en بارداری پس از لقاح آزمایشگاهی در یک زن با سن بالا مبتلا به سندرم شرشفسکی-ترنر: گزارش یک مورد Pregnancy Health Case Report Case Report <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> سندرم </span></span><span dir="LTR" style="font-size:10.0pt">Shereshevsky-Turner</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">یک بیماری کروموزومی است که به دلیل فقدان کامل یا جزئی </span></span><span dir="LTR" style="font-size:10.0pt">X-monosomy</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در تمام یا بخشی از سلول&shy;های بدن، زنان را تحت تأثیر قرار می&shy;دهد. سندرم </span></span><span dir="LTR" style="font-size:10.0pt">Shereshevsky-Turner</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> با اختلالات شدید هورمونی و نقص در سیستم قلبی عروقی و ادراری مشخص می&shy;شود. با ظهور فناوری کمک باروری (</span></span><span dir="LTR" style="font-size:10.0pt">ART</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، بارداری برای این گروه از موارد، اغلب با تخمک</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">های اهدایی، قابل دسترس</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تر شده است. در مقالات موجود، یافتن اطلاعات دقیق در مورد طول زمان انتخاب حمایت پروژسترون، مدت زمان انتخاب و مدت قطع مصرف ممکن نبود.</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مورد:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> این مورد یک زن 36 ساله بدون فرزند است که از </span></span><span dir="LTR" style="font-size:10.0pt">STs</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، کاریوتایپ موزاییکی متشکل از 3 کلون: (69) </span></span><span dir="LTR" style="font-size:10.0pt">X</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">45، (8)</span></span><span dir="LTR" style="font-size:10.0pt">XXX </span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">47, (23)</span></span><span dir="LTR" style="font-size:10.0pt">XX</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">46 و 1000 هسته اینترفاز رنج می‌برد. در این مورد، ما دوزهای نگهدارنده بالای پروژسترون را به دلیل استفاده از </span></span><span dir="LTR" style="font-size:10.0pt">ART</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و پاتولوژی خارج تناسلی همزمان ترک کردیم که منجر به کاهش همه عملکردهای جفت شد. زن قبل، حین و بعد از بارداری تحت نظر قرار گرفت. او در 37 هفته و 6 روز بارداری فرزند خود را به دنیا آورد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه &shy;گیری:</span></span></b> <span dir="LTR" style="font-size:10.0pt">ART</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">احتمال حاملگی و بارداری را در مواردی با طیف وسیعی از آسیب‌شناسی‌های تناسلی و خارج تناسلی افزایش می‌دهد.</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span> <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span new="" roman="" style="font-family:" times=""><strong>Background: </strong><em><span lang="RU" style="font-style:normal">Shereshevsky-Turner Syndrome</span></em> is a chromosomal condition that affects females owing to full or partial missing of X-monosomy in all or part of the body&#39;s cells. Shereshevsky-Turner Syndrome is characterized by severe hormonal disorders and defects of the cardiovascular and urinary systems. With the advent of assisted reproductive technology (ART), pregnancy has become more accessible for this group of cases, often with donor eggs. In the available literature, it was not possible to find exact information during the time of selection of progestogen support, the duration of the appointment, and the term of withdrawal.</span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span new="" roman="" style="font-family:" times=""><strong>Case presentation:</strong> This is the case of a 36-yr-old primigravid woman suffering from STs, mosaic karyotype comprising of 3 clones: 45X (69), 46XX (23), 47XXX (8), and 1000 interphase nuclei. In this case, we left high-maintenance doses of progesterone due to the application of ART and concomitant extragenital pathology, leading to a decrease in all functions of the placenta, including the endocrine. The woman was monitored before, during, and after the pregnancy. She was delivered at 37 wk and 6 days of gestation.</span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span new="" roman="" style="font-family:" times=""><strong>Conclusion:</strong> ART increases the possibility of having a pregnancy and gestation in cases with a wide variety of genital and extragenital pathologies.</span></span></span></div> سندرم ترنر, بارداری, ناباروری, هیپوگنادیسم, پروژسترون. Turner syndrome, Pregnancy, Infertility, Hypogonadism, Progesterone. 83 88 http://ijrm.ir/browse.php?a_code=A-10-2041-1&slc_lang=en&sid=1 Perizat Saparbaevna Sadykova Sadykova_P@bk.ru 0000-0003-2494-8333 No Medicine Department, Al-Farabi Kazakh National University, Almaty, Kazakhstan. Sholpan Kuanyshbekovna Sarmuldayeva sara_@mail.ru 0000-0001-7122-4480 No Medicine Department, Al-Farabi Kazakh National University, Almaty, Kazakhstan. Galina Kalievna Kausova G.Kausova@ksph.kz 0000-0001-6857-9563 No Kazakhstan’s Medical University, Almaty, Kazakstan. Elvira Shukenova shukenova-elvira@mail.ru 0000-0002-1456-0047 No Obstetrics Department Maternity Hospital, Almaty, Kazakhstan. Linas Rovas linas.rovas@gmail.com 0000-0002-2159-6056 Yes Klaipeda University Hospital, Klaipeda University, Lithuania.