International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1402
7
1
gregorian
2023
10
1
21
10
online
1
fulltext
en
حاملگی حاصل از لقاح آزمایشگاهی ممکن است باعث تحلیل حجم تیموس جنین شود: یک مطالعه مورد-شاهدی
In vitro fertilization pregnancy may cause fetal thymic volume involution: A case-control study
Perinatology
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">تأثیر روشهای مدرن درمان ناباروری بر حجم تیموس جنین به خوبی شناخته نشده است.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">حجم 3 بعدی (</span></span><span dir="LTR" style="font-size:10.0pt">D</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">3) تیموس جنین 18 تا 24 هفته حاملگی حاصل از لقاح آزمایشگاهی (</span></span><span dir="LTR" style="font-size:10.0pt">IVF</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) با موارد حاملگی خود­به­خود مقایسه شد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش ­ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">در این مطالعه مورد-شاهدی آینده­نگر 135 مورد بررسی شدند. این مطالعه بین جولای 2019 و جولای 2020 در یک بیمارستان دانشگاهی در ترابزون ترکیه انجام شد. حجم تیموس جنین در خانم­های باردار که در مطالعه قرار گرفتند با کمک سیستم آنالیز کامپیوتری ارگان مجازی موجود در یک سیستم سونوگرافی پیشرفته محاسبه شد. حجم تیموس جنین بین زنان باردار با </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">و زنان باردار خود ­به­ خود مقایسه شد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">اندازه تیموس جنین در گروه حاملگی حاصل از </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نسبت به حاملگی خودبهخودی بهطور معنیداری کمتر بود (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">). نتایج مطالعه نشان داد که عوارض جنینی، مانند وضعیت سلامت غیرمطمئن جنین و نیاز به مراقبت­های ویژه نوزادان، در مواردی که پس از درمان </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">باردار شده بودند، بیشتر بود. همچنین مشخص شد که میزان هر گونه عارضه بارداری در گروه حاملگی </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> به طور معنیداری بیشتر بود (02/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">).</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">بر اساس نتایج این مطالعه شاید بتوان نتیجه گرفت که اندازه کوچک تیموس جنین ممکن است یکی دیگر از عوارض جنینی حاملگی حاصل از </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">باشد.</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Background: </span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">The effect of modern infertility treatment modalities on fetal thymic volume has not been well known. </span></span><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Objective:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> 3-dimensional (3D) fetal thymus volumes of 18-24 wk in vitro fertilization (IVF) pregnancies and spontaneous pregnancy cases were compared.</span></span><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> 135 cases were evaluated in this prospective case-control study. The study was conducted between July 2019 and July 2020 at a university hospital in Trabzon, Turkey. Fetal thymus volume was calculated in the pregnant cases included in the study with the help of the virtual organ computer-assisted analysis system included in the advanced ultrasonography system. The fetal thymus volumes were compared between pregnant women with IVF and spontaneous pregnant women.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Results: </span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">The fetal thymus size was significantly lower in the IVF pregnancy group than in spontaneous pregnancy cases (</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">p < 0.001)</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">. It was found that the fetal complications, such as non-reassuring fetal health status and requirement for neonatal intensive care, were higher in cases who became pregnant after IVF treatment. It was also found that the rate of any pregnancy complication was significantly higher in IVF pregnancy group (p = 0.02).</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Conclusion:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> In light of these results, it may be concluded that small fetal thymus size may be another fetal complication of IVF pregnancies.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></div>
جنین, لقاح آزمایشگاهی, سونوگرافی قبل از تولد, تیموس.
Fetus, Fertilization in vitro, Prenatal ultrasonography, Thymus.
819
826
http://ijrm.ir/browse.php?a_code=A-10-2384-2&slc_lang=en&sid=1
Nurgul Selin
Kaya
drsuleymanguven@yahoo.com