en ﻣﻘﺎیﺴﻪ ﻧﺘﺎیﺞ حاملگی در اﻧﺘﻘﺎل ﺟﻨﯿﻦ ﺗﺎزه و فریز شده: یک مطالعه مقطعی Fertility & Infertility Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">فوائد روش انتقال جنین فریز شده در برابر انتقال جنین تازه برای انجام </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در مطالعات پیشین مورد بحث بوده است.<b> </b></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تعیین و مقایسه نتایج حاملگی بدنبال انتقال جنین&shy;های تازه و فریز شده در زنان تحت درمان با روش&shy;های کمک باروری.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">233 خانم مراجعه&shy;کننده به مرکز درمان ناباروری بیمارستان کمالی کرج در طی سال&shy;های 1399-1398</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">که تحت درمان </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">بودند به دو گروه جنین&shy;های تازه (127 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) و جنین&shy;های فریز شده (106 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) در سیکل&shy;های درمان با روش&shy;های کمک باروری تقسیم شدند. نرخ پیامدهای حاملگی مشتمل بر حاملگی شیمیایی و بالینی، تولد زنده، پری&shy;اکلامپسی، حاملگی اکتوپیک، مرده&shy;زایی و سقط در این دو گروه و به تفکیک سه گروه سنی زیر 25، 35-25 و 40-35 سال انجام شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در زنان زیر 25 سال، تفاوت معنی&shy;داری در خصوص نرخ حاملگی شیمیایی و بالینی و تولد زنده مشاهده نشد. در زنان 35-25 سال، نرخ حاملگی شیمیایی و بالینی و تولد زنده در گروه جنین&shy;های فریز شده در مقایسه با گروه جنین&shy;های تازه به&shy;طور معنی&shy;داری بالاتر بود (به ترتیب 01/0، 03/0 و 01/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">). در زنان&nbsp;&nbsp;&nbsp; &nbsp;40-35 ساله، تفاوت معنی&shy;داری در نرخ حاملگی شیمیایی و بالینی مشاهده نشد اما نرخ تولد زنده در گروه جنین&shy;های فریز شده به&shy;طور معنی&shy;داری بالاتر بود&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (02/0 </span></span><span lang="FA" style="font-size:10.0pt">=</span> <span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">). میزان سقط در گروه جنین&shy;های فریز شده کمتر بود (038/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">).</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج مطالعه ما نشان داد، روش جنین فریز شده در زنان 35-25 سال، شانس موفقیت </span></span><span dir="LTR" style="font-size:10.0pt">IVF/ICSI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> را به&shy;طور معنی&shy;داری افزایش می&shy;دهد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span calibri="" light=""><span style="font-weight:bold"><span style="font-size:11.5pt"><span new="" roman="" times="">Background: </span></span><span style="font-size:11.5pt"><span new="" roman="" times=""><span style="font-weight:normal">The benefits of frozen embryo transfer (FET) vs. fresh embryo transfer for in vitro fertilization (IVF) have been discussed in previous studies. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" light=""><span style="font-weight:bold"><span style="font-size:11.5pt"><span new="" roman="" times="">Objective: </span></span><span style="font-size:11.5pt"><span new="" roman="" times=""><span style="font-weight:normal">To determine and compare the pregnancy outcomes following FET and frozen embryos transfer in women who underwent assisted reproductive techniques.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" light=""><span style="font-weight:bold"><span style="font-size:11.5pt"><span new="" roman="" times="">Materials and Methods: </span></span><span style="font-size:11.5pt"><span new="" roman="" times=""><span style="font-weight:normal">In this cross-sectional study, 233 women candidates for IVF/intra cytoplasmic sperm injection who referred to the Kamali Training Medical Center, Karaj, Iran during 2019-2020 were evaluated in 2 groups of fresh (n = 127) and frozen (n = 106) embryo transfers. The rates of pregnancy outcomes including chemical and clinical pregnancy, live birth, preeclampsia, ectopic pregnancy, still birth, and pregnancy loss were compared between groups in 3 age subgroups (< 25, 25-35, and 35-40 yr old).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" light=""><span style="font-weight:bold"><span style="font-size:11.5pt"><span new="" roman="" times="">Results: </span></span><span style="font-size:11.5pt"><span new="" roman="" times=""><span style="font-weight:normal">No significant difference in terms of chemical and clinical pregnancy and live birth rates were observed between groups in women aged < 25 yr. Chemical and clinical pregnancy and live birth rates were significantly higher in the FET group compared to fresh group in 25-35-yr-old women (p = 0.01, p = 0.03, and p = 0.01, respectively). In 35-40-yr-old women, no significant differences were observed in terms of chemical and clinical pregnancy rates, but live birth rate was found to be significantly higher in the FET group (p = 0.02). The pregnancy loss was lower in the FET group (p = 0.038).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" light=""><span style="font-weight:bold"><span style="font-size:11.5pt"><span new="" roman="" times="">Conclusion: </span></span><span style="font-size:11.5pt"><span new="" roman="" times=""><span style="font-weight:normal">In conclusion, the FET method in women aged 25-35 yr significantly increases the chance of successful IVF/intra cytoplasmic sperm injection. </span></span></span></span></span></span></span></span></div> روش­های کمک باروری, لقاح داخل رحمی, انتقال جنین, انجماد, ارزیابی نتایج. Assisted reproductive techniques, In vitro fertilization, Embryo transfer, Cryopreservation, Outcome assessment. 551 556 http://ijrm.ir/browse.php?a_code=A-10-2144-1&slc_lang=en&sid=1 Ramesh Baradaran Bagheri dr.rameshbb@gmail.com 0000-0002-9853-6799 Yes Department of Obstetrics and Gynecology, Alborz University of Medical Sciences, Karaj, Iran. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Mahshid Bazrafkan 0000-0001-6725-3430 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Abbas Sabour 0000-0002-5149-6240 No Alborz University of Medical Sciences, Karaj, Iran. Mina Ataei 0000-0002-0935-7837 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Department of Obstetrics and Gynecology, Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran. Bita Badehnoosh 0000-0001-8469-8378 No Department of Obstetrics and Gynecology, Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran. Banafsheh Mashak 0000-0003-1057-7041 No School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Bahareh Khakifirooz 0000-0001-8186-3999 No Department of Obstetrics and Gynecology, School of Medicine, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran. Ramin Moghaddam 0000-0002-8041-8655 No International Academy of Health Sciences Informatics (IAHSI), Geneva, Switzerland.