en آیا شاخص توده بدنی بر نتایج سیکل های لقاح آزمایشگاهی تأثیر می‌گذارد؟ مطالعه مقطعی گذشته‌نگر Assisted Reproductive Technologies Original Article Original Article <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">افراد دارای اضافه وزن و چاق با مشکلات سلامتی متعددی روبرو هستند. نشان داده شده است که چاقی زنان منجر به کاهش باروری در جمعیت عمومی می&shy;شود. نتایج فناوری کمک&shy;باروری در بیماران چاق به طور گسترده مورد مطالعه قرار گرفته است، اما نتایج قطعی نیست.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">هدف از این مطالعه مقایسه میزان تولد زنده در زنان با 4 نوع </span></span><span dir="LTR" style="font-size:10.0pt">BMI</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مختلف بود.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">در این مطالعه مقطعی، داده‌های 1611 زن کاندید چرخه‌های انتقال جنین تازه و منجمد از مجموع 2051 پرونده پزشکی در مؤسسه علوم باروری یزد از اردیبهشت 1398 تا اردیبهشت 1400 استخراج شد. شرکت&shy;کنندگان بر اساس شاخص توده بدنی (</span></span><span dir="LTR" style="font-size:10.0pt">BMI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) به 4 گروه (کم وزن، وزن طبیعی، اضافه وزن و چاق) تقسیم شدند و نرخ تولد زنده (</span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) به عنوان پیامد اصلی در نظر گرفته شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">از این 1611 زن، 39 زن کم وزن، 585 زن طبیعی، 676 نفر اضافه وزن و 311 زن چاق بودند. زنان کم وزن کمترین میزان تولد (8/12%) را داشتند اما از نظر آماری تفاوت معنی&shy;داری وجود نداشت (55/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">). علاوه بر این، </span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> در چهار گروه </span></span><span dir="LTR" style="font-size:10.0pt">BMI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> بر اساس سن، نوع چرخه انتقال (تازه یا منجمد) و علت ناباروری مقایسه شد و </span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> در چهار گروه </span></span><span dir="LTR" style="font-size:10.0pt">BMI</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"> قابل مقایسه بود. با این حال، میزان تخمک متافاز 2 (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، دوز مصرف گنادوتروپین در چرخه &nbsp;(001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">)، و سطح استرادیول (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">) تفاوت آماری معنی‌داری داشتند.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجه &shy;گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">با توجه به مطالعه ما، چاقی بدون توجه به چرخه‌های انتقال جنین تازه یا منجمد، گروه‌های سنی مختلف و علل ناباروری بر میزان تولد در چرخه </span></span><span dir="LTR" style="font-size:10.0pt">IVF</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">تأثیری ندارد</span></span><span dir="LTR" style="font-size:11.0pt"><span arial="" style="font-family:">.</span></span></span></span></span></span></span><br> &nbsp; <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Overweight and obese people face several health problems. Female obesity has been shown to reduce fertility in the general population. Assisted reproductive technology outcomes in obese cases are widely studied, but the results are inconclusive.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This study aimed</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> to compare live birth rate (LBR) among women with 4 different types of </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">body mass index (</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">BMI).</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> In this cross-sectional study, data of 1611 women, </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">who were candidates for fresh and frozen embryo transfer cycles,</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> was extracted from 2051 medical files</span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> at the Reproductive Sciences Institute, Yazd, Iran from May 2019-May 2021. The participants were divided into 4 groups (underweight, normal, overweight, and obese) according to their BMI, and LBR was considered to be the main outcome. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Of 1611 women, 39 were underweight, 585 were normal, 676 were overweight, and 311 were obese. Underweight women had the lowest LBR (12.8%), but there was no statistically significant difference (p = 0.55). In addition, LBR was compared in the 4 BMI groups according to age, type of transfer cycle (fresh or freeze), and cause of infertility, and there was comparable LBR in the 4 BMI groups. However, metaphase 2 oocyte rate, doses of gonadotropin usage in the cycles, and estradiol level had statistically significant differences (p < 0.001).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> According to our study, obesity does not affect LBR in the IVF cycle, regardless of fresh or frozen embryo transfer cycles, different age groups, and causes of infertility.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></div> شاخص توده بدنی, فناوری کمک باروری, نتایج حاملگی, میزان تولد زنده, سن. Body mass index, Assisted reproductive technique, Pregnancy outcome, Live birth rate, Age. 1021 1030 http://ijrm.ir/browse.php?a_code=A-10-624-5&slc_lang=en&sid=1 Fereshteh Bahrami fereshtehbahrami1966@gmail.com 0000-0002-8663-7234 No Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Saeideh Dashti saeideh_dashti@yahoo.com 0000-0001-7089-0772 Yes Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Esmat Mangoli es.mangoli@gmail.com 0000-0001-6206-7831 No Department of Reproductive Biology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Hanie sadat Hosseini hanii.hosseini98@gmail.com 0000-0002-7844-8249 No Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.