en بررسی میزان سطح سرمی پرپتین در زنان مبتلا به سندرم تخمدان پلی کیستیک: مروری سیستماتیک و متاآنالیز Reproductive Pattology Review article Review Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> سندرم تخمدان پلی‌کیستیک (</span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">یک اختلال غدد درون‌ریز رایج با بیماری‌زایی نامشخص و عوارض متابولیکی مانند مقاومت به انسولین است. در میان نشانگرهای جدید، به نظر می</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">رسد پرپتین نقش مهمی در اختلالات متابولیک ایفا می&shy;کند.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> این بررسی متاآنالیز به منظور تعیین ارتباط بین سطوح پرپتین سرم و</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">انجام شد</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">.</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش‌ها:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> یک بررسی سیستماتیک و متاآنالیز برای شناسایی مقالات مناسب فهرست ‌شده در پایگاه‌های اطلاعاتی الکترونیکی مانند&nbsp;</span></span><span dir="LTR" style="font-size:10.0pt">PubMed</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،</span></span><span dir="LTR" style="font-size:10.0pt">Web</span> <span dir="LTR" style="font-size:10.0pt">of Science </span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt">Scopus</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt">Cochrane</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">،</span></span><span dir="LTR" style="font-size:10.0pt">EMBASE</span> <span style="font-size:11.0pt"><span b="" mitra="" style="font-family:">&nbsp;و موتور جستجوی</span></span> <span dir="LTR" style="font-size:10.0pt">Google Scholar</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">با استفاده از استراتژی جستجو از پیش تعیین شده، انجام شد. یک مدل اثرات تصادفی با میانگین تفاوت استاندارد (</span></span><span dir="LTR" style="font-size:10.0pt">SMD</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) و فاصله اطمینان 95</span></span><span lang="FA" style="font-size:11.0pt"><span majalla="" sakkal="" style="font-family:">٪</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> (</span></span><span dir="LTR" style="font-size:10.0pt">CI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">برای مقایسه نتایج بین گروه‌ها انجام شد. متارگرسیون و تجزیه و تحلیل زیر گروهی نیز برای نشان دادن ناهمگنی انجام شد</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">.</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> در مجموع 582 شرکت‌کننده از هشت مقاله، در بررسی متاآنالیز وارد شدند. ما یک رابطه معنی‌دار بین</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و سطوح پرپتین سرم، با تفاوت میانگین استاندارد ادغام‌شده شناسایی کردیم (0001/0</span></span><span lang="FA" style="font-size:10.0pt"> > </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:10.0pt">،</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> 08/2-63/0</span></span><span lang="FA" style="font-size:10.0pt"> :</span><span dir="LTR" style="font-size:10.0pt">CI</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">95%</span></span><span lang="FA" style="font-size:10.0pt">، </span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">35/1</span></span><span lang="FA" style="font-size:10.0pt"> = </span><span dir="LTR" style="font-size:10.0pt">SMD</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) همچنین، تفاوت معنی&shy;داری بین سطوح پرپتین سرم در بیماران مبتلا به</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و نسبت بالای</span></span> <span dir="LTR" style="font-size:10.0pt">HOMA-IR</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">وجود دارد (0001/0</span></span><span lang="FA" style="font-size:10.0pt"> > </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:10.0pt">، </span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">63/3-17/1</span></span><span lang="FA" style="font-size:10.0pt"> :</span><span dir="LTR" style="font-size:10.0pt">CI</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">95%</span></span><span lang="FA" style="font-size:10.0pt">، </span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">40/2</span></span><span lang="FA" style="font-size:10.0pt"> = </span><span dir="LTR" style="font-size:10.0pt">SMD</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)</span></span><span lang="FA" style="font-size:10.0pt">.</span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه‌گیری:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بررسی متاآنالیز ما نشان می‌دهد که افزایش سطح پرپتین سرم با</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مرتبط است، که این مسئله نشان می‌دهد پرپتین ممکن است با پاتوژنز</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مرتبط باشد و احتمالا به عنوان یک نشانگر تشخیصی جدید برای</span></span> <span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">درنظر گرفته شود. با این حال، مطالعات بیشتری برای تأیید نتایج ما مورد نیاز است</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">.</span></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Background:</b> Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Objective: </b>This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Materials and Methods:</b> A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Results: </b>The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p < 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p < 0.001) within the subgroup.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.</span></span></div> سندرم تخمدان پلی‌کیستیک, فاکتور رشد شبه ‌انسولینی II, پرپتین, متاآنالیز. Polycystic ovary syndrome, Proinsulin-like growth factor II, Preptin, Meta-analysis. 367 378 http://ijrm.ir/browse.php?a_code=A-10-2313-2&slc_lang=en&sid=1 Seyed Sobhan Bahreiny bahreiny.s@ajums.ac.ir 0000-0003-2148-1205 Yes Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Elnaz Harooni elnazharooni@gmail.com 0000-0002-0775-7933 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Reza Dabbagh dabbagh200@gmail.com 0000-0001-8771-0846 No Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Reza Ebrahimi Reza1997ebra@gmail.com 0000-0001-7632-3162 No Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran.