 (5-2021)
Abstract
Background: Spouses, who experience infertility, are much more overwhelmed by failure, anxiety, stress, and unpleasant marital relationships than other spouses. Infertility often has negative effects on the relationships between spouses. Infertile women are more likely to suffer from these unpleasant marital relationships.
Objective: By using a qualitative grounded theory approach, 21 women were selected and studied using theoretical sampling. Theoretical sampling continues until data saturation occurs. These qualitative interviews were conducted between January 2019 and January 2020. Data were collected and analyzed using open and axial coding.
Materials and Methods: The findings of this study included 7 main categories and one core category called Protester Caregivers. Consequently, conceptual tables, paradigm model and theoretical schema were presented. Determining the results in general indicates the phenomenon of “Protester Caregivers" in the target community.
Results: The findings of this study included 7 main categories and one core category called Protester Caregivers. Consequently, conceptual tables, paradigm model and theoretical schema were presented. Determining the results in general indicates the phenomenon of “Protester Caregivers" in the target community.
Conclusion: Based on the traditional culture of the target community, infertile women struggle with the men who play the role of "caregivers" as well as consistently protest their infertility. This paradoxical phenomenon leads to the emergence of contradictory strategies and outcomes, and make infertile women to rethink about their choices.
Jaberi Asl A, Dashti Ghr, Sharifi M,
Volume 19, Issue 5 (5-2021)
Abstract
Background: Infertility is a common complete disorder, which can be caused by oxidative stress. Accumulating evidence suggest that long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and HOX transcript antisense RNA (HOTAIR) is involved in the regulation of the oxidative stress responses.
Objective: We aimed to investigate the possible expression status of MALAT1 and HOTAIR in the sperm and its correlation between sperm parameters and malondialdehyde (MDA) levels.
Materials and Methods: Specimens were obtained randomly from 25 fertile men and 25 infertile men, aged between 25-55 yr old. Sperm parameters were evaluated by computer-aided sperm analysis. Sperm chromatin quality were assessed by acridine orange staining method. Seminal MDA levels were determined by thiobarbituric acid reaction method. The expression of MALAT1 and HOTAIR was detected by RT-PCR.
Results: A decreased level of MALAT1 and HOTAIR expression was observed to be associated with the infertile patients (p < 0.001). The relative expression level of MALAT1 and HOTAIR were positively correlated with motility and morphology (p < 0.001). Meanwhile we found the expression levels of genes were negatively correlated with sperm chromatin damage and MDA levels (p < 0.001).
Conclusion: The decreased expression of MALAT1 and HOTAIR resulted in high level of MDA, DNA denaturation and abnormal semen parameters. These findings exhibited the important implications of lncRNAs serving as a potential therapeutic indicator to assess male infertility in assisted reproductive procedures.
