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Volume 17, Issue 11 (November 2019)
IJRM 2019, 17(11): 831-840 |
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Hamedanian L, Badehnoosh B, Razavi-Khorasani N, Mohammadpour Z, Hassan M. Evaluation of vitamin D status, parathyroid hormone, and calcium among Iranian pregnant women with preeclampsia: A case-control study. IJRM 2019; 17 (11) :831-840
URL: http://ijrm.ir/article-1-1723-en.html
URL: http://ijrm.ir/article-1-1723-en.html
Laaya Hamedanian1 
, Bita Badehnoosh2 , Niloofar Razavi-Khorasani3 , Zinat Mohammadpour3 , Mozaffari-Khosravi Hassan * 4
, Bita Badehnoosh2 , Niloofar Razavi-Khorasani3 , Zinat Mohammadpour3 , Mozaffari-Khosravi Hassan * 4
1- International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Department of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
3- Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4- 4Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , mozaffari.kh@gmail.com
2- Department of Gynecology and Obstetrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
3- Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
4- 4Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , mozaffari.kh@gmail.com
Abstract: (2635 Views)
Background: Preeclampsia is considered as a serious life-threatening condition that could affect both maternal and fetal outcome. Many studies have examined the association of nutritional factors with the incidence of preeclampsia. However, little is known about the possible role of vitamin D in the development of preeclampsia among the Iranian population.
Objective: The aim of the present study was to evaluate the association between vitamin D status and preeclampsia.
Materials and Methods: A total of 120 pregnant women who were referred to Kamali and Alborz General Hospital located in the Karaj City were enrolled in this study and categorized into preeclamptic and control groups (n = 60/each). The clinical details of patients such as demographic characteristics and laboratory findings were obtained from the patients. The serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured. Multivariate logistic regression analysis was used to assess for independent predictors of preeclampsia.
Results: The mean age among pregnant women with preeclampsia and control group were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the control group (p < 0.001). The serum vitamin D levels were significantly lower in women with preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for confounding factors.
Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the pregnant women diagnosed with preeclampsia compared to the healthy subjects. However, no correlation was observed between the vitamin D status and the risk of preeclampsia development.
Objective: The aim of the present study was to evaluate the association between vitamin D status and preeclampsia.
Materials and Methods: A total of 120 pregnant women who were referred to Kamali and Alborz General Hospital located in the Karaj City were enrolled in this study and categorized into preeclamptic and control groups (n = 60/each). The clinical details of patients such as demographic characteristics and laboratory findings were obtained from the patients. The serum levels of vitamin D, calcium, phosphorus, and parathormone were also measured. Multivariate logistic regression analysis was used to assess for independent predictors of preeclampsia.
Results: The mean age among pregnant women with preeclampsia and control group were 31.48 ± 5.25 and 29.01 ± 5.28, respectively. The mean body mass index among the preeclamptic group was 27.92 ± 4.98, which was significantly higher compared to the control group (p < 0.001). The serum vitamin D levels were significantly lower in women with preeclampsia compared to the control subjects (p = 0.007). Moreover, no correlation between vitamin D deficiency and predisposing factors of preeclampsia was observed after adjusting for confounding factors.
Conclusion: Our study revealed that serum vitamin D level is significantly lower in among the pregnant women diagnosed with preeclampsia compared to the healthy subjects. However, no correlation was observed between the vitamin D status and the risk of preeclampsia development.
Type of Study: Original Article |
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