Volume 10, Issue 1 (7-2012)                   IJRM 2012, 10(1): 59-66 | Back to browse issues page

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Karimi S, Yavarian M, Azinfar A, Rajaei M, Azizi Kootenaee M. Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population. IJRM 2012; 10 (1) :59-66
URL: http://ijrm.ir/article-1-248-en.html
Evaluation the frequency of factor V Leiden mutation in pregnant women with preeclampsia syndrome in an Iranian population
Samieh Karimi1 , Majid Yavarian2 , Azadeh Azinfar * 3, Minoo Rajaei1 , Maryam Azizi Kootenaee1
1- Department of Obstetrics and Gynecology, Hormozgan Fertility and Infertility Research Center, Shariati Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2- Department of Human Molecular and Clinical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Obstetrics and Gynecology, Hormozgan Fertility and Infertility Research Center, Shariati Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran , aazinfar@yahoo.com
Abstract:   (3972 Views)
Background: Role of genetic factors in etiology of preeclampsia is not confirmed yet.
Objective: Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of factor V Leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of Persian Gulf in Iran, were considered.
Materials and Methods: Between Jan. 2008 and Dec. 2009, in a nested case control study, pregnant women with preeclampsia (N=198) as cases and healthy (N=201) as controls were enrolled in the study. DNA were extracted from 10 CC peripheral blood and analyzed for presence of factor V Leiden mutation in these subjects. The maternal and neonatal outcomes of pregnancy according to the distribution of factor V Leiden were also compared among cases.
Results: In total, 17(8.6%) of cases and 2(1%) of controls showed the factor V Leiden mutation. The incidence of factor V Leiden was typically higher in preeclamptic women than control group (OR: 9.34 %95 CI: 2.12-41.01). There was no difference in incidence rate of preterm delivery< 37 weeks (OR: 1.23 %95 CI: 0.38-4.02), very early preterm delivery<32 weeks (OR: 1.00 %95 CI: 0.12-8.46), intra uterine fetal growth restriction (IUGR) (OR: 1.32 %95 CI: 0.15-11.30 ),and the rate of cesarean section (OR: 0.88 %95 CI: 0.29-2.62 ) among cases based on the prevalence of factor V Leiden mutation.
Conclusion: The pregnant women with factor V Leiden mutation are prone for preeclampsia syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women. 
Keywords: Preeclampsia, Factor V Leiden mutation, Obstetric complication, Iran.
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Type of Study: Original Article |
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