en مقایسه تأثیر کرم واژینال استروژن و کرم واژینال شرین بیان در عملکرد جنسی زنان یائسه: یک کارآزمایی بالینی Reproductive Epidemiology Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">یائسگی مرحله&shy;ای از زندگی زنان است که برخی از زنان در میانسالی و برخی در سنین پایین&shy;تر (یائسگی زودرس) آن را تجربه می&shy;کنند. سطوح پایین هورمون&shy;های تخمدان در دوران یائسگی می&shy;تواند منجر به عوارض مختلفی شود. یائسگی یکی از عواملی است که می&shy;تواند بر عملکرد جنسی زنان تأثیر بگذارد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">مطالعه حاضر با هدف مقایسه تأثیر کرم واژینال شیرین&shy;بیان و کرم واژینال استروژن بر عملکرد جنسی زنان یائسه انجام شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">مواد و روش &shy;ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">در این مطالعه کارآزمایی بالینی تصادفی، 82 زن یائسه مراجعه&shy;کننده به مراکز بهداشتی درمانی شهر ایلام از تیر تا آبان 1399 به طور تصادفی به 2 گروه (هر کدام 41 نفر) تقسیم شدند. به یک گروه کرم واژینال استروژن 2% و به گروه دیگر کرم شیرین&shy;بیان واژینال 2% داده شد. شرکت&shy;کنندگان از 2 دارو برای دوره&shy;های 14 روزه استفاده کردند. ما از روش تصادفی محدود استفاده کردیم. پرسشنامه&shy;های جمع&shy;آوری داده&shy;ها شامل پرسشنامه اطلاعات دموگرافیک قبل از درمان و پرسشنامه شاخص عملکرد جنسی زنان قبل، یک ماه پس از مصرف دارو و 2 ماه پس از مصرف دارو تکمیل شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">میانگین نمره عملکرد جنسی در گروه شیرین&shy;بیان 37/4</span></span> <span lang="FA" style="font-size:10.0pt">&plusmn;</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">86/17 و در پایان مطالعه به 63/4</span></span><span lang="FA" style="font-size:10.0pt"> &plusmn;</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">31/20 افزایش یافت، میانگین نمره عملکرد جنسی در گروه استروژن 99/3</span></span><span lang="FA" style="font-size:10.0pt"> &plusmn; </span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">14/17 و در پایان به 09/5</span></span><span lang="FA" style="font-size:10.0pt"> &plusmn; </span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">97/22 افزایش یافت (015/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">).</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">نتیجه &shy;گیری:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">تأثیر کرم واژینال استروژن بر عملکرد جنسی زنان یائسه بیشتر از کرم واژینال شیرین&shy;بیان بود.</span></span></span></span></span></span></span><br> &nbsp;</div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Background:</span></b><span style="font-size:12.0pt"> Menopause is a stage in woman&rsquo;s life that some women experience in middle age and some at a younger age (premature menopause). Low levels of ovarian hormones, during menopause can lead to various complications. Menopause is one of the factors that can affect a woman&#39;s sexual function. </span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Objective:</span></b><span style="font-size:12.0pt"> The present study was conducted to compare the effect of licorice vaginal cream and estrogen vaginal cream on the sexual function of postmenopausal women.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Materials and Methods:</span></b><span style="font-size:12.0pt"> In this randomized clinical trial study, 82 postmenopausal women</span> <span style="font-size:12.0pt">who were referred to health centers in Ilam, Iran from July to November 2020 were randomly divided into 2 groups (n = 41/each). One group was given estrogen vaginal cream 2%, and the other vaginal licorice cream 2%. Participants used the 2 medications for 14-day periods each. <span style="background:white">We used the finite randomization method</span>. Data collection questionnaires, including a demographic information questionnaire before treatment and a female sexual function index questionnaire were completed before, one month after the medication, and 2 months after using the medication.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Results:</span></b><span style="font-size:12.0pt"> The mean score of sexual function in the licorice group was 17.86 &plusmn; 4.37 and increased to 20.31 &plusmn; 4.63 at the end of the study. The mean score of sexual function in the estrogen group was 17.14 &plusmn; 3.99 and increased to 22.97 &plusmn; 5.09 at the end of study (p = 0.015).</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:12.0pt">Conclusion:</span></b><span style="font-size:12.0pt"> The effect of estrogen vaginal cream on the sexual function of postmenopausal women was greater than licorice vaginal cream.</span></span></span></span></span><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:14.0pt"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"></span></span></span></span></span></span></div> واژن, یائسگی, زنان, شیرین بیان, استروژن. Vagina, Post menopause, Glycyrrhiza, Estrogens. 963 972 http://ijrm.ir/browse.php?a_code=A-10-2159-1&slc_lang=en&sid=1 Parisa Ahmadizad p.ahmadizad@gmail.com 0000-0003-4556-6342 No Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran. Masoumeh Shohani msh282000@gmail.com 0000-0001-6865-3129 Yes Department of Nursing, School of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran. Ashraf Direkvand Moghadam direkvand-a@medilam.ac.ir 0000-0003-1789-4373 No Department of Midwifery, School of Nursing and Midwifery, Ilam University of Medical Sciences, Ilam, Iran. Anahita Jalilian Jalilian_a@medilam.ac.ir 0000-0002-3417-985x No Department of Obstetrics and Gynecology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Hojat Sayadi sayadi_h@medilam.ac.ir 0000-0002-8348-3604 No Department of Biostatistics, School of Health, Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran. Naser Abbasi Abbasi_n@medilam.ac.ir 0000-0003-4457-3997 No Department of Pharmacology, School of Medicine, Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.