en آیا تجویز کلومیفن سیترات میزان موفقیت میکروتسه در مردان آزواسپرم غیرانسدادی را افزایش می‌دهد؟ یک مطالعه مورد شاهدی Fertility & Infertility Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">داروی کلومیفن برای افزایش شانس بازیابی اسپرم به روش استخراج میکروسکوپی اسپرم از بیضه (میکروتسه) پیشنهاد شده است.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه با هدف بررسی تأثیر کلومیفن بر نتایج میکروتسه به دلیل اختلاف نظر زیاد در این زمینه انجام شد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">112 شرکت&shy;کننده در این مطالعه مورد-شاهدی گذشته‌نگر وارد شدند و به دو گروه مورد (54 نفر) و کنترل (58 نفر) تقسیم شدند و آزمایش‌های هورمونی شامل هورمون محرک فولیکول (</span></span><span dir="LTR" style="font-size:10.0pt">FSH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، هورمون لوتئینی (</span></span><span dir="LTR" style="font-size:10.0pt">LH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، تستوسترون و پرولاکتین مورد تجزیه و تحلیل قرار گرفت. گروه مورد به مدت سه ماه روزانه 25 میلی&shy;گرم کلومیفن دریافت کردند و گروه کنترل دارویی دریافت نکردند، سپس همه مردان توسط متخصص آندرولوژی تحت میکروتسه قرار گرفتند و در پایان نتایج بین گروه&shy;ها مقایسه شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">میانگین سنی شرکت‌کنندگان در گروه مورد و شاهد یکسان بود، بین دو گروه رابطه معنی&shy;‌داری وجود نداشت، 9/25% از اسپرم&shy;ها و 0/31% از اسپرم&shy;ها به ترتیب در گروه تحت درمان با کلومیفن و گروه کنترل مشاهده و استخراج شدند (16/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">).</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">یافته‌های ما نشان داد که پس از دریافت کلومیفن سیترات، میزان استحصال اسپرم‌ افزایش نیافته و حتی کاهش نیز داشته است، با این وجود سطح اولیه هورمون‌های تستوسترون، </span></span><span dir="LTR" style="font-size:10.0pt">FSH</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt">LH</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">و پرولاکتین و همچنین سن، اندازه بیضه، مصرف سیگار و اعتیاد مردان به تریاک و بیماری‌های زمینه‌ای در دو گروه ارتباط معنی‌داری نداشتند و بر نتایج نیز تأثیری نداشتند.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:ideograph-other"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Clomiphene citrate (CC) has been suggested to increase the chance of sperm retrieval with</span></span><i> </i><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">microdissection testicular sperm extraction<i> </i></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">(micro-TESE).</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:ideograph-other"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">This study aimed to evaluate the effect of CC on micro-TESE results, due to the great controversy in this regard.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:ideograph-other"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> 112 participants were included in this cross-sectional study and were divided into a case (n = 54) and a control group (n = 58) diagnosed with non-abstractive azoospermia. The case group received 25 mg of CC daily for 3 months, while the control group did not receive anything. All participants underwent micro-TESE by an andrologist, and at the end, the results were compared between groups. Hormone tests, including follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin were analyzed. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:ideograph-other"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The mean age of participants was the same in the case and the control groups, and no significant relationship was observed between the 2 groups (p = 0.16). 25.9% of sperm and 31.0% of sperm were observed and extracted in the CC-treated and the control group, respectively. </span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="text-autospace:ideograph-other"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Our findings showed that after receiving CC, the number of sperm extraction did not increase but it rather decreased. However, the initial level of hormones such as testosterone, follicle-stimulating hormone, luteinizing hormone, and prolactin, and the men&#39;s age, testicle size, smoking, and opium addiction, underlying diseases had no significant relationship in the 2 groups and did not affect the results.</span></span></span></span></span></span></span></div> آزواسپرمی, کلومیفن, ناباروری مردان, استحصال اسپرم. Azoospermia, Clomiphene, Male infertility, Sperm retrieval. 943 948 http://ijrm.ir/browse.php?a_code=A-10-2366-1&slc_lang=en&sid=1 Serajoddin Vahidi vahidi.seraj@gmail.com 0000-0002-6195-4663 Yes Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mehdi Abedinzadeh abedinoro@yahoo.com 0000-0002-0027-3346 No Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Amirhossein Rahavian amirrahavian@yahoo.com 0000-0003-4173-2673 No Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Alimohammad Mirjalili aliaskari56@yahoo.com 0000-0002-8037-850X No Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Ali Sadeghi alisadeghi.b@gmail.com 0000-0002-8076-7628 No Department of Surgical Technology, Faculty of Paramedical, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hormoz Karami hormozkarami@yahoo.com 0000-0001-7384-2944 No Department of Urology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Saeid Abouei saeidabouei74@gmail.com 0000-0002-9412-4981 No Andrology Research Center, Yazd Reproductive Science Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.