International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1404
2
1
gregorian
2025
5
1
23
5
online
1
fulltext
en
سندرم متابولیک در سنین باروری: یک مطالعه مقطعی
Metabolic syndrome in reproductive age: A cross-sectional study
Reproductive Physiology
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">چاقی بیش از حد و سندرم متابولیک (</span></span><span dir="LTR" style="font-size:10.0pt">MetS</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)، به عنوان نتایج وزن اضافی بدن، به سطح اپیدمی جهانی رسیدهاند.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه با هدف بررسی ویژگیهای دوره سندرم متابولیک در مردان و زنان در سنین باروری انجام شد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش ­ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه مقطعی بر روی ۱۴۰ مراجع با سن بین 49</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial",sans-serif">-</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">35 سال در پلیکلینیکهای شهری شماره ۱، ۳ و ۴، آکتوب، قزاقستان از مارس ۲۰۱۶ تا ۲۰۱۹ انجام شد. مراجعین بر اساس تشخیص سندرم متابولیک به ۲ زیرگروه تقسیم شدند. گروه مورد (با سندرم متابولیک) و گروه کنترل (بدون سندرم متابولیک) (۷۰ نفر/هر کدام شامل ۴۰ زن و ۳۰ مرد). از روشهای آنتروپومتریک، ابزاری و آزمایشگاهی برای تأیید تشخیص سندرم متابولیک و تعیین ویژگیهای آن در هر دو گروه استفاده شد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman",serif"><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج نشان­دهنده افزایش سطح اسید اوریک به میزان </span></span><span dir="LTR" style="font-size:10.0pt">μ</span><span dir="LTR" style="font-size:10.0pt">mol/L</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 37/66 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 00/431 و </span></span><span dir="LTR" style="font-size:10.0pt">mol/day</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 90/0 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 47/5 در ادرار بود. اختلال چربی خون در گروه مورد با سطح لیپوپروتئین با چگالی بالا </span></span><span dir="LTR" style="font-size:10.0pt">mmol/L</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 27/0 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 22/1 در مقابل </span></span><span dir="LTR" style="font-size:10.0pt">mmol/L</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 47/0 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 32/1 در گروه کنترل مشاهده شد. سطح تستوسترون در گروه مورد </span></span><span dir="LTR" style="font-size:10.0pt">nmol/L</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 04/3 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 4/16 و در گروه کنترل </span></span><span dir="LTR" style="font-size:10.0pt">nmol/L</span><span style="font-size:11.0pt"><span style="font-family:"B Mitra""> 6/5 </span></span><span lang="FA" style="font-size:10.0pt">±</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> 3/20 بود. تفاوت در سطح تستوسترون از نظر آماری معنی دار بود (01/0 </span></span><span lang="FA" style="font-size:10.0pt">> </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">).</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial",sans-serif"></span></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری: </span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">تجزیه و تحلیل سطح هورمون­های جنسی هیچ روند پایداری را که بتوان آن را به عنوان مارکر تشخیصی در نظر گرفت، نشان نداد. این ممکن است نشاندهندهی همبستگی با ویژگیهای سن باروری افراد مورد بررسی (زن و مرد) باشد. تفاوتهای معنیداری بین سطح هورمونها در گروههای مورد و شاهد مشاهده شد.</span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Obesity and metabolic syndrome (MetS), as components of excess body weight, have reached global epidemic levels. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The study aimed to investigate the features of the MetS course in men and women of reproductive age.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This cross-sectional study was conducted with 140 participants aged between 35 and 49 yr at City Polyclinics No. 1, 3, and 4, Aktobe, Kazakhstan from March 2016-2019. Participants were divided into 2 subgroups based on diagnosis of MetS. The case group (with MetS), and the control group (without MetS) (n = 70/each consisted of 40 women and 30 men). Anthropometric, instrumental, and laboratory methods were used to confirm the diagnosis of MetS and determine its features in both groups. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span lang="DE-CH" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The results showed an increase in the uric acid level in the blood to 431.00 ± 66.37 μmol/L and 5.47 ± 0.90 mol/day in the urine. Dyslipidemia was also noted in the case group of individuals with high-density lipoprotein levels of 1.22 ± 0.27 mmol/L vs. 1.32 ± 0.47 mmol/L in the control group. The testosterone level was 16.4 ± 3.04 nmol/L in the case group and 20.3 ± 5.6 nmol/L in the control. The difference in testosterone level was found to be statistically significant (p ˂ 0.01).</span></span></span></span></span><br>
<b><span lang="DE-CH" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span lang="DE-CH" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> The analysis of sex hormone levels did not reveal any stable trends that could be considered diagnostic. That may indicate a correlation with the reproductive age characteristics of the examined individuals (men and women): significant differences between hormone levels were fixed in the case and control groups.</span></span></span></div>
سندرم متابولیک, چاقی شکمی, اختلال چربی خون, مقاومت به انسولین, هورمونهای جنسی.
Metabolic syndrome, Abdominal obesity, Dyslipidemia, Insulin resistance, Sex hormones.
383
396
http://ijrm.ir/browse.php?a_code=A-10-2711-1&slc_lang=en&sid=1
Raisa
Aringazina
omnid@zkgmu.kz