International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1394
7
1
gregorian
2015
10
1
13
10
online
1
fulltext
en
بررسی شیوع سندرم تخمدان پلی کیستیک و عوارض همراه آن در زنان ایرانی : مطالعه مروری و متاآنالیز
Prevalence of polycystic ovary syndrome and its associated complications in Iranian women: A meta-analysis
Original Article
Original Article
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">سندرم تخمدان پلی کیستیک</span></span> <span dir="LTR"><span style="font-size:11.0pt;">(PCOS)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> شایع ترین اختلال اندوکرین زنان در سنین باروری و شایعترین علت ناباروری ناشی ازعدم تخمک گذاری است. جهت تشخیص این سندرم معیار واحدی وجود ندارد</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">. </span></span><span dir="LTR"><span style="font-size:11.0pt;"></span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف از این مطالعه بررسی شیوع سندرم</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">تخمدان</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">پلی</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">کیستیک و عوارض ناشی از آن در زنان ایرانی به روش متاآنالیز است.</span></span><strong><span dir="LTR"></span></strong><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش ها: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">با جستجو در پایگاههای اطلاعاتی </span></span> <span dir="LTR"><span style="font-size:11.0pt;">Magiran, Irandoc, Iranmedex, SID, Pubmed</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">،</span></span><span dir="LTR"><span style="font-size:11.0pt;">GoogleScholar</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و...، مقالات مرتبط در رابطه با شیوع سندرم تخمدان</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">پلی</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">کیستیک، مورد بررسی قرار گرفته و وزن هر مطالعه با توجه به تعداد نمونه و میزان شیوع از توزیع دوجمله ای محاسبه شده است. داده ها با استفاده از روش متاآنالیز مدل اثرات تصادفی</span></span><span dir="LTR"><span style="font-size:11.0pt;">(Random effects model) </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و با نرم افزار </span></span><span dir="LTR"><span style="font-size:11.0pt;">R</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">2/11</span></span><span dir="LTR"><span style="font-size:11.0pt;">Stata Version </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> آنالیز شدند.</span></span><span dir="LTR"></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">تعداد 30 مطالعه</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">که بین سال های 1375 تا1390 انجام شده بودند، وارد</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">متاآنالیز</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">گردیدند. حجم کل نمونه 19226 زن با گروه سنی بین 54-10 سال بود. شیوع سندرم تخمدان</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">پلی</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">کیستیک طبق معیار </span></span><span dir="LTR"><span style="font-size:11.0pt;">NIH</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">، 6/8</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> (با فاصله اطمینان 95</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> :5/8 </span></span><span style="font-size:11.0pt;">–</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> 11/4) براساس معیار</span></span><span dir="LTR"><span style="font-size:11.0pt;">Rotterdam </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">، 19/5</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> (با فاصله اطمینان 95</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> : 24/2- 14/8 ) و براساس روش های سونوگرافی 41/4</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> (فاصله اطمینان 95</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> :68/5-14/4 ) تخمین زده شد. همچنین در این مطالعه، شیوع هیرسوتیسم 13</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> ،</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">آکنه 26</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> ،</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">آلوپسی آندروژنیک9</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> ،</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">اختلالات قاعدگی28</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> ، اضافه وزن 21</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">، چاقی19</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و نازایی 8</span></span><span style="font-size:11.0pt;">٪</span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> برآورد گردید.</span></span><span dir="LTR"></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه</span></span></strong> <strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">درایران شیوع سندرم تخمدان پلی کیستیک بالا نیست اما</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">با توجه به احتمال</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">ایجاد</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">عوارضی</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">مانند عوارض</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">قلبی</span></span><span dir="LTR"><span style="font-size:11.0pt;"> - </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">عروقی</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">و ناباروری،</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">پیشگیری</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">از افزایش </span></span><span dir="LTR"><span style="font-size:11.0pt;">PCOS</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> مهم</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">می</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">باشد</span></span><span dir="LTR"><span style="font-size:11.0pt;">.</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> لذا مسئولان بهداشتی و درمانی باید برنامه ریزی هایی در جهت این امر درجامعه ارائه نمایند.</span></span><span dir="LTR"><span style="font-size:11.0pt;"></span></span><br>
<strong>Background: </strong>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is the most common cause of infertility due to anovulation. There is no single criterion for the diagnosis of this syndrome.<br>
<strong>Objective: </strong>The purpose of this study was to investigate the prevalence of PCOS and its associated complications in Iranian women using meta-analysis method.<br>
<strong>Materials and Methods:</strong> Prevalence of PCOS was investigated from the SID, Goggle scholar, PubMed, Magiran, Irandoc, and Iranmedex, and weighting of each study was calculated according to sample size and prevalence of the binomial distribution. Data were analyzed using a random-effects model meta-analysis (Random effects model) and the software R and Stata Version 11.2.<br>
<strong>Results:</strong> 30 studies conducted between the years 2006 to 2011 were entered into meta-analysis. The total sample size was 19, 226 women aged between 10-45 years. The prevalence of PCOS based on National institute of child health and human disease of the U.S was, 6.8% (95 % CI: 4.11–8.5), based on Rotterdam was 19.5% (95 % CI: 2.24-8.14), and based on ultrasound was 4.41% (95% CI: 5.68-4.14). Also, the prevalence of hirsutism was estimated to be 13%, acne 26%, androgenic alopecia 9%, menstrual disorders 28%, overweight 21%, obesity 19%, and infertility 8%.<br>
<strong>Conclusion:</strong> The prevalence of PCOS in Iran is not high. However, given the risk of complications such as heart disease - cardiovascular and infertility, prevention of PCOS is important; we suggest that health officials must submit plans for the community in this respect.
سندرم تخمدان پلی کیستیک, شیوع, هیرسوتیسم, آکنه چاقی.
Polycystic ovary syndrome,Prevalence,Hirsutism,Acne,Obesity
591
604
http://ijrm.ir/browse.php?a_code=A-10-1-190&slc_lang=en&sid=1
Anahita
Jalilian
آناهیتا
جلیلیان