en بررسی رابطه مصرف قرص های ضد بارداری با دوز کم با برخی عوامل خطر بیماری های قلبی-عروقی در میان زنان 15 تا 35: یک مطالعه کوهورت ترکیبی Original Article Original Article <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">بیماری&shy;های قلبی عروقی قابل پیشگیری هستند، بنابراین شناخت عوامل خطر این بیماری&shy;ها برای ارائه&shy;دهندگان خدمات بهداشتی بسیار ضروری می&shy;باشد</span></span><strong><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف اصلی این تحقیق، دستیابی به یک بینش عمیق&shy;تر درباره تأثیر استفاده طولانی مدت از قرص&shy;های ضد&shy;بارداری خوراکی با دوز کم (</span></span><span dir="LTR"><span style="font-size:10.0pt;">OCP</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) در مورد عوامل خطر بیماری&shy;های قلبی عروقی است.</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش &shy;ها:</span></span></strong><span style="font-family:b mitra;"> ا</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ین پژوهش یک مطالعه کوهورت ترکیبی (تاریخی و آینده&shy;نگر) است که بر روی 100 زن دارای چرخه قاعدگی طبیعی در سنین 15 تا 35 سال انجام شده است که به مراکز بهداشتی و درمانی یزد مراجعه کرده&shy;اند. شرکت&shy;کنندگان در دو گروه قرار گرفتند: گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">OCP</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">برای 0-3 ، 4-23 و 24-36 ماه و گروه غیر </span></span><span dir="LTR"><span style="font-size:10.0pt;">OCP</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">قرص</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ها را مصرف می</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">کرد. شرکت</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">کنندگان برای حداقل 3 ماه و حداکثر شش ماه پیگیری شدند.</span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">بالاترین سطح لیپوپروتئین با چگالی کم (</span></span><span dir="LTR"><span style="font-size:10.0pt;">LDL</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)، هموسیستئین، کلسترول، تری&shy;گلیسیرید و فشار خون سیستولیک در گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">OCP</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">در مدت زمان 24 تا 36 ماه مشاهده شد. آزمایش توکی نشان داد که اختلاف معنی</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">داری در</span></span><span dir="LTR"><span style="font-size:10.0pt;">LDL </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">&nbsp;(01/0 </span></span><span style="font-size:10.0pt;">=</span><span dir="LTR"><span style="font-size:10.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)، کلسترول (01/0 </span></span><span style="font-size:10.0pt;">=</span><span dir="LTR"><span style="font-size:10.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)، تری&shy;گلیسیرید (001/0 </span></span><span style="font-size:10.0pt;">></span><span dir="LTR"><span style="font-size:10.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) و میزان هموسیستئین (001/0 </span></span><span style="font-size:10.0pt;">></span><span dir="LTR"><span style="font-size:10.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)، فشار خون سیستولیک (04/0 </span></span><span style="font-size:10.0pt;">=</span><span dir="LTR"><span style="font-size:10.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) وجود دارد. </span></span><br> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه&shy; گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج مطالعه نشان می&shy;دهد که مصرف طولانی مدت </span></span><span dir="LTR"><span style="font-size:10.0pt;">OCP</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">با دوز پایین می</span></span><span dir="LTR"><span style="font-family:arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">تواند در بروز برخی از عوامل خطر (فشار خون سیستولیک، سطح هموسیستئین، کلسترول، </span></span><span dir="LTR"><span style="font-size:10.0pt;">LDL-c</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و تری&shy;گلیسیرید) افزایش یافته و منجر به بروز بیماری&shy;های قلبی عروقی در بین زنان سالم شود.</span></span><span style="font-family:b mitra;"><span style="font-size:10.0pt;"></span></span> <strong>Background: </strong>Cardiovascular diseases could be preventable; as a result, understanding the risk factors was regarded as the major priority for healthcare providers.<br> <strong>Objective: </strong>The main objective of this research was to achieve a deeper insight into the effect of long-term use of low-dose oral contraceptive pills (OCP) on the risk factors of cardiovascular diseases.<br> <strong>Materials and Methods</strong>: This research was a retrospective cohort conducted (historical and prospectively) conducted on 100 women with normal menstrual cycles aged 15 to 35 yr, who were referred to the healthcare centers in Yazd, Iran. The participants were categorized into two groups: The OCP group was consuming the pills for 0-3, 4-23, and 24-36 months, and the non-OCP group. Participants were followed up for a minimum of 3 months and a maximum of six months<br> <strong>Results: </strong>The highest level of low-density lipoprotein (LDL), homocysteine, cholesterol, triglyceride levels, and systolic blood pressure was observed in the OCP group in the duration of 24 to 36 months. The Tukey&rsquo;s test demonstrated that there were comprehensible differences in the LDL (p = 0.01), cholesterol (p = 0.01), triglyceride (p < 0.001), and homocysteine levels (p < 0.001), also systolic blood pressure (p = 0.04).<br> <strong>Conclusion: </strong>It was realized that the long-term consumption of low-dose OCP can augment the incidence of some risk factors (systolic blood pressure, homocysteine levels, cholesterol, LDL-c, and triglyceride) and lead to developing cardiovascular diseases amongst the healthy women. قرص های ضد بارداری خوراکی, هموسیستئین, اکسید نیتریک, نمایه چربی, بیماری های عروق کرونر Birth control pills, Homocysteine, Nitric oxide, Dyslipidemias, Coronary artery diseases 841 850 http://ijrm.ir/browse.php?a_code=A-10-1-680&slc_lang=en&sid=1 Zahra Momeni zmomeni547@gmail.com 0000-0001-6686-6139 Yes Deputy of Health, Bushehr University of Medical Sciences, Bushehr, Iran., Department of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Ali Dehghani 0000-0002-1338-3456 No Department of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Hossein Fallahzadeh 0000-0001-6518-366X No Department of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Moslem Koohgardi 0000-0001-9955-6567 No Department of Health Education and Health Promotion, Faculty of Health, Rafsanjan University of Medical Sciences and Health Services, Kerman, Iran. Maryam Dafei 0000-0001-9509-6719 No Department of Midwifery, School of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Masoud Mohammadi 0000-0002-5722-8300 No Department of Nursing, Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.