en Letter to Editor Letter to Editor As clinical investigators and researchers exploring the role of insulin receptor gene (INSR) in polycystic ovary syndrome (PCOS), we wish to express our  concern about the study by Tehrani et al. (1) that aimed to explore the correlation between INSR and adiponectin genes and PCOS. We are afraid that it might have technical flaws and take confusion and concerns to the readership. polycystic ovary syndrome (PCOS), readership, polymorphism analysis (PCR-RFLP) 217 222 http://ijrm.ir/browse.php?a_code=A-10-549-297&slc_lang=en&sid=1 Chun Feng doctovfc@zju.edu.cn No Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, China Ping-ping Lv Yes Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, Zhejiang, 310058, China Min Jin No The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China Jin-Ming Shen No The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310018, China Tian-he Huang No The First Affiliated Hospital, College of Medicine of Xi’an Jiaotong University, Xi’an, Shanxi, 710061, China