en رابطه بین ریزمغذی‌های غذایی و آندومتریوز: یک مطالعه مورد- شاهدی Reproductive Endocrinology Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">علت آندومتریوز به خوبی شناخته نشده است و مطالعات کمی در مورد دریافت ریز مغذی&shy;ها در زنان مبتلا به آندومتریوز انجام شده است.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه با هدف بررسی ارتباط بین ریز مغذی‌های رژیم غذایی و خطر ابتلا به آندومتریوز انجام شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش &shy;ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه مورد-شاهدی بر روی زنان 18 تا 45 ساله مبتلا به آندومتریوز و نیز بدون آندومتریوز در درمانگاه زنان بیمارستان آرش از اردیبهشت 1396 تا اردیبهشت 1397 در تهران انجام شد. بر اساس یافته های لاپاراسکوپی، شرکت کنندگان به دو گروه زنان مبتلا به آندومتریوز لگنی به عنوان گروه &nbsp;&nbsp;مورد (78 نفر) و زنان بدون آندومتریوز لگنی به عنوان گروه شاهد (78 نفر) تقسیم شدند. داده‌های رژیم غذایی با استفاده از پرسشنامه 168 سؤالی نیمه کمی بسامد غذا (</span></span><span dir="LTR" style="font-size:10.0pt">FFQ</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) استاندارد شده جمع‌آوری شد. برای تعیین ارتباط ریزمغذی&shy;ها و خطر ابتلا به آندومتریوز از مدل رگرسیون لجستیک استفاده شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تجزیه و تحلیل داده‌ها در مجموع نشان داد که بین ریزمغذی‌هایی مانند پتاسیم (99/0-56/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span> <span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،74/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">کلسیم (94/0-52/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span> <span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،70/0</span></span><span lang="FA" style="font-size:10.0pt"> :</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) و همچنین بین ویتامین‌ها، ویتامین </span></span><span dir="LTR" style="font-size:10.0pt">C</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> (94/0-52/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span> <span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،70/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، </span></span><span dir="LTR" style="font-size:10.0pt">B2</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> (98/0-55/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">CI</span><span style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> ،73/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، و </span></span><span dir="LTR" style="font-size:10.0pt">B12</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> (95/0-53/0</span></span><span lang="FA" style="font-size:10.0pt"> :</span> <span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،71/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) ارتباط معنی&shy;داری با آندومتریوز وجود دارد، بنابراین کسانی که از ریزمغذی&shy;های کمتر استفاده می&shy;کردند در معرض خطر بالاتر آندومتریوز قرار داشتند.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">یافته‌ها نشان داد که دریافت کلسیم، پتاسیم، ویتامین </span></span><span dir="LTR" style="font-size:10.0pt">B12</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، ویتامین </span></span><span dir="LTR" style="font-size:10.0pt">B2</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، ویتامین </span></span><span dir="LTR" style="font-size:10.0pt">B6</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، ویتامین </span></span><span dir="LTR" style="font-size:10.0pt">C</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> با خطر ابتلا به آندومتریوز رابطه معکوس دارد (94/0-52/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span> <span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،70/0 </span></span><span lang="FA" style="font-size:10.0pt">:</span><span dir="LTR" style="font-size:10.0pt">OR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">).</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Fewer studies were on micronutrient intake in women with endometriosis, and the etiology of endometriosis remains unclear between dietary micronutrients and the risk of endometriosis.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This study aimed to investigate the relationship between dietary micronutrients and the risk of endometriosis. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This case-control study was conducted on 156 women (18-45 yr) with and without endometriosis in the gynecology clinic of Arash hospital between May 2017 and May 2018 in Tehran, Iran. According to the laparoscopic findings, the participants were divided into 2 groups (n = 78/each), women with pelvic endometriosis as the case group and women without endometriosis pelvic as the control group. Dietary data were collected using a validated 168-item semiquantitative food frequency questionnaire with the standard serving. A logistic regression model was used to determine the association between micronutrients and the risk of endometriosis. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Data analysis showed a significant relationship between micronutrients such as: potassium (OR: 0.74; CI: 0.56-0.99; p = 0.01), calcium (OR: 0.70; CI: 0.52-0.94; p = 0.003), and also among the vitamin C (OR: 0.70; CI: 0.52-0.94; p = 0.02), B2 (OR: 0.73; CI: 0.55-0.98; p = 0.01), and B12 (OR: 0.71; CI: 0.53-0.95; p = 0.02) with endometriosis, so those who used fewer micronutrients were at higher risk of endometriosis. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The findings showed that the dietary intakes of calcium, potassium, vitamins B12, B2, B6, and C are inversely related to the risk of endometriosis.</span></span></span></span></span></div> رژیم غذایی, آندومتریوز, پرسشنامه, ریز مغذی ها. Diet, Endometriosis, Food questionary, Micronutrients. 333 342 http://ijrm.ir/browse.php?a_code=A-10-2099-1&slc_lang=en&sid=1 Ghazal Roshanzadeh roshanzadeh.g@iums.ac.ir 0000-0002-0665-5409 No Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Shahideh Jahanian Sadatmahalleh shahideh.jahanian@modares.ac.ir 0000-0002-7006-8487 Yes Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Ashraf Moini ashraf.moeini@gmail.com 0000-0002-5074-2286 No Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Azadeh Mottagh mottaghi.a@iums.ac.ir 0000-0002-1325-8946 No Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. Farahnaz Rostami farahnaz.rostami@modares.ac.ir 0000-0001-9287-2620 No Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.