en Original Article Original Article <strong>Background:</strong> Platelets contain a significant amount of growth factors that have positive effects on local tissue repair and endometrial receptivity.<br> <strong>Case:</strong> Here we present a 45-yr-old woman with primary infertility and two failed in vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five consecutive frozen-thawed embryo transfer cycles with good quality embryos were performed within 2 yr. With the diagnosis of recurrent implantation failure (RIF), the patient was treated for improving endometrial receptivity with intrauterine administration of autologous platelet-rich plasma (PRP), 24 hr before embryo transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the cesarean section.<br> <strong>Conclusion: </strong>Extensive literature search suggests that this is the first successful pregnancy after administration of PRP in a woman with RIF. Local administration of PRP before embryo transfer may play a vital role in successful implantation Recurrent implantation failure, Platelet-rich plasma, Embryo transfer, Assisted reproductive technology, Pregnancy outcome, Embryo implantation 803 806 http://ijrm.ir/browse.php?a_code=A-10-1-366&slc_lang=en&sid=1 Marzie Farimani Bahmanzadeh12@yahoo.com No Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Jalal Poorolajal Bahmanzadeh12@yahoo.com No Research Center for Health Sciences, Hamadan University of Medical sciences, Hamadan, Iran Soghra Rabiee Bahmanzadeh12@yahoo.com No Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Maryam Bahmanzadeh Bahmanzadeh12@yahoo.com Yes Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran