International Journal of
Reproductive Biomedicine
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Volume 19, Issue 11 (November 2021)
IJRM 2021, 19(11): 979-986 |
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Singh V, Tamar N, Lone Z, Das E, Sahu R, Majumdar S. Association between serum 25-hydroxy vitamin D level and menstrual cycle length and regularity: A cross-sectional observational study. IJRM 2021; 19 (11) :979-986
URL: http://ijrm.ir/article-1-1948-en.html
URL: http://ijrm.ir/article-1-1948-en.html
1- Obstetrics and Gynecology Department, Aiims, Raipur, India. , ddvinitasingh@gmail.com
2- Obstetrics and Gynecology Department, Aiims, Raipur, India.
2- Obstetrics and Gynecology Department, Aiims, Raipur, India.
Abstract: (1528 Views)
Background: Research examining the role of vitamin D deficiency and the development of menstrual disorders in women is of widespread interest. Studies have been published showing that supplementation with high-dose vitamin D can lead to the restoration of the menstrual cycle. We lack adequate information regarding the effect of vitamin D levels on the physiology of menstruation and further on fertility in women of reproductive age due to the contradictory results reported by studies.
Objective: To study the association of 25-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity.
Materials and Methods: In this cross-sectional study, serum vitamin D level of 166 women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = 83) between April-June 2019 were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = 83).
Results: A decreased level of vitamin D was associated with a 13.3 times odds of an irregular cycle (OR (95% CI): 13.30 (5.79-30.60), p < 0.001). 25-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < 0.001) in mean vitamin D levels among the females with irregular cycles vs. regular cycles.
Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed.
Objective: To study the association of 25-hydroxy vitamin D with menstrual cycle characteristics including long and short cycle length and cycle irregularity.
Materials and Methods: In this cross-sectional study, serum vitamin D level of 166 women attending an outpatient department with menstrual irregularities after excluding all obvious causes of menstrual disorders (n = 83) between April-June 2019 were measured and were compared with women of similar profiles with complaints other than menstrual irregularities (n = 83).
Results: A decreased level of vitamin D was associated with a 13.3 times odds of an irregular cycle (OR (95% CI): 13.30 (5.79-30.60), p < 0.001). 25-hydroxy vitamin D was not associated with age or body mass index. We found a significant difference (p < 0.001) in mean vitamin D levels among the females with irregular cycles vs. regular cycles.
Conclusion: Vitamin D plays a role in the physiology of reproduction specific to the menstrual cycle and ovulation. Long-term prospective studies assessing the exact cutoff value and the exact dose of supplementation required are needed.
Keywords: Menstrual disturbances, Ovulation, Reproductive period, Vitamin D deficiency, Dietary supplements, Polycystic ovarian syndrome.
Type of Study: Original Article |
Subject:
Cellular and Molecular Biology of Reproduction
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