International Journal of Reproductive BioMedicine
International Journal of Reproductive BioMedicine
IJRM
Medical Sciences
http://ijrm.ir
1
admin
2476-4108
2476-3772
10.29252/ijrm
en
jalali
1394
5
1
gregorian
2015
8
1
13
6
online
1
fulltext
en
اثرات گونادوتروپین منوپوزال انسانی (hMG) بر روی زونا پلوسیدا و نتایج حاملگی در پروتکل های تحریک تخمک گذاری
Effects of human menopausal gonadotropin on zona pellucida and pregnancy outcomes of ovarian stimulation protocols
Original Article
Original Article
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مقدمه: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">گونادوتروپین منوپوزال انسانی (</span></span><span dir="LTR"><span style="font-size:11.0pt;">hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) نقش مهمی در بهبود روش های کمک باروری داشته است. ولی اثرات </span></span><span dir="LTR"><span style="font-size:11.0pt;">hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> روی رشد تخمک و نتایج ک</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ل</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">ینیکی هنوز محل بحث است.</span></span><span style="font-size:10.0pt;"></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هدف:</span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> هدف این مطالعه بررسی اثرات </span></span><span dir="LTR"><span style="font-size:11.0pt;">hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بر روی زوناپلوسیدا و نتایج کلینیکی درمان تحریک تخمک گذاری بود.</span></span><span style="font-size:10.0pt;"></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">مواد و روش ها: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">این مطالعه گذشته نگر بر روی 150 سیکل درمان پروتکل طولانی با استفاده از هورمون تحریک کننده فولیکولی نوترکیب </span></span><span dir="LTR"><span style="font-size:11.0pt;">rFSH)</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) با یا بدون </span></span><span dir="LTR"><span style="font-size:11.0pt;">hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> انجام شد. تعداد تخمک های به دست آمده، میزان باروری، میزان لانه گزینی، میزان حاملگی، ضخامت </span></span><span dir="LTR"><span style="font-size:11.0pt;">Birefringence</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و زوناپلوسیدای تخمک ها بررسی شد.</span></span><span style="font-size:10.0pt;"></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتایج: </span></span></strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">هیچ تفاوت معنی داری در تعداد اوسیت ها (0/73±13/9 </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">در مقابل</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/75±11/99، 0/06</span></span> =<span dir="LTR"><span style="font-size:11.0pt;"> (p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">، میزان بلوغ(76/84% درمقابل 83/32</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">، p=0/42</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">)</span></span> <span dir="RTL"><span style="font-family:b mitra;"><span style="font-size:11.0pt;">(</span></span></span><span dir="RTL"><span style="font-family:b mitra;"><span style="font-size:12.0pt;">84/76%</span></span></span><span style="font-family:b mitra;"> در مقابل 83/32، 0/42%</span>=p<span style="font-family:b mitra;"><span style="font-size:11.0pt;">)، میزان حاملگی (</span></span><span style="font-family:b mitra;">37/31% در مقابل 37/66%،0/96 =</span>p<span style="font-family:b mitra;"><span style="font-size:11.0pt;">) و میزان لانه گزینی امبریو (28/97% در مقابل 23/26%،p=0/30</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) در گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH+hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> با گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بدست نیامد. به هر حال میزان باروری (82/95% در مقابل 78/75%، p=0/02</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) متفاوت بود. </span></span><span dir="LTR"><span style="font-size:11.0pt;">Birefringence</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> زوناپلوسیدا در گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH+hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> کمتر از گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بود (0/50±6/</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">70</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">در مقابل</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/31±7/04، 0/53=</span></span><span dir="LTR"><span style="font-size:11.0pt;">p</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">). اندازه ضخامت زوناپلوسیدا در متافاز </span></span><span dir="LTR"><span style="font-size:11.0pt;">II</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> در گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH+hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> در روزهای اول (0/14±19/20 </span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">در مقابل</span></span> <span style="font-size: 11pt; "><font face="b mitra">0/10±18/75، 0/01=p</font></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) و دوم (0/12±18/</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;">69</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">در مقابل</span></span> <span style="font-family:b mitra;"><span style="font-size:11.0pt;">0/14±0/00،</span></span><span dir="RTL"></span><font face="B Mitra"><span style="font-size: 15px;">18/17=p</span></font><span style="font-family:b mitra;"><span style="font-size:11.0pt;">) باروری هر دو بیشتر از گروه </span></span><span dir="LTR"><span style="font-size:11.0pt;">r-FSH</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> بود.</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"></span></span><br>
<strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;">نتیجه گیری: </span></span></strong><span dir="LTR"><span style="font-size:11.0pt;">hMG</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> به طور مثبتی دارای اثرات بهبود باروری تخمک و همچنین </span></span><span dir="LTR"><span style="font-size:11.0pt;">Birefringence</span></span><span style="font-family:b mitra;"><span style="font-size:11.0pt;"> و ضخامت زوناپلوسیدا می باشد.</span></span><strong><span style="font-family:b mitra;"><span style="font-size:11.0pt;"></span></span></strong>
<strong>Background:</strong> Human menopausal gonadotropin (hMG) has contributed many improvements to human assisted reproduction. However, effects of hMG on oocyte development and clinical results remain controversial.<br>
<strong>Objective:</strong> This study was conducted to investigate the effects of hMG on the zona pellucida of oocytes, as well as clinical results in superovulation treatment.<br>
<strong>Materials and Methods:</strong> This retrospective study was performed with 150 cycles of long-protocol treatment using recombinant follicle-stimulating hormone (r-FSH) with or without hMG. The number of retrieved oocytes, fertilization rate, implantation rate, pregnancy rate, and birefringence and thickness of the zona pellucida of oocytes were investigated.<br>
<strong>Results:</strong> No significant differences were existed in r-FSH +hMG, and r-FSH groups in the number of retrieved oocytes (11.99±0.75 vs. 13.9±0.73, p=0.06), maturation rate (84.76% vs. 83.32%, p=0.42), pregnancy rate (37.31% vs. 37.66%, p=0.96), and embryo implantation rate (28.97% vs. 23.26%, p=0.30). However, fertilization rate (82.95% vs. 78.75%; p=0.02) was different. Zona pellucida birefringence was lower in the r-FSH +hMG group than in the r-FSH group (6.70±0.50 vs. 7.04±0.31; p=0.53). Thickness values of the metaphase-II zona pellucida of the r-FSH +hMG group on the first (19.20±0.14 vs. 18.75±0.10; p=0.01) and second (18.69±0.12 vs. 18.17±0.14; p=0.00) days of insemination were both higher than those of the r-FSH group.<br>
<strong>Conclusion: </strong>hMG positively influenced the improvement of oocyte fertilization, as well as the birefringence and thickness of zona pellucida.
انسان, Birefringence, تخمک, زونا پلوسیدا, حاملگی
Humans,Birefringence,Oocyte,Zona pellucida,Pregnancy
337
344
http://ijrm.ir/browse.php?a_code=A-10-1-222&slc_lang=en&sid=1
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