Volume 19, Issue 7 (July 2021)                   IJRM 2021, 19(7): 599-606 | Back to browse issues page


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Hajshafiha M, Oshnouei S, Mostafavi M, Dindarian S, Kiarang N, Mohammadi S. Evaluation of the relationship between serum estradiol levels on human chorionic gonadotropin administration day and intracytoplasmic sperm injection outcomes: A retrospective population-based study. IJRM. 2021; 19 (7) :599-606
URL: http://ijrm.ssu.ac.ir/article-1-1524-en.html
1- Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia University of Medical Sciences, Urmia, Iran.
2- Clinical Research Development Unit, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.
3- Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
4- Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. , sedra.mohammadi1993@gmail.com
Abstract:   (516 Views)
Background: The correlation between high estradiol (E2) levels induced by controlled ovarian hyperstimulation (COH) and pregnancy is controversial.
Objective: To assess the effect of serum E2 levels on the day of human chorionic gonadotropin administration on the intracytoplasmic sperm injection (ICSI) outcome.
Materials and Methods: The study included 551 participants who had undergone ICSI between May 2014 and May 2016. Based on E2 levels, the individuals aged < 37 yr (n = 502) and aged 37-42 yr (n = 49) were categorized into six and three groups, respectively. ICSI outcomes including the number of retrieved oocytes (NRO), number of embryos (NE), pregnancy rate, and abortion rate were analyzed in both groups.
Results: Among participants below 37 yr, the NRO and NE were 8.69 ± 3.82 and 5.24 ± 2.32, respectively and they had a significant correlation with the E2 level on human chorionic gonadotropin administration day (p < 0.001 for both). Among participants above 37 yr, NRO and NE were 5.18 ± 3.17, 3.40 ± 2.23, respectively and the NRO (p < 0.001), NE (p < 0.001), pregnancy rate (p < 0.001), abortion rate (p = 0.007) and the number of grade A and B embryos (p = 0.003) had a significant association with the E2 level.
Conclusion: COH is a costly procedure that may have negative effects on endometrial receptivity. Thus, in order to prevent these effects and also to reduce the costs of COH, we recommend gaining optimum number of oocytes rather than maximum number during the procedure.
 
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Type of Study: Original Article | Subject: Fertility & Infertility

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