en Reproductive Urology Original Article Original Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">Background:</span></span></b><span lang="EN" style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> Herbal medicine could be effective at treating various illnesses. H</span></span><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">y</span></span><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">steroscopy can be as an effective method for assessing the uterus in terms of anatomical, physiological and pathological anomalies.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">Objective:</span></span></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> This study aims to evaluate the effect of evening primrose oil (EPO) on cervical preparation in women candidates for hysteroscopy<span style="background:#f8f9fa"><span style="color:black">.</span></span><span style="background:#f8f9fa"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> This study was a double-blind, randomized controlled clinical trial including 160 women candidates for diagnostic hysteroscopy who were referred to Al-zahra hospital from August 2019-March 2020. They were divided in 2 groups. Group A received 100 mg EPO as a soft gel capsule 6 hr before the hysterectomy in the</span></span><span lang="EN" style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> posterior vaginal fornix.</span></span><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> Group B received a placebo. After receiving the treatment, primary and secondary outcomes were evaluated in gropus.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">Results: </span></span></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">The average Hegar size in the EPO group was larger than in the control group (p < 0.001, for both). Also, the need for mechanical dilation, the time taken until the first resistance and the time of dilatation completion in the EPO group were significantly less than in the placebo group (p < 0.008 for all). There was also greater ease of dilatation in the EPO group. Side effects such as uterine rupture, false passage, cervical rupture, allergic reaction, abdominal pain, nausea, diarrhea, headache and increase of bowel movements were not reported in any cases.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">Conclusion:</span></span></b><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> Based on </span></span><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif">the</span></span><span style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> findings of the present study, EPO</span></span><span lang="EN" style="font-size:12.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"> is effective for cervical preparation in women undergoing hysteroscopy.</span></span></span></span></span><br> <p></p></div> Hysteroscopy, Dilatation, EPOGAM, Gamma-linolenic acid. 591 600 http://ijrm.ir/browse.php?a_code=A-10-1965-1&slc_lang=en&sid=1 Mandana Mansour Ghanaei m_m_ghanaie@ yahoo.com 0000-0003-1503-3502 No Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Maryam Asgharnia Maryamasgharnia@yahoo.com 0000-0002-6950-7542 No Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran. Maryam Farokhfar sfarrokhfar@yahoo.com 0000-0003-4006-4474 No Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Seyed Mohammah Asghari Ghalebin SMohammad.asgari17@yahoo.com 0000-0002-6464-197X No Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Elahe Rafie rafiee.elahe@yahoo.com 0000-0003-3220-3884 No Razi Clinical Research Development Unit, Guilan University of Medical Science, Rasht, Iran. Katayoun Haryalchi K_haryalchi@yahoo.com 0000-0001-8012-9952 Yes Reproductive Health Research Center, Department of Obstetrics and Gynecology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.