en التهاب مزمن در سندرم تخمدان پلی‌کیستیک: یک مطالعه مورد شاهدی با استفاده از چندین نشانگر Reproductive Pattology Original Article Original Article <div style="text-align: justify;"><strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">سندرم تخمدان پلی&shy;کیستیک (</span></span><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) با مقاومت به انسولین و افزایش خطر بیماری</span></span><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;">&shy;</span></span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">های قلبی عروقی و دیابت همراه است. در چندین مطالعه التهاب مزمن در </span></span><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مشاهده شده است، اما مطالعاتی نیز با شواهد مخالف گزارش شده همچنین در مورد هندی&shy;ها نیز تحقیق کافی در این زمینه وجود ندارد.</span></span><strong><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">ارزیابی التهاب مزمن در </span></span><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">و یافتن ارتباط آن با پارامترهای تن سنجی و بیوشیمیایی مناسب.</span></span><strong><span dir="LTR"><span style="font-family:Arial,sans-serif;"><span style="font-size:11.0pt;"></span></span></span></strong><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مواد و روش &shy;ها: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">التهاب مزمن در 30 زن مبتلا به </span></span><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">(گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">A</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) و 30 شاهد سالم (گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">B</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) به وسیله پروتئین واکنش پذیر </span></span><span dir="LTR"><span style="font-size:10.0pt;">C</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;"> بسیار حساس (</span></span><span dir="LTR"><span style="font-size:10.0pt;">hsCRP</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">)، اینترلوکین 6 (</span></span><span dir="LTR"><span style="font-size:10.0pt;">IL-6</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">)، فاکتور نکروز تومور آلفا (</span></span><span dir="LTR"><span style="font-size:10.0pt;">TNF&alpha;</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) و ریز ذرات پلاکت (</span></span><span dir="LTR"><span style="font-size:10.0pt;">PMP</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) سنجیده شد. در گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">A</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">، رابطه التهاب مزمن با مقاومت به انسولین، تستوسترون سرم، نسبت دور کمر به باسن (</span></span><span dir="LTR"><span style="font-size:10.0pt;">WHR</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) و ترانس آمیناز پیروات گلوتامات سرم (</span></span><span dir="LTR"><span style="font-size:10.0pt;">SGPT</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">) بررسی شد.</span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">در گروه</span></span><span dir="LTR"><span style="font-size:10.0pt;">A</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">،</span></span><span dir="LTR"><span style="font-size:10.0pt;">hsCRP</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">، </span></span><span dir="LTR"><span style="font-size:10.0pt;">TNF&alpha;</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">و </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMP</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">در مقایسه با گروه </span></span><span dir="LTR"><span style="font-size:10.0pt;">B</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;"> به طور قابل توجهی افزایش یافته بود، با این حال، سطح </span></span><span dir="LTR"><span style="font-size:10.0pt;">IL-6</span></span><span style="font-family:B Mitra;"><span style="font-size:11.0pt;"> بین گروه&shy;ها مشابه بود. در گروه</span></span><span dir="LTR"><span style="font-size:10.0pt;">A</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">، </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMP</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">ارتباط مثبت و معناداری با نسبت دور کمر به باسن و تستوسترون سرم نشان داد. </span></span><span dir="LTR"><span style="font-size:10.0pt;">IL-6</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">همبستگی مثبت و معناداری با حساسیت به انسولین و همبستگی منفی معنی&shy;داری با مقاومت به انسولین و گلوتامات پیرووات ترانس آمیناز سرم را نشان داد.</span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:11.0pt;">نتیجه&shy; گیری: </span></span></strong><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">با التهاب مزمن در ارتباط است و </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMP</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">با چاقی</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">مرکزی و هایپر آندروژنیسم بیوشیمیایی در زنان مبتلا به </span></span><span dir="LTR"><span style="font-size:10.0pt;">PCOS</span></span> <span style="font-family:B Mitra;"><span style="font-size:11.0pt;">ارتباط مثبت دارد.</span></span><br> &nbsp;</div> <div style="text-align: justify;"><strong>Background:</strong> Polycystic ovary syndrome (PCOS) is associated with insulin resistance and elevated risk of cardiovascular disease and diabetes. Chronic inflammation has been observed in PCOS in several studies but there is also opposing evidence and a dearth of research in Indians.<br> <strong>Objective:</strong> To estimate chronic inflammation in PCOS and find its relationship with appropriate anthropometric and biochemical parameters.<br> <strong>Materials and Methods:</strong> Chronic inflammation was assessed in 30 women with PCOS (Group A) and 30 healthy controls (Group B) with highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF&alpha;), and platelet microparticles (PMP). In group A, the relationship of chronic inflammation with insulin resistance, waist hip ratio (WHR) serum testosterone, and serum glutamate pyruvate transaminase (SGPT) were examined.<br> <strong>Results:</strong> In group A, the hsCRP, TNF&alpha;, and PMP were significantly elevated compared to group B. However, IL-6 level was similar between the groups. In Group A, PMP showed a significant positive correlation with waist-hip ratio and serum testosterone. IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase.<br> <strong>Conclusions:</strong> PCOS is associated with chronic inflammation and PMP correlates positively with central adiposity and biochemical hyperandrogenism in women with PCOS.<br> &nbsp;</div> سندرم تخمدان پلی­کیستیک, التهاب, پروتئین واکنش پذیر C, اینترلوکین 6, فاکتور نکروز تومور, ریز ذرات. Polycystic ovary syndrome, Inflammation, C-reactive protein, Interleukin-6, Tumor necrosis factor, Microparticles 313 320 http://ijrm.ir/browse.php?a_code=A-10-1372-1&slc_lang=en&sid=1 Soumik Goswami dr.soumikgoswami@gmail.com 0000-0002-4057-3554 Yes Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Subhadip Choudhuri subhadip1022@yahoo.com 0000-0002-0119-1844 No Department of Biochemistry, Institute of Postgraduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Basudev Bhattacharya bbasudev@rediffmail.com 0000-0002-3165-4563 No Department of Biochemistry, Institute of Postgraduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Rana Bhattacharjee dr.r.bhatta@gmail.com 0000-0002-0362-5036 No Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Ajitesh Roy ajiteshmd@yahoo.com 0000-0002-8864-8703 No Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Satinath Mukhopadhyay satinath.mukhopadhyay@gmail.com 0000-0001-8033-5748 No Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Sujoy Ghosh drsujoyghosh2000@gmail.com 0000-0002-7343-8594 No Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India. Subhankar Chowdhury subhankar.chowdhury@gmail.com 0000-0002-5853-5249 No Department of Endocrinology and Metabolism, Institute of Post Graduate Medical Education & Research and Seth Sukhlal Karnani Memorial Hospital, Kolkata, West Bengal, India.