International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1401
5
1
gregorian
2022
8
1
20
8
online
1
fulltext
en
بررسی ارتباط پارامترهای کلینیکی و آزمایشگاهی و سقط زودرس در روش های کمک باروری: یک مطالعه ی مقطعی
Correlation between clinical and laboratory parameters and early pregnancy loss in assisted reproductive technology cycles: A cross-sectional study
Assisted Reproductive Technologies
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">میزان سقط جنین پس از بارداری ناشی از فناوری کمک­باروری (</span></span><span dir="LTR" style="font-size:10.0pt">ART</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) حدود 20% است که حدود نیمی از آن بیوشیمیایی است. ارتباط بین تعداد و کیفیت تخمک­ها، سطح استرادیول و سقط زودرس تاکنون کاملاً مشخص نیست.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه با هدف بررسی اثرات پارامترهای بالینی و آزمایشگاهی بر سقط زودرس در سیکل­های </span></span><span dir="LTR" style="font-size:10.0pt">ART</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">انجام شده است.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش ­ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در این مطالعه مقطعی 480 زن کاندید </span></span><span dir="LTR" style="font-size:10.0pt">ART</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و مراجعه</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">­</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">کننده به مرکز تحقیقات درمانی ناباروری یزد، ایران طی اسفند 1396 تا اسفند 1399 که تحت انتقال جنین تازه قرار گرفته بودند و آزمایش سرم بتای گنادوتروپین جفتی انسانی مثبت بود وارد مطالعه شدند. سطح </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، کیفیت جنین، تعداد تخمک، سطح پروژسترون و استرادیول و سن مادر از پرونده­های آنها استخراج شد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تفاوت معنی­داری بین سن، میانگین سطح استرادیول و پروژسترون در روز تریگر، تعداد تخمک­های </span></span><span dir="LTR" style="font-size:10.0pt">MII</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، کیفیت جنین در گروه­های حاملگی بالینی مثبت و سقط زودرس وجود نداشت. به ترتیب (20/0، 34/0، 07/0، 42/0، 19/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تفاوت آماری معنی­داری بین سه گروه </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مشاهده نشد (20/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) اما پس از ارزیابی با استفاده از آزمون رگرسیون لجستیک, میزان حاملگی­های بالینی منفی در گروه </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">زیر 1 بیشتر بود، اگرچه از نظر آماری معنی</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">­</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">دار نبود.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه­ گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">ما هیچ ارتباطی بین سقط زودرس و سطح </span></span><span dir="LTR" style="font-size:10.0pt">AMH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، کیفیت جنین، تعداد تخمک، سطح پروژسترون و استرادیول و سن مادر پیدا نکردیم.</span></span></span></span></span></span></span><br>
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</div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><span style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white">Background: </span></span></strong><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The miscarriage rate after pregnancy resulting from assisted reproductive technology (ART) is about 20%, roughly half of which is biochemical. The correlations between the number and quality of oocytes, estradiol level and early pregnancy loss have not been fully clarified.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><span style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white">Objective:</span></span></strong><span style="font-size:12.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""> This study aimed to examine the clinical and laboratory parameter effects on early abortion in ART cycles. </span></span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><span style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white">Materials and Methods: </span></span></strong><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">In this cross-sectional study, 408 women who were ART candidates and were referred to the Yazd Infertility and Research Center, Yazd, Iran during March 2017 to March 2020 participated. Women who had a fresh embryo transferred and who had a positive beta human chorionic gonadotropin serum test were included in the study. The Anti-Müllerian hormone (AMH) level, embryo quality, oocyte number, progesterone level, estradiol level, and maternal age were extracted from the medical records.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><strong><span style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white">Results:</span></span></strong><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> No significant difference was observed in the age, mean estradiol </span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">and progesterone levels on trigger day</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">, number of MII oocytes, and embryo quality between the groups (p = 0.19, 0.42, 0.07, 0.34 and 0.20, respectively). No statistically significant difference was found between the 3 groups of AMH level (p = 0.20). After evaluation using logistic regression, the rate of negative clinical pregnancies was higher in the group with AMH < 1 ng/ml. However, this was not found to be statistically significant.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:none"><span sans-serif="" style="font-family:Calibri,"><strong><span style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white">Conclusion:</span></span></strong> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">We did not find any correlation between early abortion and AMH levels, embryo quality, oocyte number, progesterone level, estradiol level, or maternal age.</span></span></span></span></span></span></div>
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سقط, حاملگی, انتقال جنین, روشهای کمک باروری, آنتی مولرین هورمون.
Abortion, Pregnancy, Embryo transfer, Assisted reproductive techniques, Anti-Müllerian hormone.
683
690
http://ijrm.ir/browse.php?a_code=A-10-2131-1&slc_lang=en&sid=1
Fatemeh
Emami
miss.dremami@gmail.com