Volume 8, Issue 4 (7-2010)                   IJRM 2010, 8(4): 197-202 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arefi S, Babashamsi M, Shariat Panahi P, Asgharpour Saruiy L, Zeraati H. C-reactive protein level and pregnancy rate in patients undergoing IVF/ICSI. IJRM. 2010; 8 (4) :197-202
URL: http://ijrm.ssu.ac.ir/article-1-191-en.html
1- Reproductive Biotechnology Research Center, Avicenna Research institute, ACECR, Tehran, Iran
2- Monoclonal Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , babashams@avicenna.ac.ir
3- Payam Noor University, Tehran, Iran
4- Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (1933 Views)
Background: C-reactive protein (CRP) can be increased after hormonal stimulations. The changes of CRP might affect the success of in-vitro fertilization (IVF).

Objective: The aim of this study was to determine the possible relationship between the serum CRP level and outcome of controlled ovarian stimulation, and pregnancy rate in patients undergoing IVF or intra cytoplasmic sperm injection (ICSI).
Materials and Methods: This prospective cross sectional study was performed in Avicenna Infertility Clinic on 70 consecutive infertile patients (Jan 2008-Aug 2009) who were candidate for IVF/ICSI, using standard long GnRH agonist protocol. Blood was drawn 4 times during the cycle, on first day of stimulation, the day of HCG injection, the day of ovum pick up, and the day of embryo transfer.
Results: In 82.2% of cases, the serum CRP level was higher in day of HCG injection than first day of stimulation and also the day of ovum pick up than the day of HCG injection. The ratio of CRP level in the day of transfer to the day of ovum pick up, was significantly higher (ratio1.23) in patients who became pregnant after ICSI (p =0001). All patients with less than this Ratio have not been pregnant.
Conclusion: Controlled ovarian hyper stimulation and puncture of ovaries can potentiate systemic stimulation. Increasing serum CRP level in day of embryo transfer rather than ovum pick up can predict the success in patients undergoing IVF/ICSI.
Full-Text [PDF 131 kb]   (519 Downloads) |   |   Full-Text (HTML)  (202 Views)  
Type of Study: Original Article |

1. Wood WG, Lüdemann J, Mitusch R, Heinrich J, Maass R, Frick U. Evaluation of a sensitive immunoluminometric assay for the determination of C-reactive protein (CRP) in serum and plasma and the establishment of reference ranges for different groups of subjects. Clin Lab 2000; 46: 131-140.
2. Trevisanuto D, Doglioni N, Altinier S, Zaninotto M, Plebani M, Zanardo V. High-sensitivity C-reactive protein in umbilical cord of small-for-gestational-age neonates. Neonatology 2007; 91: 186-189. [DOI:10.1159/000097451]
3. Lohsoonthorn V, Qiu C, Williams MA. Maternal serum C-reactive protein concentrations in early pregnancy and subsequent risk of preterm delivery. Clin Biochem 2007; 40: 330-335. [DOI:10.1016/j.clinbiochem.2006.11.017]
4. Garcia RG, Celedón J, Sierra-Laguado J, Alarcón MA, Luengas C, Silva F, et al. Raised C-reactive protein and impaired flow-mediated vasodilation precede the development of preeclampsia. Am J Hypertens 2007; 20: 98-103 [DOI:10.1016/j.amjhyper.2006.06.001]
5. Coussons-Read ME, Okun ML, Nettles CD. Psychosocial stress increases inflammatory markers and alters cytokine production across pregnancy. Brain Behav Immun 2007; 21: 343-350. [DOI:10.1016/j.bbi.2006.08.006]
6. de Maat MP, Madsen JS, Langdahl B, Bladbjerg EM, Tofteng CL, Abrahamsen B, et al. Genetic variation in estrogen receptor, C-reactive protein and fibrinogen does not predict the plasma levels of inflammation markers after long term hormone replacement therapy. Thromb Haemost 2007; 97: 234-239. [DOI:10.1160/TH06-08-0426]
7. Meier Ewert HK, Ridker PM, Rifaei M, Price N, Dinges DF, Mullington JM. Absence of diurnal variation of C-rective protein level in healthy human subjects. Clin Chem 2001; 47: 426-430.
8. Störk S, Bots ML, Grobbee DE, van der Schouw YT. Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. J Intern Med 2008; 264:245 -253. [DOI:10.1111/j.1365-2796.2008.01946.x]
9. Wunder DM, Dretschmer R, Bersinger NA. Concentration of leptine and C-reactive protein in Serum and follicular fluid during assisted reproductive cycles. Hum Reprod 2005; 20: 1266-1271. [DOI:10.1093/humrep/deh767]
10. Orvieto R, Chen R, Ashkenazi J, Ben-Harush A, Bar J, Fisch B. C- Reactive protein level in patients undergoing controlled ovarian hyperstimulation for IVF cycle. Human Reprod 2004; 19: 357-359. [DOI:10.1093/humrep/deh089]
11. Wander K, Brindle E, O'Connor KA. C-reactive protein across the menstrual cycle. Am J Phys Anthropol 2008; 136: 138-146. [DOI:10.1002/ajpa.20785]
12. Orvieto R, Schwartz A, Bar Hava I, Abir R, Ashkenazi A, Lamarka A, et al. Controlled ovarian hyperstimulation -a state of endothelial activation. Am J Reprod Immunol 2000; 44: 257-260. [DOI:10.1111/j.8755-8920.2000.440501.x]
13. Levin I, Gamzu R, Pauzner D, Rogowski O, Shapira I, Maslovitz S,et al.Elevated level of CRP in Ovarian hyper stimulation syndrome: an unrecognized potential hazards? BGOJ 2005; 112: 952-955. [DOI:10.1111/j.1471-0528.2005.00602.x]
14. Orvieto R, Zagatsky I, Yulzari-Roll V, La Marca A, Fisch B.Substituting human chorionic gonadotropin by gonadotropin-releasing hormone agonist to trigger final follicular maturation, during controlled ovarian hyperstimulation, results in less systemic inflammation. Gynecol Endocrinol 2006; 22:437.440. [DOI:10.1080/09513590600881339]
15. Sacks GP, Seyani I, Lavery S, Trew G. Maternal C-reactive protein levels are raised at 4 weeks gestation. Hum Reprod 2004; 19, 1025-1030. [DOI:10.1093/humrep/deh179]
16. Almagor M, Hazav A, Yaffe H. The levels of C-reactive protein in women treated by IVF. Hum Reprod 2004; 19, 104-106. [DOI:10.1093/humrep/deh036]
17. Orvieto R, Ben-Rafael Z, Schwartz A, Schwartz A, Abir R, Fisch B, et al. Soluble L-selectin levels during controlled ovarian hyperstimulation. Gynecol Endocrinol 2001; 15, 29-33. [DOI:10.1080/gye.]

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb