en ارتباط بین IGFBP-1 و HOMA-IR در سندرم تخمدان پلی کیستیک با مقاومت به انسولین Original Article Original Article <strong><span style="font-family:b mitramso-ascii-font-family:arial;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">اتیولوژی زمینه</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ای سندرم تخمدان پلی</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">کیستیک ناشناخته است و به نظر می&shy;رسد که یک ارتباط قوی با مقاومت به انسولین داشته باشد. </span></span><span dir="LTR">HOMA-IR</span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">یک وسیله خوب در اندازه&shy; گیری مقاومت به انسولین می&shy;باشد. سطح پایین </span></span><span dir="LTR">IGFBP-1</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> در سندرم تخمدان پلی&shy; کیستیک منجر به بیان این فرضیه شد که هیپرانسولینمیا باعث مهار تولید </span></span><span dir="LTR">IGFBP-1</span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">شده که به نوبه خود باعث تحریک تولید زیاد اندروژن می&shy;شود.</span></span><strong><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف این مطالعه آنالیز ارتباط بین سطح </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">HOMA-IR</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">با مقاومت به انسولین در سندرم تخمدان پلی&shy; کیستیک می&shy;باشد.</span></span><strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"></span></span></strong><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">موارد و روش &shy;ها:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> یک مطالعه موضعی مقطعی بر روی ۱۰۵ زن با سندرم تخمدان پلی&shy;کیستیک شامل ۶۰ زن با مقاومت به انسولین انجام شد. متوسط </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">HOMA-IR</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> به ترتیب </span></span><span dir="LTR"><span style="font-size:10.0pt;">&mu;g/l</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">4/7821</span></span><span style="font-size:11.0pt;">&plusmn;</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">6/507 و 1/666</span></span><span style="font-size:11.0pt;">&plusmn;</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">3/633 بود.</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">سطح پایین </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">در تمام زن&shy;های مقاوم به انسولین وجود داشت. ارتباطی بین </span></span><span dir="LTR"><span style="font-size:10.0pt;">HOMA-IR</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و وزن بالا وجود داشت (0/045</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) در حالیکه </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> هیچ ارتباطی را با وزن بالا نشان نداد (0/106</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">). به&shy;علاوه هیچ ارتباطی بین </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و </span></span><span dir="LTR"><span style="font-size:10.0pt;">HOMA-IR</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> به&shy;عنوان نشانگر مقاومت به انسولین مشاهده نشد.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه&shy; گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">علیرغم کاهش </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> به نظر می&shy;رسد که هیچ ارتباطی بین </span></span><span dir="LTR"><span style="font-size:10.0pt;">IGFBP-1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">HOMA-IR</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">به&shy;عنوان نشانگر مقاومت به انسولین وجود ندارد.</span></span> <div><strong>Background:</strong> The underlying etiology of polycystic ovarian syndrome (PCOS) is unknown and assumed to have a strong correlation with insulin resistance. Homeostasis Model Assessment of insulin resistance (HOMA-IR) is a good tool to assess insulin resistance. Low levels of serum Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) in PCOS women led to the hypothesis that hyperinsulinemia in PCOS inhibits the production of IGFBP-1, which in turn stimulates excessive androgen production.<br> <strong>Objective:</strong> The study is aimed to analyze the correlation between the levels of IGFBP-1 and HOMA-IR on insulin resistance in PCOS.<br> <strong>Materials and Methods:</strong> A cross-sectional study among 105 PCOS women, including 60 women with insulin resistance were recruited. The mean of IGFBP-1 and HOMA-IR were 6.507&plusmn;4.7821 &mu;g/l and 3.633&plusmn;1.666 respectively.<br> <strong>Results:</strong> Low levels of IGFBP-1 were detected in all insulin resistance women. There was a correlation between HOMA-IR and overweight (p=0.045), while IGFBP-1 showed no correlation with overweight (p=0.106). In addition, no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance was detected.<br> <strong>Conclusion: </strong>Despite the decrease in IGFBP-1, it seems that there is no correlation between IGFBP-1 with HOMA-IR as a marker of insulin resistance.</div> پروتئین متصل شونده به فاکتور رشد انسولین-1 (IJFBP-1), مقاومت به انسولین, سندرم تخمدان پلی کیستیک Insulin-like growth factor binding protein 1, Insulin resistance, Polycystic ovarian syndrome. 679 682 http://ijrm.ir/browse.php?a_code=A-10-549-5&slc_lang=en&sid=1 Arini Firmansyah maisurichalid@gmail.com 0000-0002-8047-9650 No Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia. Maisuri Tadjuddin Chalid maisurichalid@gmail.com 0000-0001-8790-4915 Yes Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia. Retno Budiati Farid maisurichalid@gmail.com 0000-0001-9289-7342 No Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia. Nusratuddin Abdullah maisurichalid@gmail.com 0000-0003-2373-8430 No Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Makassar, Indonesia.