International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1400
11
1
gregorian
2022
2
1
20
2
online
1
fulltext
en
بررسی رابطه بین هایپوگلایسمی بعد تولد با نتیجه سونوگرافی داپلر شریان نافی در نوزادان دچار محدودیت رشد داخل رحمی در سه ماهه سوم حاملگی: یک مطالعه طولی
The relationship between postnatal hypoglycemia and umbilical artery Doppler ultrasonography in neonates with intrauterine growth restriction: A longitudinal follow-up study
Reproductive Endocrinology
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">محدودیت رشد داخل رحمی (</span></span><span dir="LTR" style="font-size:10.0pt">IUGR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)</span></span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">به جنین­هایی اطلاق می­شود که براساس تعریف وزن تخمینی سونوگرافی آنها کمتر از صدک 10</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"Sakkal Majalla"">٪</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> باشد. هایپوگلایسمی یک نگرانی بزرگ در نوزادان با محدودیت رشد می­باشد</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif"">.</span></span> <span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">بررسی رابطه بین های‍‍پوگلایسمی بعد تولد با نتیجه سونوگرافی داپلر شریان نافی در نوزادان دچار محدودیت رشد داخل رحمی.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش ­ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این<b> </b>مطالعه طولی شامل 114 نوزاد با تشخیص محدودیت رشد داخل رحمی</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"Sakkal Majalla"">٬</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> با سن حاملگی 28 تا40 هفته در بازه زمانی اردیبهشت 1395 تا مهر ماه 1396 در بیمارستان شهید صدوقی یزد می­باشد، که برحسب نوع سونوگرافی داپلر در سه زیر گروه داپلر نرمال</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"Sakkal Majalla"">٬</span></span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">فقدان داپلر و داپلر معکوس قرار می­گیرند</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif"">.</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> قند خون نوزادان طی ساعات 1، 2، 3، 6، 12، 24 و 48 ساعت بعد از تولد گرفته شده و با توجه به گایدلاین در گروه هایپوگلایسمی یا یوگلایسمی قرار گرفتند.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">از تعداد 114 نمونه وارد شده به مطالعه تعداد 75 مورد (8/65%) دارای سونوگرافی داپلر شریان نافی نرمال، تعداد 29 مورد (4/25%) دارای سونوگرافی داپلر شریان نافی فقدان دیاستول و تعداد 10 مورد دارای سونوگرافی داپلر شریان نافی معکوس بودند. بین میانگین قند خون ساعت اول در 3 گروه سونوگرافی داپلر شریان نافی اختلاف معنی­داری وجود داشت (001/0</span></span><span dir="LTR" style="font-size:10.0pt">< </span> <span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">).</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هایپو گلایسمی بعد از تولد در نوزادان </span></span> <span dir="LTR" style="font-size:10.0pt">IUGR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">با نتیجه سونوگرافی داپلر شریان نافی در دوران حاملگی مرتبط می­باشد.</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Abstract</span></span></b></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Intrauterine growth restriction (IUGR) refers to fetuses with an estimated ultrasonography weight below the 10% percentile. Hypoglycemia is a major concern in neonates with IUGR.<span style="background:yellow"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> To investigate the relationship between umbilical artery <span style="background:white">(UA)</span> Doppler ultrasonography and neonate hypoglycemia and IUGR.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This was a longitudinal follow-up study consisting of 114 neonates (gestational age of 28-40 wk) born with IUGR in the third trimester of pregnancy at Shahid Sadoughi Hospital, Yazd, <span style="background:white">Iran between </span>May 2016 and October 2017. The neonates were assigned into three subgroups of <span style="background:white">normal UA Doppler</span>, absent end-diastolic flow <span style="background:white">(EDF)</span> in UA Doppler, and reverse <span style="background:white">EDF </span>in UA Doppler. The blood glucose of the neonates was checked one, two, three, six, 12, 24 and 48 hr after birth, and the neonates were placed in the hypoglycemia or euglycemia groups according to guidelines. </span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Out of the 114 neonates included in the study, 75 (65.8%) had normal UA Doppler, 29 (25.4%) <span style="background:white">had absent EDF in UA Doppler, and 10 (8.8%) had reverse EDF in UA Doppler.</span> There was a significant difference in the mean blood glucose in the first hr between the normal UA Doppler group and the reverse EDF in UA Doppler group (p < 0.01).</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Postnatal hypoglycemia in neonates with IUGR is associated with the result of UA Doppler ultrasonography during pregnancy.</span></span></span></span></span></span></span></div>
محدودیت رشد, هایپوگلایسمی, سونوگرافی داپلر, شریان ناف.
Growth restriction, Hypoglycemia, Ultrasonography Doppler, Umbilical artery
137
144
http://ijrm.ir/browse.php?a_code=A-10-1511-1&slc_lang=en&sid=1
Razieh Sadat
Tabatabaie
dr.r.tabatabaee@gmail.com