International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1397
8
1
gregorian
2018
11
1
16
11
online
1
fulltext
en
Investigation of anti-mullerian hormone (AMH) level and ovarian response in infertile women with endometriosis in IVF cycles
Short Research Reports
Short Research Reports
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> هورمون آنتی­ مولرین در زنان نابارور یک نشانه پیش­گویی ­کننده پاسخ تخمدان به تحریک در سیکل­ های </span></span><span dir="LTR"><span style="font-size:10.0pt;">IVF</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">است.</span></span><span dir="LTR"><span style="font-size:11.0pt;"></span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> مطالعه اخیر برای تعیین ارتباط بین سطح هورمون آنتی­ مولرین و نتایج درمان ناباروری در خانم­های نابارور مبتلا به اندومتریوزیز در مقایسه با غیر­اندومتریوزیز طراحی شده.</span></span><span dir="LTR"><span style="font-size:11.0pt;"></span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش ها:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> در این مطالعه مورد شاهدی، 64 خانم ناباروری که از سال 2015 تا 2017 به بیمارستان شریعتی مراجعه کرده بودند وارد مطالعه شدند. آنها به دو گروه اندومتریوزیز و غیر اندومتریوزیز تقسیم و سطح هورمون آنتی ­مولرین در همه افراد مشخص شد. نتایج درمانی ارزیابی و ارتباط بین این عوامل بررسی گردید.</span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج:</span></span></strong> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">میزان هورمون آنتی­ مولرین </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/06</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">؛ تعداد تخمک ­ها </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/7</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و جنین­ های بدست آمده </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/7</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">، میزان لانه­ گزینی </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/6</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و حاملگی کلینیکی </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/9</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بین دو گروه مشابه بودند. در بیماران با مرحله سه یا چهار اندومتریوزیز که سطح سرمی هورمون آنتی­ مولرین پایین­ تری داشتند </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/001</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">به طور مشخصی تخمک </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/001</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و جنین­ های قابل انتقال </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/03</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">کمتری بدست آمد. به هرحال میزان حاملگی و لانه­ گزینی در دو گروه فرقی نداشت (به ترتیب 0/6</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و 0/7</span></span><span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه</span></span></strong> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">به ­طور کلی بر اساس نتایج بدست آمده، ذخیره تخمدانی نسبت به پذیرش اندومتر نقش مشخص­تری در پیشگویی نتایج درمان ناباروری دارد.</span></span>
<div><strong>Background</strong>: Endometriosis, can cause ovarian conflict and reduced ovarian reserve that could lead to lower response to assisted reproductive techniques<br>
<strong>Objective:</strong> Current study was conducted to determine the association between level of anti-mullerian hormone (AMH) and the infertility treatment outcomes in infertile females with endometriosis versus the non-endometriosis infertile subject.<br>
<strong>Materials and Methods:</strong> In this case-control study, 64 infertile females who referred to Shariati Hospital from April 2015 to November 2017 were enrolled. They were divided in two groups of 32 patients (endometriosis and non-endometriosis women). The anti-mullerian hormone level among all subjects was determined, treatment outcomes were evaluated and association between these factors was assessed.<br>
<strong>Results:</strong> It was seen that the anti-mullerian hormone (p=0.06), the number of retrieved oocytes (p=0.7) and embryos (p=0.7), implantation rate (p=0.6) and clinical pregnancy rate (p=0.9) were similar between two groups. In patients with stage 3 or 4 endometriosis who had lower serum AMH level significantly (p=0.001) less oocytes were retrieved (p=0.001) and less transferrable embryos (p=0.03) were achieved. However, implantation and pregnancy rates did not differ (p=0.7) (p=0.6).<br>
<strong>Conclusion: </strong>Totally, according to the obtained results, it may be concluded that ovarian reserve has more significant role in predicting infertility treatment outcome rather than receptive endometrium.</div>
اندومتریوزیز, تحریک تخمک گذاری, هورمون آنتی مولرین.
Endometriosis, Infertility, Anti-mullerian hormone
719
722
http://ijrm.ir/browse.php?a_code=A-10-549-11&slc_lang=en&sid=1
Leili
Safdarian
لیلی
صفدریان
hoseinimosa@sina.tums