en اثر نیفدیپین قبل از انتقال جنین در چرخه فناوری‌های کمک باروری: یک کارآزمایی بالینی تصادفی شده Assisted Reproductive Technologies Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">توانایی پذیرش آندومتر یک عامل حیاتی در لانه&shy;گزینی است و انقباضات بیش از حد رحمی می&shy;تواند در کاهش شانس باروری مؤثر باشد. نیفدیپین که یک مسدودکننده کانال کلسیم است می&shy;تواند این انقباضات را کاهش داده و در نتیجه بارداری را بهبود ببخشد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف از این مطالعه بررسی تأثیر نیفدیپین قبل از انتقال جنین بر میزان موفقیت بارداری زنان تحت لقاح خارج رحمی در یک مرکز ارجاعی در ایران بود.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">150 زن کاندید لقاح خارج رحمی به صورت تصادفی به دو گروه تقسیم شدند: گروه اول 30 دقیقه قبل از انتقال جنین، </span></span><span dir="LTR" style="font-size:10.0pt">mg</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">20 نیفیدیپین دریافت کردند، در حالی&shy;که گروه دوم هیچ مداخل&shy;های دریافت نکردند. فشار خون شرکت&shy;کنندگان هر 10 دقیقه برای مدت 1 ساعت زیر نظر یک متخصص بیهوشی بررسی گردید. نهایتا داده&shy;های مربوط به نرخ لانه&shy;گزینی و میزان بارداری شیمیایی و بالینی بین دو گروه مقایسه گردید.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در پایان 140 شرکت&shy;کننده تحت آنالیز نهایی قرار گرفتند. تفاوت معناداری در میزان حاملگی بالینی بین دو گروه مشاهده نشد (20% در برابر 22%، 51/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">).</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه &shy;گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تزریق نیفدیپین قبل از انتقال جنین، نرخ لانه&shy;گزینی و میزان بارداری بالینی را در زنان تحت لقاح خارج رحمی بهبود نمی&shy;بخشد.</span></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:black"><b><span lang="FR" style="font-size:12.0pt"><span new="" roman="" times="">Abstract</span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:black"><b><span lang="FR" style="font-size:12.0pt"><span new="" roman="" times="">Background:</span></span></b><span lang="FR" style="font-size:12.0pt"><span new="" roman="" times=""> Endometrial receptivity</span></span><span style="font-size:12.0pt"><span new="" roman="" times=""> is crucial for embryo implantation, and excessive uterine contraction reduces success. Nifedipine which is a calcium channel blocker, could decrease uterine contraction and improve pregnancy outcomes. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:black"><b><span style="font-size:12.0pt"><span new="" roman="" times="">Objective:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" times=""> This study aimed to assess the effect of Nifedipine before embryo transfer on the pregnancy outcome in women undergoing in vitro fertilization (IVF) in a tertiary center in Iran.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:black"><b><span lang="FR" style="font-size:12.0pt"><span new="" roman="" times="">Materials and Methods</span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" times="">:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" times=""> 150 women who were candidates for IVF were randomly assigned into 2 groups: group 1 received 20 mg Nifedipine 30 min before embryo transfer, and group 2 received no intervention. Blood pressure of the participants was monitored every 10 min for 1 hr under the supervision of an anesthesiologist.</span></span> <span style="font-size:12.0pt"><span new="" roman="" times="">Finally, implantation rate and chemical and clinical pregnancy rates were compared between groups.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:black"><b><span style="font-size:12.0pt"><span new="" roman="" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" times=""> At the end of the study, 140 participants were included in the final analyses. No significant difference was observed in clinical pregnancy rates between groups (20% vs. 22%, p = 0.51)</span></span><span lang="FR" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" times=""> Nifedipine administration before embryo transfer does not improve the implantation and clinical pregnancy rates in women undergoing IVF.</span></span></span></span></div> نیفدیپین, لقاح خارج رحمی, رحم, انقباض. Nifedipine, In vitro fertilization, Uterus, Contraction. 1013 1018 http://ijrm.ir/browse.php?a_code=A-10-1795-1&slc_lang=en&sid=1 Masoomeh Nataj Majd m-nataj@farabi.tums.ac.ir 0000-0002-0253-6090 No Department of Anesthesiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ashraf Moini Ashraf.moieni@gmail.com 0000-0002-5074-2286 No Department of Obstetrics and Gynecology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Saghar Samimi Sadeh sagharsamimi@yahoo.com 0000-0001-8359-4411 No Department of Anesthesiology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ehsan Bastanhagh e-bastanhagh@sina.tums.ac.ir 0000-0002-5323-5204 Yes Department of Anesthesiology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.