International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1403
8
1
gregorian
2024
11
1
22
11
online
1
fulltext
en
بهبود نتایج تولیدمثلی در انتقال جنین منجمد نسبت به انتقال جنین تازه در زنان مبتلا به اندومتریوما: یک مطالعه کوهورت تاریخی
Improving reproductive outcomes in frozen embryo transfer over fresh embryo transfer in women with endometrioma: A historical cohort study
Fertility & Infertility
Original Article
Original Article
<div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مقدمه: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">اندومتریوما، یکی از تظاهرات شایع اندومتریوز و اغلب نشاندهنده شدت بیماری است. لقاح آزمایشگاهی و انتقال جنین (</span></span><span dir="LTR" style="font-size:10.0pt">ET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) از استراتژیهای کلیدی درمان ناباروری مرتبط با اندومتریوز هستند. با این حال، نوع بهینه </span></span><span dir="LTR" style="font-size:10.0pt">ET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> (منجمد یا تازه) و تأثیر آن بر میزان موفقیت بارداری همچنان مورد بحث است و مطالعات محدودی در این زمینه وجود دارد.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">هدف: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">این مطالعه کوهورت تاریخی با هدف مقایسه پیامدهای باروری و نوزادی بین انتقال جنین تازه (</span></span><span dir="LTR" style="font-size:10.0pt">ET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">) و انتقال جنین منجمد (</span></span><span dir="LTR" style="font-size:10.0pt">FET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)، با تمرکز بر نرخ تولد زنده (</span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">)، بارداری بالینی و میزان لانه</span></span><span dir="LTR" lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">‎</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif"">­</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">گزینی در زنان نابارور مبتلا با اندومتریوما، انجام شد.</span></span><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مواد و روش­ ها: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">در این مطالعه گذشته­نگر، پروندههای پزشکی 289 زن نابارور مبتلا به اندومتریوما که بین سال­های 1395 تا 1400 در پژوهشگاه رویان تهران، تحت درمان لقاح آزمایشگاهی/تزریق داخل سیتوپلاسمی اسپرم قرار گرفته بودند، بررسی شد. در نهایت 200 پرونده که معیارهای تعیینشده را دارا بودند، برای بررسی انتخاب شدند. دادههای استخراجشده بین دو گروه </span></span><span dir="LTR" style="font-size:10.0pt">FET</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">(121 نفر) و </span></span><span dir="LTR" style="font-size:10.0pt">ET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> تازه (79 نفر) مقایسه شد. </span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتایج: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">تفاوت معناداری بین گروهها از نظر ویژگیهای دموگرافیک و اندازه اندومتریوما مشاهده نشد. تنها تفاوت معنادار در نتایج باروری، </span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> بود که برای گروه </span></span><span dir="LTR" style="font-size:10.0pt">FET</span> <span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">برابر 4/36% در مقایسه با 8/22% برای گروه </span></span><span dir="LTR" style="font-size:10.0pt">ET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> تازه بود (04/0 </span></span><span lang="FA" style="font-size:10.0pt">= </span><span dir="LTR" style="font-size:10.0pt">p</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">). تفاوت معناداری در نتایج نوزادی بین گروهها مشاهده نشد. به طور کلی، مطالعه ما نشان میدهد که </span></span><span dir="LTR" style="font-size:10.0pt">FET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> ممکن است به </span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> بالاتری در زنان مبتلا به اندومتریوما منجر شود.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:inter-ideograph"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">نتیجه­ گیری: </span></span></b><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra"">مطالعه ما نشان میدهد که </span></span><span dir="LTR" style="font-size:10.0pt">FET</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> ممکن است به </span></span><span dir="LTR" style="font-size:10.0pt">LBR</span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Mitra""> بالاتری در زنان مبتلا به اندومتریوما منجر شود.</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="font-family:"Arial","sans-serif""></span></span></b></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Background:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> Endometrioma, a common manifestation of endometriosis, often indicates the severity of the disease. In vitro fertilization and embryo transfer (ET) are key therapeutic strategies for infertility associated with endometriosis. However, the optimal type of ET (frozen or fresh) and its impact on pregnancy success rates remain debated, with limited studies available.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Objective:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> <a name="_Hlk178875931">This </a></span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">historical cohort </span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">study aimed to compare fertility and neonatal outcomes, focusing on live birth rate (LBR), clinical pregnancy, and implantation rates in women with endometrioma-associated infertility, between fresh and frozen embryo transfer (FET). </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> In this </span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">historical cohort study</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">, the medical records (files) of 289 women diagnosed with endometrioma-related infertility, who underwent in vitro fertilization/intracytoplasmic sperm injection treatment at Royan Institute, Tehran, Iran between March 2016-2021 were reviewed.</span></span> <span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Ultimately, 200 files that met the established criteria were selected for review. The extracted data was then compared between groups: FET (n = 121) and fresh ET (n = 79).</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Results:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> No significant differences were observed between the groups in terms of demographic characteristics and endometrioma size. The only significant difference in fertility outcomes was the LBR, which was 36.4% for the FET group compared to 22.8% for the fresh ET group (p = 0.04). No significant differences were observed in neonatal outcomes between the groups.</span></span> <span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Overall, our study suggests that FET may lead to higher LBRs in women diagnosed with endometrioma.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif"">Conclusion:</span></span></b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""> Our study suggests that FET may lead to higher LBRs in women diagnosed with endometrioma.</span></span></span></span></span></div>
اندومتریوما, انتقال جنین, تکنیکهای کمک باروری, پیامد درمان, پیامد باروری.
Endometrioma, Embryo transfer, Assisted reproductive technique, Treatment outcome, Pregnancy outcome.
857
870
http://ijrm.ir/browse.php?a_code=A-10-330-1&slc_lang=en&sid=1
Parisa
Pirooznia
parisapirooznia1354@gmail.com