en خطر سرطان های آندومتر، تخمدان و پستان در زنان مبتلا به سندرم تخمدان پلی کیستیک: یک مرور سیستماتیک و متاآنالیز Reproductive Endocrinology Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">اگرچه مطالعات متعددی خطر ابتلا به سرطان&shy;های زنان را در بیماران مبتلا به سندرم تخمدان پلی&shy;کیستیک (</span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) ارزیابی نموده&shy;اند، لیکن همچنان در مورد خطر ابتلا به این سرطان&shy;ها اختلاف نظر وجود دارد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه با هدف بررسی ارتباط </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> با سرطان&shy;های آندومتر، تخمدان و پستان انجام شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy;ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">پایگاه‌های اطلاعاتی </span></span><span dir="LTR" style="font-size:10.0pt">PubMed</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt">Scopus</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt">Web of Science</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و </span></span><span dir="LTR" style="font-size:10.0pt">Google Scholar</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بر اساس اصطلاحات </span></span><span dir="LTR" style="font-size:10.0pt">MESH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> با استفاده از ترکیب کلمات کلیدی مناسب برای بازیابی مطالعات مشاهده‌ای در مورد سرطان‌های آندومتر، تخمدان و پستان در زنان</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، که از ابتدا تا آوریل 2020 منتشر شده بودند، جستجو شدند. این متاآنالیز برای تعیین نسبت شانس تجمعی (</span></span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) این سرطان</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">ها در بیماران </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> انجام شد. سوگیری انتشار با استفاده از آزمون بگ ارزیابی شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">از 1347 مقاله بازیابی شده از طریق جستجو در پایگاه‌های اطلاعاتی، در مجموع 14 مقاله برای این مطالعه بررسی شدند. به</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">طور&shy;کلی، نسبت شانس تجمعی پیامد مرکب شامل سرطان&shy;های پاندومتر، تخمدان و پستان در زنان مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بیشتر از زنان غیر </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بود (نسبت شانس تجمعی: 4/1؛ فاصله 95% اطمینان: 9/1</span></span><span lang="FA" style="font-size:11.0pt"><span majalla="" sakkal="" style="font-family:">-</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">1). نسبت شانس تجمعی سرطان آندومتر (نسبت شانس تجمعی: 2/2؛ فاصله 95% اطمینان: 7/4</span></span><span lang="FA" style="font-size:11.0pt"><span majalla="" sakkal="" style="font-family:">-</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">03/1) و تخمدان (نسبت شانس تجمعی: 3/1؛ فاصله 95% اطمینان: 8/1</span></span><span lang="FA" style="font-size:11.0pt"><span majalla="" sakkal="" style="font-family:">-</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">1)در در زنان مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بالاتر از گروه کنترل بود، در حالی که نسبت شانس ابتلا به سرطان پستان به طور معنی</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">داری بالاتر از گروه کنترل نبود.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy;گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این متاآنالیز نشان‌دهنده افزایش خطر ابتلا به سرطان‌های آندومتر و تخمدان در بیماران مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بود.</span></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:12pt"><span sans-serif=""><b><span new="" roman="" times="">Background:</span></b><span new="" roman="" times=""> Although several studies have evaluated the risk of gynecological cancers in women with polycystic ovary syndrome (PCOS), there are controversies regarding it. </span></span></span><br> <span style="font-size:12pt"><span sans-serif=""><b><span new="" roman="" times="">Objective:</span></b><span new="" roman="" times=""> This study aimed to investigate the association of PCOS with endometrial, ovarian, and breast cancers.<b> </b></span></span></span><br> <span style="font-size:12pt"><span sans-serif=""><b><span new="" roman="" times="">Materials and Methods: </span></b><span new="" roman="" times="">PubMed, Scopus, Web of Science, and Google Scholar</span><span new="" roman="" times=""> databases based on MESH terms using the combination of the appropriate keywords were searched to retrieve observational studies on endometrial, ovarian, and breast cancers in PCOS women, published from inception to April 2020. This </span><span new="" roman="" times="">meta-analysis was performed to determine the pooled odds ratio (OR) of these cancers in women with PCOS. Publication bias was assessed by using Begg&rsquo;s test.</span></span></span><br> <span style="font-size:12pt"><span sans-serif=""><b><span new="" roman="" times="">Results:</span></b><span new="" roman="" times=""> Of 1347 records retrieved by searching the databases, a total of 14 articles were included in the study. Overall, the pooled OR of the composite outcome, including endometrial, ovarian, and breast cancers in women with PCOS was higher than that of women with no PCOS (pooled OR: 1.4, 95% CI: 1.0-1.9). The pooled OR of endometrial (pooled OR: 2.2, 95% CI: 1.03-4.7) and ovarian (pooled OR: 1.3, 95% CI: 1.0-1.8) cancers in women with PCOS was higher than the control group, whereas the pooled OR of breast cancer was not significantly higher than that of the control group. </span></span></span><br> <span style="font-size:12pt"><span sans-serif=""><b><span new="" roman="" times="">Conclusion: </span></b><span new="" roman="" times="">This meta-analysis indicated an increased risk of endometrial and ovarian cancers in women with PCOS. </span></span></span></span></div> سندرم تخمدان پلی کیستیک, سرطان آندومتر, سرطان تخمدان, سرطان پستان. Polycystic ovary syndrome, Endometrial cancer, Ovarian cancer, Breast cancer. 893 914 http://ijrm.ir/browse.php?a_code=A-10-1861-1&slc_lang=en&sid=1 Mina Amiri mina_amiri_p@yahoo.com 0000-0002-1126-9297 No Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Razieh Bidhendi-Yarandi razi_bidhendi@yahoo.com 0000-0002-2533-167X No Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Aida Fallahzadeh fallah_aida@yahoo.com 0000-0003-4641-0980 No Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. School of Medicine, Tehran University of Medical Science, Tehran, Iran. Zahra Marzban drzahrarad567@gmail.com 0000-0002-6440-1271 No Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fahimeh Ramezani Tehrani fah.tehrani@gmail.com 0000-0002-4609-065X Yes Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.