en کلوئید مصنوعی در مقایسه با آلبومین انسانی برای درمان سندرم تحریک شدن بیش از حد تخمدان: یک مطالعه کوهورت گذشته نگر Original Article Original Article <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">محلول کلوئید اپتیمال برای درمان سندرم تحریک شدن بیش از حد تخمدان (</span></span><span dir="LTR"><span style="font-size:10.0pt;">OHSS</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) هنوز مشخص نشده است.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف ما مقایسه کلوئید مصنوعی (</span></span><span dir="LTR"><span style="font-size:10.0pt;">Ac</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) با آلبومین انسانی (</span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) برای درمان </span></span><span dir="LTR"><span style="font-size:10.0pt;">OHSS</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">می</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">باشد.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش &shy;ها:</span></span></strong> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">در این مطالعه کوهرت گذشته</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نگر، اطلاعات بیماران مبتلا به </span></span><span dir="LTR"><span style="font-size:10.0pt;">OHSS</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">از یک بانک اطلاعاتی ملی بیماران در ژاپن جمع</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">آوری شد. بیماران مایع داخل وریدی </span></span><span dir="LTR"><span style="font-size:10.0pt;">AC</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">(156 نفر) یا </span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">(127 نفر) دریافت کردند. دو گروه از نظر مدت ماندگاری، بروز عوارض بعد درمان و جراحی نهایی مقایسه شدند.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">در آنالیز رگرسیون خطی مولتی واریانس برای مدت زمان ماندگاری </span></span><span dir="LTR"><span style="font-size:10.0pt;">log-transformed</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">با رفرنس به بیماران مبتلا به </span></span><span dir="LTR"><span style="font-size:10.0pt;">OHSS</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">دریافت کننده </span></span><span dir="LTR"><span style="font-size:10.0pt;">AC</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">رگرسیون </span></span><span dir="LTR"><span style="font-size:10.0pt;">coefficient</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">(95% </span></span><span dir="LTR"><span style="font-size:10.0pt;">confidence interval</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) در بیماران دریافت کننده </span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">به میزان 03/0 بود (42/0 </span></span>&nbsp;<span dir="LTR"><span style="font-size:10.0pt;">p=</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">،09/0-04/0-). ترومبوآمبولی در 2 نفر از گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و 3 نفر از گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">AC</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">مشاهده شد. 2 نفر از گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">مبتلا به نارسایی کلیه در بیمارستان بستری شدند. هیچ کدام از بیماران در دو گروه تحت جراحی نهایی قرار نگرفتند.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه&shy; گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج حاصل نشان&shy;دهنده کارآیی قابل مقایسه بین </span></span><span dir="LTR"><span style="font-size:10.0pt;">AC</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و </span></span><span dir="LTR"><span style="font-size:10.0pt;">HA</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">برای درمان </span></span><span dir="LTR"><span style="font-size:10.0pt;">OHSS</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">بود. هیچ تفاوت معنی</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">داری در عوارض بعد درمان بین دو گروه مشاهده نشد.</span></span><br> &nbsp; <strong>Abstract</strong><br> <strong>Background:</strong> The optimal colloid solution for the treatment of ovarian hyperstimulation syndrome (OHSS) remains to be established.<br> <strong>Objective: </strong>We aimed to compare artificial colloids (AC) with human albumin (HA) for the treatment of OHSS.<br> <strong>Materials and Methods: </strong>In this retrospective cohort study, data for OHSS participants were collected from a national inpatient database in Japan. The participants received intravenous fluid management with AC (n = 156) or HA (n = 127). We compared the two groups in terms of the length of stay, development of post-treatment complications, and termination surgery.<br> <strong>Results: </strong>In multivariable linear regression analyses for log-transformed length of stay with reference to the OHSS participants receiving AC, the regression coefficient (95% confidence interval) in participants receiving HA was 0.03 (-0.04-0.09, p = 0.42). Thromboembolism occurred in two participants in the HA group and three participants in the AC group. Two participants in the HA group suffered renal failure during hospitalization. No participants underwent termination surgery in the two groups.<br> <strong>Conclusions: </strong>The present results showed comparable efficacy between AC and HA for the treatment of OHSS. There were no significant differences in post-treatment complications between the two groups. سندرم تحریک شدن بیش از حد تخمدان, درمان, کلوئید, مدت اقامت Ovarian hyperstimulation syndrome, Treatment, Colloid, Length of stay 709 716 http://ijrm.ir/browse.php?a_code=A-10-1-666&slc_lang=en&sid=1 Tetsuji Minami tetsujiminami-tky@umin.ac.jp 0000-0003-4418-0237 Yes Center for Reproductive Medicine, Dokkyo Medical University Saitama Medical Center, Saitama, Japan, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, Japan. Hayato Yamana 0000-0003-2214-6695 No Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Daisuke Shigemi 0000-0002-3483-6047 No Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan Hiroki Matsui 0000-0002-9605-442X No Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan Kiyohide Fushimi 0000-0002-1894-0290 No Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan Hideo Yasunaga1 0000-0002-6017-469X No Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.