en اثر فصل بر نتایج باروری در بیماران تحت تزریق درون سیتوپلاسمی اسپرم: یک مطالعه توصیفی مقطعی Reproductive Biology Original Article Original Article <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">شواهد متناقضی در ارتباط با اثر فصل روی نتایج کسب شده از روش&shy;های کمک باروری وجود دارد.</span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">هدف از مطالعه حاضر، مقایسه گذشته</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نگر نتایج باروری در بین چهار فصل سال در طول سه سال، در بیماران تحت اولین سیکل تزریق درون سیتوپلاسمی اسپرم (</span></span><span dir="LTR"><span style="font-size:10.0pt;">ICSI</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) بود.</span></span><strong><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مواد و روش&shy; ها: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">در مطالعه توصیفی مقطعی حاضر، تعداد 3670 بیمار که تحت اولین سیکل </span></span><span dir="LTR"><span style="font-size:10.0pt;">ICSI</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">خود قرار گرفتند، وارد شدند. بر اساس زمان کسب اووسیت، بیماران به 4 گروه تقسیم شده و نتایج مورد مقایسه قرار گرفت: بهار (808 نفر)، تابستان (994 نفر)، پاییز (1066 نفر) و زمستان (802 نفر). صفات پایه و مربوط به تحریک تخمدان در بین گروه&shy;ها مورد مقایسه قرار گرفت.</span></span><strong><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">تعداد و تحرک اسپرم به صورت معناداری در طول تابستان کم</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">تر بود در حالی که تعداد کل اووسیت</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">های کسب شده و متافاز 2 به صورت معناداری در فصل تابستان بیشتر بود. نرخ لقاح به صورت معناداری در فصل پاییز بیشتر بود. تعداد جنین</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">های انتقال داده شده به صورت معناداری در طول زمستان و تابستان بیشتر بود. الگوی مشابهی در میزان لانه</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">گزینی و حاملگی در بین چهار گروه مشاهده شد.</span></span><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نتیجه &shy;گیری: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">علی</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">رغم آنکه روش </span></span><span dir="LTR"><span style="font-size:10.0pt;">ICSI</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">، اثر فصل بر نتایج حاملگی را کاهش می</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">دهد، تغییرات نرخ حاملگی در بین فصول مختلف، بدون الگوی مشخص رخ می</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">دهد. به نظر می</span></span><span style="font-size:11.0pt;">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">رسد که انجام مراحل روش&shy;های کمک باروری در فصول خاص باید به عنوان یک فاکتور موثر مورد توجه قرار گیرد.</span></span><strong><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> &nbsp;<br> <strong><em><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:10.0pt;"></span></span></span></em></strong> <strong>Background:</strong> There is conflicting evidence regarding the impact of season on the assisted reproductive technology outcome.<br> <strong>Objective:</strong> To retrospectively compare three-year outcome of women undergoing their first intracytoplasmic sperm injection cycle, across seasons.<br> <strong>Materials and Methods:</strong> In this descriptive cross-sectional study, 3,670 women who underwent their first intracytoplasmic sperm injection cycle in Mehr Medical Institute, Rasht, Iran between April 2010 and May 2014 were studied. Women were divided into four groups according to the day of oocyte retrival as: spring (n = 808), summer (n = 994), autumn (n = 1066), and winter (n = 802). Basal and stimulation charecteristics were compared among groups.<br> <strong>Results:</strong> While sperm concentration and motility were significantly lower during summer, the total number of retrieved and metaphase II oocytes were significantly higher (p = 0.0001, p = 0.0001, p = 0.004, p = 0.02, respectively). Fertilization rate were significantly higher during autumn (p = 0.0001). Also, the number of high- quality transferred embryos were significantly higher during summer and winter (p = 0.03). A similar pattern was observed in implantation rate and pregnancy over the four seasons <span dir="RTL"></span><br> <strong>Conclusion:</strong> Despite the fact that intracytoplasmic sperm injection minimize the seasonal effect on pregnancy outcome, changes in pregnancy rate still occur among different seasons without particular pattern. It seems that performing assisted reproductive technology procedures in a particular season should be considered as an effective factor. تزریق درون سیتوپلاسمی اسپرم, فصل, نتایج حاملگی. Intracytoplasmic sperm injection, Seasons, Pregnancy outcome. 989 994 http://ijrm.ir/browse.php?a_code=A-10-1074-1&slc_lang=en&sid=1 Marzieh Mehrafza marzieh.mehrafza@gmail.com 0000-0002-0476-6535 No Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran. Maryam Asgharnia drmaryamasgharnia@gmail.com 0000-0002-6950-7542 Yes Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran. Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Azadeh Raoufi az.raoufi@gmail.com 0000-0002-6005-1999 No Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran Elmira Hosseinzadeh elmira.hosseinzadeh@yahoo.com 0000-0002-5895-4937 No Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran Sajedeh Samadnia s.samadnia@gmail.com 0000-0002-8981-3061 No Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran Zahra Atrkar Roushan atrkarroushan@gmail.com 0000-0001-8687-1242 No Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.