en اثربخشی تزریق پلاسمای غنی از پلاکت به داخل تخمدان بر نتایج لقاح مصنوعی در بیماران با پاسخ تخمدانی ضعیف: یک مرور سیستماتیک Reproductive Biology Review article Review Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="FA" mitra="" style="font-family:">مقدمه: </span></b><span b="" lang="FA" mitra="" style="font-family:">اثرات سودمند و بلندمدت پلاسما غنی از پلاکت تخمدانی (</span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PRP</span></span><span b="" lang="FA" mitra="" style="font-family:">) در چرخه‌های فناوری کمک‌باروری همچنان مورد بحث و اختلاف نظر است.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="FA" mitra="" style="font-family:">هدف: </span></b><span b="" lang="FA" mitra="" style="font-family:">هدف مطالعه حاضر تعیین تأثیر </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PRP</span></span><span b="" lang="FA" mitra="" style="font-family:"> تخمدانی بر پیامدهای لقاح آزمایشگاهی در زنان با پاسخ ضعیف تخمدانی است.</span><b><span dir="LTR" style="font-family:"Arial",sans-serif"></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="FA" mitra="" style="font-family:">مواد و روش&shy; ها: </span></b><span b="" lang="FA" mitra="" style="font-family:">این مطالعه به‌صورت مرور نظام‌مند به منظور پاسخ به سؤال پژوهش از طریق فرآیند جستجوی ساخت‌یافته انجام شد. بانک‌های اطلاعاتی </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PubMed</span></span><span b="" lang="FA" mitra="" style="font-family:">،</span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">ScienceDirect</span></span><span b="" lang="FA" mitra="" style="font-family:">،</span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Scopus</span></span><span b="" lang="FA" mitra="" style="font-family:">،</span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Web of Science</span></span><span b="" lang="FA" mitra="" style="font-family:">،</span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Embase</span></span><span b="" lang="FA" mitra="" style="font-family:">،</span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Cochrane</span></span><span b="" lang="FA" mitra="" style="font-family:"> و موتور جستجوی </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Google Scholar</span></span><span b="" lang="FA" mitra="" style="font-family:"> با استفاده از کلیدواژه‌هایی همچون </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">بارداری بالینی</span>&quot;<span b="" lang="FA" mitra="" style="font-family:">، </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">تولد زنده</span>&quot;<span b="" lang="FA" mitra="" style="font-family:">، </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">سقط جنین</span>&quot;<span b="" lang="FA" mitra="" style="font-family:">، </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">پاسخ ضعیف تخمدان</span>&quot;<span b="" lang="FA" mitra="" style="font-family:">، </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">پلاسما غنی از پلاکت</span>&quot;<span b="" lang="FA" mitra="" style="font-family:"> و </span>&quot;<span b="" lang="FA" mitra="" style="font-family:">لقاح آزمایشگاهی</span>&quot;<span b="" lang="FA" mitra="" style="font-family:"> مورد جستجو قرار گرفتند. جستجو بدون محدودیت زمانی تا تاریخ ۲۰ دسامبر ۲۰۲۴ انجام شد. پس از غربالگری عنوان، چکیده و متن کامل ۶۶۴۶ مطالعه، در نهایت ۱۴ مطالعه برای ورود به مرور انتخاب شدند.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span b="" lang="FA" mitra="" style="font-family:">نتایج: </span></b><span b="" lang="FA" mitra="" style="font-family:">در 3 مطالعه، هیچ اثر قابل توجهی بر نرخ سقط جنین مشاهده نشد، اما در یک مطالعه هیچ موردی از سقط جنین در گروه مداخله گزارش نشد که این امر نگرانی‌هایی درباره نقش احتمالی این روش ایجاد کرده است. در 5 مطالعه، </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PRP</span></span><span b="" lang="FA" mitra="" style="font-family:"> به طور معناداری موجب افزایش موفقیت بارداری با لقاح آزمایشگاهی شد. در مقابل، 6 مطالعه این اثر را معنی&shy;دار ندانستند و 2 مطالعه نتایج غیرقطعی گزارش کردند. در خصوص تولد زنده، 5 مطالعه تأثیر مثبت </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PRP</span></span><span b="" lang="FA" mitra="" style="font-family:"> را نشان دادند، در حالی که 3 مطالعه نتایج غیر معنی&shy;دار و 2 مطالعه نتایج غیرقطعی گزارش کرده‌اند. یک مطالعه افزایش نرخ بارداری پایدار در گروه </span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PRP</span></span><span b="" lang="FA" mitra="" style="font-family:"> را نشان داد و 2 مطالعه افزایش میزان لانه‌گزینی را گزارش کردند.</span><b><span dir="LTR" style="font-family:"Arial",sans-serif"></span></b></span></span></span></span></span><br> <b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:">نتیجه&shy; گیری: </span></span></span></b><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:">اثربخشی </span></span></span><span style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">PRP</span></span></span><span dir="RTL" lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" mitra="" style="font-family:"> تخمدانی در درمان ناباروری با توجه به نتایج متناقض مطالعات، همچنان مشخص نیست.</span></span></span></div> <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b> <span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The beneficial </span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">and long-term </span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">effects of ovarian platelet-rich plasma (PRP) in assisted reproductive technology cycles are still debatable. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> The aim of the current study is to determine the effect of ovarian PRP on the outcome of in vitro fertilization in women with poor ovarian response</span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This is a systematic review conducted to address the research question through a structured search process. We searched databases including PubMed, ScienceDirect, Scopus, Web of Science, Embase, Cochrane,</span></span> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">and Google Scholar search engine </span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">using keywords such as &quot;clinical pregnancy&quot;, &quot;live birth&quot;, &quot;miscarriage&quot;, &quot;poor ovarian response&quot;, &quot;platelet-rich plasma&quot;, and &quot;in vitro fertilization&quot;. The search was conducted without a time limit until December 20, 2024. After screening the titles, abstracts, and full texts of 6646 studies, 14 studies were ultimately selected for inclusion in the review.</span></span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results</span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">:</span></span></b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> In 3 studies, no significant effect was observed on abortion rates, but in 1 study, no abortions were reported in the intervention group, raising concerns about the possible role of this procedure. In 5 studies, PRP significantly increased pregnancy success with </span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">in vitro fertilization</span></span><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">. In contrast, 6 studies found this effect to be non-significant, and 2 reported inconclusive results. In terms of live birth, 5 studies showed a positive effect of PRP, but 3 studies reported non-significant results, and 2 studies reported inconclusive results. One study showed an increase in ongoing pregnancy rates in the PRP group, and 2 studies showed an increase in implantation.</span></span></span></span></span><br> <b><span lang="EN" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span lang="EN" style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> The effectiveness of ovarian PRP in infertility treatment remains unclear due to conflicting results. </span></span></span></div> پلاسما غنی از پلاکت تخمدانی, پاسخ ضعیف تخمدانی, لقاح آزمایشگاهی. Ovarian platelet-rich plasma, Poor ovarian response, In vitro fertilization. 459 474 http://ijrm.ir/browse.php?a_code=A-10-2951-1&slc_lang=en&sid=1 Marzieh Zamaniyan Marziehzamaniyan@gmail.com 0000-0001-8984-5592 No Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Sepideh Peivandi dr_peyvandi@yahoo.com 0000-0003-2887-1038 No Department of Obstetrics and Gynecology, IVF Ward, Faculty of Medicine, Sexual and Reproductive Health Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. Maryam Pashazadeh M.pashazadeh98@gmail.com 0009-0002-5118-3655 No Islamic Azad University, Ardabil Branch, Ardabil, Iran. Farnaz Safarloo safarloo203@gmail.com 0009-0000-1074-4175 Yes IVF ward, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.