en ارزیابی اثر خراش آندومتر با قیچی هیستروسکوپی بر پیامدهای انتقال جنین منجمد: یک مطالعه ی کوهورت تاریخی Assisted Reproductive Technologies Original Article Original Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">مقدمه:</span></b><span b="" lang="FA" mitra="" style="font-family:"> خراش آندومتر (</span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">ES</span></span><span b="" lang="FA" mitra="" style="font-family:">) به عنوان راهی برای بهبود میزان موفقیت روش&shy;های کمک&shy;باروری با بررسی شکست لانه&shy;گزینی پیشنهاد شده است.</span><span dir="LTR" style="font-family:"Arial","sans-serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">هدف:</span></b><span b="" lang="FA" mitra="" style="font-family:"> در این مطالعه، تأثیر </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">ES</span></span><span b="" mitra="" style="font-family:"> را بر پیامدهای انتقال جنین منجمد (</span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FET</span></span><span b="" lang="FA" mitra="" style="font-family:">) در بیمارانی که حداقل دو چرخه انتقال جنین ناموفق داشتند، ارزیابی گردید.</span><span dir="LTR" style="font-family:"Arial","sans-serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">مواد و روش &shy;ها:</span></b><span b="" lang="FA" mitra="" style="font-family:"> در این کوهورت تاریخی، داده&shy;های 236 زن نابارور که از ژانویه 2015 تا دسامبر 2021 در مرکز ناباروری ابن&shy;سینا، تهران، ایران تحت </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FET</span></span> <span b="" lang="FA" mitra="" style="font-family:">قرار گرفته بودند جمع&shy;آوری شد. بر اساس داشتن </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">ES</span></span><span b="" lang="FA" mitra="" style="font-family:"> قبل از </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FET</span></span><span b="" lang="FA" mitra="" style="font-family:">، شرکت&shy;کنندگان به دو گروه خراش (118 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">n</span></span><span b="" lang="FA" mitra="" style="font-family:">)، یا بدون خراش (118 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">n</span></span><span b="" lang="FA" mitra="" style="font-family:">) تقسیم شدند. میزان بارداری و نتایج حاملگی بین گروه&shy;ها با هم مقایسه شد.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">نتایج:</span></b><span b="" lang="FA" mitra="" style="font-family:"> بیماران هر دو گروه از نظر وزن، میانگین توده بدنی، تعداد جنین‌های قبلی، مدت زمان ناباروری و مشخصات دموگرافیک مشابه بودند. با این حال، گروه خراش میانگین سنی کمی بالاتر داشت (31/32 در مقابل 96/29 سال، 001/0 </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p <</span></span><span b="" lang="FA" mitra="" style="font-family:">). تفاوت آماری معنی&shy;داری بین گروه&shy;ها از نظر میزان بارداری مشاهده نشد (89/0 </span><span lang="FA" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">= </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span b="" lang="FA" mitra="" style="font-family:">). مدل رگرسیون لجستیک هیچ ارتباط معنی‌داری بین خراش، مدت زمان ناباروری و تعداد تلاش‌های قبلی </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FET</span></span> <span b="" lang="FA" mitra="" style="font-family:">و احتمال بارداری نشان نداد. هیچ عارضه مهمی مشاهده نشد.</span><span dir="LTR" style="font-family:"Arial","sans-serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span b="" lang="FA" mitra="" style="font-family:">نتیجه‌گیری:</span></b><span b="" lang="FA" mitra="" style="font-family:"> خراش هیستروسکوپی آندومتر با قیچی احتمالاً تأثیری بر پیامدهای </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FET</span></span><span b="" mitra="" style="font-family:"> از جمله بارداری یا میزان تولد زنده ندارد.</span><span dir="LTR" style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><b><span style="font-size:12.0pt">Background:</span></b><span style="font-size:12.0pt"> Endometrial scratch (ES) has been suggested to improve assisted reproductive techniques success rates by investigating implantation failure. </span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><b><span style="font-size:12.0pt">Objective:</span></b><span style="font-size:12.0pt"> In this study, we evaluated the effect of ES on the outcomes of frozen embryo transfer (FET) in women with at least 2 failed embryo transfer cycles.</span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><b><span style="font-size:12.0pt">Materials and Methods:</span></b> <span style="font-size:12.0pt">In this historical cohort study, medical data of 236 infertile women who underwent in-vitro fertilization-FET at</span><span style="font-size:12.0pt"> Ebne-sina Infertility Center, Tehran, Iran, from January 2015-December 2021 was extracted from their medical records</span><span style="font-size:12.0pt">. Based on having ES before FET, they were assigned to either the scratch (n = 118) or the no-scratch group (n = 118). We compared these groups regarding pregnancy rates and outcomes.</span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><b><span style="font-size:12.0pt">Results: </span></b><span style="font-size:12.0pt">The demographic characteristics were similar in both groups regarding weight, body mass index, the number of previous embryo transfers, and the duration of infertility. However, the scratch group had a slightly higher mean age (32.31 vs. 29.96 yr, p < 0.001). No statistically significant difference was observed between groups regarding pregnancy rate (p = 0.89). No significant association was observed between scratch, infertility duration, the number of previous FET attempts, and the likelihood of pregnancy in a logistic regression model. No major</span><span style="font-size:12.0pt"> complications were observed</span><span style="font-size:12.0pt">.</span></span></span></span><br> <span style="font-size:10pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><b><span style="font-size:12.0pt">Conclusion: </span></b><span style="font-size:12.0pt">Hysteroscopic endometrial scratching with scissors probably has no effect on FET outcomes, including pregnancy or live birth rates. </span></span></span></span></span></div> کلمات کلیدی: هیستروسکوپی, ناباروری, میزان بارداری, تولد زنده. Hysteroscopy, Infertility, Pregnancy rate, Live birth. 737 744 http://ijrm.ir/browse.php?a_code=A-10-2532-1&slc_lang=en&sid=1 Sara Saedi drsarasaedi@gmail.com 0009-0009-1246-1887 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Amirhossein Tayebi amirhossein.tayebi.md@gmail.com 0000-0002-6327-7125 No Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran. Maedeh Ghorbani Kahrizsangi Maedeh.ghorbani.0305@gmail.com 0009-0008-0608-1418 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Fatemeh Jalalinezhad nejali861@gmail.com 0009-0008-8149-5418 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Aryan Ayati aryanayati@gmail.com 0000-0002-0241-6865 No Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Alireza Hadizadeh ali1375hadi@gmail.com 0000-0003-0821-7557 No Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Bita Badehnoosh b_badehnoosh@yahoo.com 0000-0001-8469-8378 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Atousa Karimi a75karimi@gmail.com 0000-0002-0389-0577 Yes Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.