en تأثیر شیاف واژینال حنا همراه با آنتی بیوتیک درمانی در درمان سرویسیت: یک کارآزمایی بالینی تصادفی‌سازی شده Fertility & Infertility Original Article Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">سرویسیت یک بیماری شایع زنانه است که معمولاً به درمان‌های رایج پاسخ نمی‌دهد. سرویسیت طولانی مدت می‌تواند منجر به مشکلات جدی سلامت مانند التهاب، ناباروری و سرطان شود. روغن حنا که یک فرآورده گیاهی در طب ایرانی است برای بیماری‌های مرتبط با رحم مانند سرویسیت توصیه می‌شود.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">هدف:</span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;"> این مطالعه با هدف بررسی اثربخشی روغن حنا به صورت شیاف واژینال در ترکیب با آنتی&shy;بیوتیک‌ درمانی در درمان سرویسیت انجام شد. </span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">مواد و روش&shy; ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">این کارآزمایی بالینی تصادفی‌سازی شده با دارونما بر روی 92 زن غیر یائسه مبتلا به سرویسیت در درمانگاه بقایی‌پور بیمارستان شهید صدوقی یزد و درمانگاه طب ایرانی اردکان، یزد، انجام شد. شرکت&shy;کنندگان به دو گروه مداخله با شیاف واژینال روغن حنا و گروه دارونما (46 نفر در هر گروه) تقسیم شدند. در طول مطالعه، درمان آنتی&shy;بیوتیکی برای هر دو گروه انجام شد. علائم سرویسیت بین گروه&shy;ها و درون هر گروه مقایسه شد.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">از 92 نفری که واجد شرایط ورود به مطالعه بودند در نهایت 41 نفر از هر گروه مطالعه را تکمیل کردند. نتایج نشان داد که، در مقایسه با دارونما، شیاف روغن حنا سبب بهبود قابل توجهی در برخی پارامترها از جمله ترشحات واژن (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">)، اندازه زخم دهانه رحم (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">)، درد حین مقاربت (046/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">) و خونریزی پس از مقاربت (001/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">) شد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">نتیجه&shy; گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:&quot;B Mitra&quot;">یافته&shy;ها حاکی از آن است که شیاف واژینال روغن حنا می&shy;تواند بدون توجه به پاتولوژی آن در درمان علائم بالینی سرویسیت مؤثر باشد.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"></span></span></b></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:12.0pt">Background:</span></b><span style="font-size:12.0pt"> Cervicitis is a prevalent gynecologic disease, which does not usually respond to conventional treatments. Long-term cervicitis can cause serious health problems such as inflammation, infertility, and cancer. Henna oil, an herbal product in Persian medicine, is recommended for uterine diseases like cervicitis.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:12.0pt">Objective:</span></b><span style="font-size:12.0pt"> This study aims to evaluate the efficacy of Henna oil as a vaginal suppository in combination with an antibiotic regimen in the treatment of cervicitis. </span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:12.0pt">Materials and Methods:</span></b><span style="font-size:12.0pt"> This randomized placebo-controlled trial, included 92 non-menopausal women with cervicitis at the Baqaipur Clinic of Shahid Sadoughi hospital in Yazd and the Persian Medicine Health Center in Ardakan, Yazd, Iran. Participants were further divided into either the Henna oil vaginal suppository group or the placebo group (n = 46/each group). During the study, the antibiotic treatment was administered to both groups. Cervicitis symptoms were compared between the groups and within each group. </span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:12.0pt">Results: </span></b><span style="font-size:12.0pt">Of 92 included individuals, 41 in each group completed the study. Results revealed that significant differences were observed in some outcomes, including vaginal discharge (p < 0.001), cervical ulcer size (p < 0.001), dyspareunia (p = 0.046), and postcoital bleeding (p < 0.001), indicating that the treatment was more effective in the henna group compared to the placebo group.</span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:12.0pt">Conclusion:</span></b><span style="font-size:12.0pt"> Findings supported that the vaginal suppository of Henna oil in combination with antibiotic therapy could be effective in the improvement of clinical symptoms of cervicitis regardless of its pathology.</span></span></span></span></div> حنا, طب سنتی ایرانی, سرویسیت, ناباروری, شیاف واژینال, کارآزمایی بالینی. Lawsonia inermis, Persian+traditional medicine, Uterine cervicitis, Infertility, Vaginal suppository, Clinical trial. 269 282 http://ijrm.ir/browse.php?a_code=A-10-2658-1&slc_lang=en&sid=1 Naeemeh Nabimeybodi drnabimeybodi@gmail.com 0000-0002-0251-502x No Department of Persian Medicine, School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran. Fahimeh Nokhostin fahimeh.nokhostin@yahoo.com 0000-0003-1936-5635 No Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Rahele Zareshahi rahele.zareshahi@gmail.com 0000-0002-3577-8037 No Department of Pharmacognosy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Traditional Pharmacy and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Kamalinejad mkamalinejad@yahoo.com 0000-0002-5946-4913 No School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hedayat Akhundimeybodi hamaybodi@yahoo.com 0009-0008-0092-1594 No Department of Urology, School of Medicine, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran. Farzan Madadizadeh madadizadehfarzan@gmail.com 0000-0002-5757-182X No Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohsen Nabi Meybodi nabimaibodi@yahoo.com 0000-0002-9247-2325 No Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Narges Seifi Mazraeno Nargesseyfi77@gmail.com 0009-0008-2450-578x No Department of Midwifery, Islamic Azad University, Meybod Branch, Yazd, Iran. Razieh Nabimeybodi r.nabimeybodi@gmail.com 0000-0003-1221-4260 Yes Department of Persian Medicine, School of Persian Medicine, Shahid Sadoughi University of Medical Sciences, Ardakan, Yazd, Iran.