International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1402
8
1
gregorian
2023
11
1
21
11
online
1
fulltext
en
مقایسه شاخصهای سونوگرافی داپلر شریان رحمی و خون زیر آندومتر در زنان کاندید انتقال جنین منجمد با و بدون شکست مکرر لانهگزینی در روز شروع پروژسترون: یک مطالعه مقطعی
Comparison of Doppler ultrasound indices of uterine artery and sub endometrial blood supply in frozen embryo transfer with and without repeated implantation failure: A cross-sectional study
Assisted Reproductive Technologies
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">خون­رسانی رحم به عنوان یک عامل بالقوه در شکست لانه­گزینی شناخته شده است.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف از این مطالعه بررسی شاخص­های داپلر در شریان رحمی شامل جریان و مقاومت عروقی و همچنین میزان خون­رسانی زیر آندومتر در زنان با سابقه شکست مکرر لانه­گزینی در مقایسه با گروه بدون شکست مکرر می­باشد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش­ ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه مقطعی بر روی 139 زن کاندید انتقال جنین منجمد که به پژوهشکده علوم تولید­مثل یزد از بهمن 1401 تا تیر 1402 مراجعه کرده بودند انجام شد. گروه الف (68 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) شامل زنان با دو بار سابقه شکست در لانه­گزینی و گروه ب (71 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">n</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) زنانی بودند که در نوبت اول کاشت و یا بدون شکست قبلی بوده­اند. شاخص­های سونوگرافی داپلر در شریان رحمی و خون­رسانی ساب آندومتر که در هر دو گروه اندازه­گیری شده است شامل میزان خون­رسانی ساب آندومتر</span></span><span lang="FA" style="font-size:11.0pt">-</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">جریان خون شریان رحمی</span></span><span lang="FA" style="font-size:11.0pt">-</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">میزان مقاومت شریان رحمی و همچنین حداکثر سرعت سیستولی شریان رحمی است.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">از نظر آماری بین حداکثر سرعت سیستولی و میزان جریان خون در هر دو گروه اختلاف معنی­داری وجود نداشت. اما در میزان مقاومت شریان رحمی تفاوت معنی­داری وجود داشت به این صورت که در گروه الف مقاومت بیشتر بود (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">). در میزان خونرسانی ساب آندومتر هم تفاوت معنی­داری وجود داشت به این شکل که در گروه الف خونرسانی کمتر بود (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">).</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مطالعه ما نشان داد که در گروه الف میزان مقاوت در شریان رحمی بالاتر است.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Background: </span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Uterine blood supply has been identified as a potential factor in implantation failure. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Objective:</span></span></b> <span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">This study aimed to investigate Doppler indices in the uterine artery, including vascular flow and resistance, as well as the amount of sub-endometrial blood supply in women with a history of repeated implantation failure (RIF) compared to the non</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">-</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">RIF group.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Materials and Methods:</span></span></b> <span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">This</span></span> <span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">cross-sectional study was conducted with 139 women candidates for frozen embryo transfer</span></span><span lang="EN" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> in Yazd Reproductive Sciences Institute, Yazd, Iran from February to July 2023</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">. Group A (n = 68) included women with a history of more than 2 RIF, and group B (n = 71) included women candidates for implantation for the first time without RIF. Doppler ultrasound indices of uterine artery and sub-endometrium, including sub-endometrial flow, uterine artery flow, uterine artery resistance, and peak systolic velocity, were recorded.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Results:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> No significant differences were observed in uterine artery Doppler pulsatility index and peak systolic velocity between groups, but the uterine artery resistance index was significantly higher in the A group (p < 0.001). A significant difference was observed in the perfusion area between groups. 60/68 women in the group A had endometrial perfusion in areas 2 and 3 (p < 0.001).</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Conclusion:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> Our study revealed that women with RIF exhibited higher resistance index in sub-endometrial arteries compared to the non-RIF group.</span></span></span></span></span></div>
سونوگرافی داپلر, انتقال جنین منجمد, شکست لانهگزینی مکرر.
Doppler ultrasound,embryo transfer, implantation failure
937
942
http://ijrm.ir/browse.php?a_code=A-10-226-10&slc_lang=en&sid=1
Fatemeh
Bayati
drfb2941@gmail.com