en کارآیی صدمه موضعی اندومتر در بیمارانی که قبلا نتیجه IVF-ICSI آن ها ناموفق بوده است Original Article Original Article <strong><span style="font-family:b mitra;">مقدمه:</span></strong><span style="font-family:b mitra;"> آخرین مطالعات نشان داده است که صدمه موضعی اندومتر یک روش مفید در بهبود موفقیت نتایج </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">IVF-ICSI</span></span></span> <span style="font-family:b mitra;">است.</span><br> <strong><span style="font-family:b mitra;">هدف: آ</span></strong><span style="font-family:b mitra;">یا صدمه موضعی آندومتر به وسیله </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">pipelle</span></span></span><span style="font-family:b mitra;"><span style="font-size:10.0pt;">،</span></span><span style="font-family:b mitra;"> می&shy;تواند باعث بهبود میزان لانه&shy; گزینی، </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">cleavage rate</span></span></span><span style="font-family:b mitra;">، و نتیجه حاملگی در بیماران تحت درمان </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">IVF-ICSI</span></span></span><span style="font-family:b mitra;"> با سابقه </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">IVF failure</span></span></span><span style="font-family:b mitra;"> شود؟</span><br> <strong><span style="font-family:b mitra;">مواد و روش &shy;ها: </span></strong><span style="font-family:b mitra;">در این مطالعه مقطعی گذشته نگر یک بیوپسی اندومتر در روز 21 درمان در 41 بیمار انجام شد. گروه کنترل را 42 زن تشکیل دادند. </span><br> <strong><span style="font-family:b mitra;">نتایج: </span></strong><span style="font-family:b mitra;">شیوع لانه&shy; گزینی در گروه مداخله 22/5% و در گروه کنترل 10/5% بود. اختلاف این دو از نظر آماری معنی&shy; دار بود (0/01=</span><span dir="LTR"><span style="font-family:times new roman,serif;">p</span></span><span style="font-family:b mitra;">). درصد حاملگی در گروه مداخله 43/9% و در گروه کنترل 21/4% بود (0/03=</span><span dir="LTR"><span style="font-family:times new roman,serif;">p</span></span><span style="font-family:b mitra;">). </span><br> <strong><span style="font-family:b mitra;">نتیجه&shy; گیری: </span></strong><span style="font-family:b mitra;">صدمه موضعی آندومتر در سیکلی که انتقال جنین ضورت نمی&shy; گیرد می&shy;تواند منجر به بهبود درصد لانه&shy; گزینی و حاملگی در سیکل </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">IVF-ICSI</span></span></span><span style="font-family:b mitra;">&nbsp;&nbsp; بعدی در بیماران با سابقه شکست </span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:10.0pt;">IVF</span></span></span><span style="font-family:b mitra;"> شود. </span> <strong>Background:</strong> The latest studies reported that local endometrial injury is a useful method to improve the success of IVF-ICSI outcome.<br> <strong>Objective: </strong>To assess whether local endometrial injury occurred by Pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent IVF-ICSI cycle in patients who had recurrent IVF failure.<br> <strong>Materials and Methods:</strong> An endometrial biopsy was performed on day 21st in 41 patients as intervention group in this retrospective cross-sectional study. The control group contained 42 women.<br> <strong>Results: </strong>Implantation rate was 22.5% and 10.5% in intervention and control group, respectively and this difference was found to be statistically significant (p=001). Pregnancy rate was 43.9% in the intervention group and this parameter was significantly lower in control group (21.4%) (p=0.03).<br> <strong>Conclusion:</strong> Local endometrial injury in the nontransfer cycle increases the implantation rate and pregnancy rate in the subsequent IVF-ICSI cycle in patients who had previous failed IVF-ICSI outcome. آندومتر, In vitro fertilization, انتقال جنین, حاملگی Local endometrial injury, In vitro fertilization, Embryo transfer, Pregnancy 567 570 http://ijrm.ir/browse.php?a_code=A-10-549-23&slc_lang=en&sid=1 Mustafa Kara mustafa.kara@bozok.edu.tr Yes Department of Obstetrics and Gynecology, Bozok University, Medical Faculty, Yozgat, Turkey Turgut Aydin No Department of Obstetrics and Gynecology, Kayseri In vitro Fertilization Center, Kayseri, Turkey Nurettin Turktekin No Department of Obstetrics and Gynecology, Kayseri In vitro Fertilization Center, Kayseri, Turkey Karacavus S No Department of Nuclear Medicine, Bozok University Medical Faculty, Yozgat, Turkey