International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1394
2
1
gregorian
2015
5
1
13
4
online
1
fulltext
en
عدم وجود ارتباط بین پلی مورفیسمهای DRD3, CNR1 و ناهنجاریهای دیس مورفیک قبل از قاعدگی
Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders
Original Article
Original Article
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ناهنجاری های دیس مورفیک قبل از قاعدگی (</span></span><span dir="LTR"><span style="font-size:10.0pt;">PMDD</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) از جمله ناهنجاری خلقی هستند که با علائم فیزیکال و موثر در طی فاز لوتئال در خانم های متعدد رخ می دهد.</span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف این مقاله بررسی ارتباط بین پلی مورفیسم </span></span><span dir="LTR"><span style="font-size:10.0pt;">DRD3</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و پلی مورفیسم</span></span> <span dir="LTR"><span style="font-size:10.0pt;">CNR1</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">با </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMDD</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> می باشد.</span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش ها: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">51 بیمار با </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMDD</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بر اساس معیارهای </span></span><span dir="LTR"><span style="font-size:10.0pt;">DSM IV</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و 51 نمونه کنترل سالم در این مطالعه</span></span> <span dir="LTR"><span style="font-size:10.0pt;">cross sectiona</span></span><span dir="LTR"><span style="font-size:10.0pt;">l</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> وارد شدند. علائم بوسیله خود آزمایی روزانه، فرم های قبل قاعدگی ماهیانه و مصاحبه روانشناسی اندازه گیری شد.ژئوتیپ </span></span><span dir="LTR"><span style="font-size:10.0pt;">DRD3</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">CNR1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بوسیله روش </span></span><span dir="LTR"><span style="font-size:10.0pt;">Taqmanfluorogenic</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> مشخص شد.</span></span><strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"></span></span></strong><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج:</span></span></strong> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">شیوع پلی مورفیسم های </span></span><span dir="LTR"><span style="font-size:10.0pt;">DRD3</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">CNR1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بین بیماران و گروه کنترل تفاوتی نداشت.</span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه گیری: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">یافته های ما تایید کننده نقش موثری برای پلی مورفیسم های </span></span><span dir="LTR"><span style="font-size:10.0pt;">DRD3</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:10.0pt;">CNR1</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> در استعداد ابتلا به </span></span><span dir="LTR"><span style="font-size:10.0pt;">PMDD</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> نبود.</span></span>
<strong>Background: </strong>Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.<br>
<strong>Objective: </strong>The aim of this study was to investigate the association of Dopamine D3 receptor ( DRD3 ) polymorphism, and Cannabinoid receptor Type 1 ( CNR1 ) polymorphism with PMDD.<br>
<strong>Materials and Methods:</strong> Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.<br>
<strong>Results: </strong>Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.<br>
<strong>Conclusion:</strong> These findings do not support a major role of DRD3 , and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
گیرنده Cannabinoid , گیرنده دوپامین D3, سندرم قبل از قاعدگی, پلی مورفیسم ژنتیکی.
Cannabinoid receptor,Dopamine D3 receptor,Premenstrual syndrome,Genetic polymorphism.
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http://ijrm.ir/browse.php?a_code=A-10-1-242&slc_lang=en&sid=1
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