en اثر ترکیب متی روزین/ پردنیزولون بر روی استئوپروز ناشی از برداشتن تخمدان Original Article Original Article <strong><span style="font-family:b mitra;">مقدمه:</span></strong><span style="font-family:b mitra;"> استئوپروز یک بیماری مزمن می&shy;&nbsp; باشد که مشخصه آن کاهش تراکم معدنی استخوان (</span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">BMD</span></span></span><span style="font-family:b mitra;">) و همچنین اختلال ساختمان میکروسکوپی بافت استخوانی می&shy;باشد.</span><br> <strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">هدف: </span></span></strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">بررسی اینکه آیا متیل پرونیزولون اثر مفیدی بر روی بافت استخوانی تحلیل رفته (استئوپروتیک) در موش&shy;هایی که تخمدان آن&shy;ها برداشته شده و همچنین سطح آدرنالین اندروژن آن&shy; ها بوسیله متی&shy;روزین مهار شده است دارد یا خیر؟</span></span><br> <strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">مواد و روش&shy;&nbsp; ها:</span></span></strong> <span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:times new roman,serif;"><span style="font-size:10pt;">BMD</span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">، تعداد استئوبلاست</span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;">-</span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">استئوکلات، سطح استئوکلسین استخوانی و آلکالین فسفاتاز (</span></span><span dir="LTR" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:times new roman,serif;"><span style="font-size:10pt;">ALP</span></span></span><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">)</span></span> <span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;">اندازه گیری و نتایج به دست آمده با نتایج آلندرونیت مقایسه شد. </span></span><br> <strong><span style="font-family:b mitra;">نتایج:</span></strong><span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;"><span style="font-family:b mitra;"> استوپروز ناشی از برداشتن تخمدان به وسیله متیل پرونیزولون تشدید شد. آلندرونیت از استئوپروز ناشی از برداشتن تخمدان پیشگیری کرد ولی قادر به جلوگیری از استئوپروز ناشی از برداشتن تخمدان همزمان با تجویز پرونیزولون در موش&shy; ها نبود.</span></span><br> <strong><span dir="RTL"><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه گیری:</span></span></span></strong><span dir="RTL"><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> <span style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-attachment:initial;background-origin:initial;background-clip:initial;">درمان ترکیبی متیل پرونیزولون و متی&shy;روزین بهترین درمان برای جلوگیری از استئوپروز بود ولی متی&shy;روزین به تنهایی قادر به جلوگیری از استئوپروز در موش&shy; هایی که تخمدان آن&shy;ها را برداشته شده بود، نبود.&nbsp;</span></span></span></span> &nbsp;&nbsp; <div><strong>Background:</strong> Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue.<br> <strong>Objective:</strong> It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine.<br> <strong>Materials and Methods:</strong> Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate.<br> <strong>Results:</strong> Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn&rsquo;t prevent methylprednisolone +ovariectomised induced osteoporosis in rats.<br> <strong>Conclusion:</strong> Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn&rsquo;t prevent osteoporosis in ovariectomised rats.</div> استئوپروز, متی روزین, متیل پرونیزولون, آلندرونیت, برداشتن تخمدان Osteoporosis, Metyrosine, Methylprednisolon, Alendronate, Ovariectomy 363 372 http://ijrm.ir/browse.php?a_code=A-10-31-72&slc_lang=en&sid=1 Suleyman Salman No Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey Serkan Kumbasar No Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey Ahmet Hacimuftuoglu No Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey Berna Ozturk No Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey Bedri Seven No Department of Nuclear Medicine, Ataturk University, Medical Faculty, Erzurum, Turkey Beyzagul Polat No Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey Cemal Gundogdu No Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey Elif Demirci No Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey Kadir Yildirim No Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum, Turkey Fatih Akcay No Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey Turan Uslu No Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey Ferrah Tuncel Daloglu No Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey Halis Suleyman halis.suleyman@gmail .com Yes Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey