en ارزش سندرم تحریک بیش از حد تخمدان همراه با هورمون های جنسی در پیش بینی پیامدهای لقاح آزمایشگاهی در زنان مبتلا به سندرم تخمدان پلی کیستیک: مطالعه مورد شاهدی Fertility & Infertility Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">سندرم تحریک بیش از حد تخمدان (</span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) به عنوان یک عارضه شناخته شده در زنان سندرم تخمدان پلی&shy;کیستیک (</span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) ممکن است به دنبال درمان&shy;های باروری القایی مانند لقاح آزمایشگاهی (</span></span><span dir="LTR" style="font-size:10.0pt">IVF</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) رخ دهد و همچنین می&shy;تواند عواقب این درمان&shy;های باروری را تحت تأثیر قرار دهد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف از این مطالعه بررسی اثرات </span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">بر پیامد بارداری مرتبط با </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در بیماران </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">بود. همچنین ارزش هورمون&shy;های جنسی پایه برای&nbsp;&nbsp; پیش&shy;بینی موفقیت بارداری ارزیابی شد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این مطالعه مورد-شاهدی بر روی 180 زن متوالی مبتلا به سندرم تخمدان پلی&shy;کیستیک کاندید </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در بیمارستان فاطمیه از تاریخ اردیبهشت تا تیر 1401 انجام شد. بیماران در گروه مورد (با </span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، 129 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) و گروه شاهد (بدون </span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، 51 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) قرار گرفتند. اندازه&shy;گیری هورمون</span></span><span lang="FA" style="font-size:11.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">های جنسی در بیماران با استفاده از </span></span><span dir="LTR" style="font-size:10.0pt">ELISA</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">انجام شد. </span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در مدل&shy;های رگرسیون لجستیک چند متغیره </span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتوانست احتمال بارداری بالینی یا شیمیایی را پس از </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">پیش&shy;بینی کند. هیچ یک از هورمون&shy;های جنسی پایه نمی&shy;توانند حاملگی شیمیایی یا بالینی موفق را در زنان </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">با و بدون </span></span><span dir="LTR" style="font-size:10.0pt">OHSS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">پس از </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">، پیش&shy;بینی کنند.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری: </span></span></b><span dir="LTR" style="font-size:10.0pt">OHSS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">ممکن است بر پیامد مرتبط با </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در بیماران </span></span><span dir="LTR" style="font-size:10.0pt">PCOS</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تأثیری نداشته باشد. نتیجه اشاره شده ممکن است توسط مقادیر هورمون&shy;های جنسی نیز تعیین نشود.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Background:</b> Ovarian hyperstimulation syndrome (OHSS) as a known complication in women with polycystic ovarian syndrome (PCOS) may occur following inducible fertility treatments such as in vitro fertilization (IVF) and can affect the sequels of these treatments.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Objective:</b> This study aimed to assess the effects of OHSS on pregnancy outcomes through IVF in women with PCOS. Also, we assessed the value of baseline sexual hormones to predict the pregnancy&#39;s success.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Materials and Methods:</b> This case-control study was conducted on 180 consecutive women suffering from PCOS who were candidates for IVF at Fatemieh hospital in Hamadan, Iran, from May-July 2022. The women were assigned to the case group (with OHSS, n = 129) and the control group (without OHSS, n = 51). Measuring the sexual hormones was performed using the enzyme-linked immunosorbent technique.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Results:</b> In the multivariable logistic regression model, OHSS could not predict the likelihood of clinical or chemical pregnancy following IVF. None of the baseline sexual hormones could predict the successful chemical or clinical pregnancy in PCOS women following IVF.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> OHSS may not influence IVF-related outcomes in PCOS women. The values of sexual hormones may not also determine the pointed outcome.</span></span></span></div> سندرم تحریک بیش از حد تخمدان, لقاح, سندرم تخمدان پلی کیستیک. Ovarian hyperstimulation syndrome, Fertilization, Polycystic ovary syndrome. 921 928 http://ijrm.ir/browse.php?a_code=A-10-2453-1&slc_lang=en&sid=1 Shamim Pilehvari Sh.pilehvar@yahoo.com 0000-0002-2639-2941 No Clinical Research Development Unit of Fatemieh Hospital, Department of Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran. Nahid Radnia 0000-0003-3720-1319 No Clinical Research Development Unit of Fatemieh Hospital, Department of Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran. Somayeh Ahmadiani snor.ahmadiani@yahoo.com 0000-0003-4077-4054 No Clinical Research Development Unit of Fatemieh Hospital, Department of Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran. Elaheh Talebi-Ghane talebi_ghane@yahoo.com 0000-0003-2610-1419 No Modeling of Non-Communicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Neda Alimohammadi Nalimohamadi68@yahoo.com 0000-0001-7823-5473 No Clinical Research Development Unit of Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran. Zahra Mousaei Tokaldani dr.mousaei1366@gmail.com 0000-0001-6902-3003 Yes Clinical Research Development Unit of Fatemieh Hospital, Department of Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran.