en میزان نسفاتین-1 در گردش خون زنان مبتلا به سندرم تخمدان پلی کیستیک: یک مرور سیستماتیک و متاآنالیز Reproductive Endocrinology Review article Review Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">مقدمه: </span></b><span b="" lang="FA" mitra="" style="font-family:">سندرم تخمدان پلی&shy;کیستیک (</span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span><span b="" lang="FA" mitra="" style="font-family:">) یک اختلال غدد درون&shy;ریز شایع در جمعیت زنان است. </span><span lang="FA" style="font-size:10.0pt"><span b="" mitra="" style="font-family:">نسفاتین-1 </span></span><span b="" lang="FA" mitra="" style="font-family:">یک نوروپپتید سنتز شده در هیپوتالاموس و سایر اندام&shy;های محیطی است و همچنین نظرات متناقضی در مورد ارتباط آن با </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span> <span b="" lang="FA" mitra="" style="font-family:">وجود دارد.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">هدف: </span></b><span b="" lang="FA" mitra="" style="font-family:">هدف از این مطالعه بررسی ارتباط بین نسفاتین-1 و کاربرد بالقوه آن به عنوان یک نشانگر زیستی برای شناسایی </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span><span b="" mitra="" style="font-family:"> بود.</span><b><span dir="LTR" style="font-family:"Arial","sans-serif""></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">مواد و روش&shy; ها: </span></b><span b="" lang="FA" mitra="" style="font-family:">یک مرور سیستماتیک و متاآنالیز برای شناسایی مقالات مرتبط از پایگاه‌های اطلاعاتی مانند </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PubMed</span></span><span b="" lang="FA" mitra="" style="font-family:">، </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Web of Science</span></span><span b="" lang="FA" mitra="" style="font-family:">، </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Cochrane</span></span><span b="" lang="FA" mitra="" style="font-family:">، </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">EMBASE</span></span><span b="" lang="FA" mitra="" style="font-family:">، </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Scopus</span></span><span b="" mitra="" style="font-family:"> و </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Google Scholar</span></span><span b="" mitra="" style="font-family:"> انجام شد. تفاوت میانگین استاندارد شده (</span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SMD</span></span><span b="" lang="FA" mitra="" style="font-family:">) و فاصله اطمینان 95% با استفاده از مدل اثرات تصادفی برای مقایسه نتایج در بین گروه&shy;ها محاسبه شد. علاوه بر این، متارگرسیون و تجزیه و تحلیل زیر گروهی برای روشن کردن منابع ناهمگنی انجام شد.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">نتایج: </span></b><span b="" lang="FA" mitra="" style="font-family:">متاآنالیز شامل 12 مطالعه با 1222 شرکت‌کننده بود و یافته‌ها رابطه معناداری بین </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span><span b="" mitra="" style="font-family:"> و سطح نسفاتین-1 را نشان دادند. تفاوت میانگین استاندارد شده تلفیقی (04/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span b="" lang="FA" mitra="" style="font-family:">، 07/1-00/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">CI</span></span><span b="" mitra="" style="font-family:"> 95%، 54/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SMD</span></span><span b="" lang="FA" mitra="" style="font-family:">) تفاوت معنی&shy;داری را بین گروه&shy;های ارزیابی شده نشان داد. علاوه بر این، تجزیه و تحلیل زیرگروهی نشان داد که تفاوت قابل‌ توجهی در سطوح نسفاتین-1 در بین زنان مبتلا به </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span> <span b="" lang="FA" mitra="" style="font-family:">و همراه با مدل هموستاتیک نسبت مقاومت به انسولین بالا وجود دارد&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; (001/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">> </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span b="" lang="FA" mitra="" style="font-family:">، 00/2-92/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">CI</span></span><span b="" lang="FA" mitra="" style="font-family:"> 95%، 46/1 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SMD</span></span><span b="" lang="FA" mitra="" style="font-family:">).</span><b><span dir="LTR" style="font-family:"Arial","sans-serif""></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">نتیجه &shy;گیری: </span></b><span b="" lang="FA" mitra="" style="font-family:">این متاآنالیز ارتباط بین سطوح بالای نسفاتین-1 و </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span> <span b="" lang="FA" mitra="" style="font-family:">را شناسایی می‌کند و نقش بالقوه نسفاتین-1 را در ایجاد </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PCOS</span></span> <span b="" lang="FA" mitra="" style="font-family:">نشان می‌دهد و آن را به عنوان یک نشانگر زیستی تشخیصی بالقوه برای بیماری پیشنهاد می‌کند. با این حال، تحقیقات بیشتر برای تأیید این یافته&shy;ها ضروری است.</span><b><span dir="LTR" style="font-family:"Arial","sans-serif""></span></b></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:12pt"><b>Background:</b> Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-1 is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS.</span><br> <span style="font-size:12pt"><b>Objective:</b> This study aims to investigate the correlation between nesfatin-1 and PCOS and evaluates the effectiveness of nesfatin-1 as a biomarker for the detection of PCOS in women.</span><br> <span style="font-size:12pt"><b>Materials and Methods:</b> A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science<a name="_Hlk148020094">, Cochrane, EMBASE</a>, Scopus, and Google Scholar. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity.</span><br> <span style="font-size:12pt"><b>Results:</b> The meta-analysis involved 12 studies with 1222 participants, and the findings revealed a significant relationship between PCOS and nesfatin-1 levels. The pooled (SMD = 0.54; 95% CI: 0.00-1.07; p = 0.04) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-1 levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 1.46; 95% CI: 0.92-2.00; p < 0.001).</span><br> <span style="font-size:12pt"><b>Conclusion:</b> Our meta-analysis indicates an association between high nesfatin-1 levels and PCOS. This suggests a potential role of nesfatin-1 in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.</span></span></div> سندرم تخمدان پلی­کیستیک, مقاومت به انسولین, شاخص توده بدنی, متاآنالیز. Polycystic ovary syndrome, Insulin resistance, Body mass index, Meta-analysis. 777 788 http://ijrm.ir/browse.php?a_code=A-10-765-3&slc_lang=en&sid=1 Seyed Sobhan Bahreiny bahreiny.s@ajums.ac.ir 0000-0003-2148-1205 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Akram Ahangarpour akramahangarpour@gmail.com 0000-0002-9534-9699 Yes Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Ali Asghar Hemmati hemmati_aa@yahoo.com 0000-0003-2085-8437 No Marine Pharmaceutical Research Center, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran . Razieh Kazemzadeh kazemzadehrazieh@gmail.com 0000-0002-4188-8400 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad-Navid Bastani navid.bastani2@gmail.com 0000-0003-4858-8723 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Mohammad Reza Dabbagh Dabbagh200@gmail.com 0000-0001-8771-0846 No Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Mojtaba Aghaei Mojtabaaghaei745@gmail.com 0000-0002-6382-6657 No Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.