Volume 10, Issue 1 (7-2012)                   IJRM 2012, 10(1): 53-58 | Back to browse issues page

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Kara M, Kutlu T, Sofuoglu K, Devranoglu B, Cetinkaya T. Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome. IJRM 2012; 10 (1) :53-58
URL: http://ijrm.ir/article-1-250-en.html
Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome
Mustafa Kara * 1, Tayfun Kutlu2 , Kenan Sofuoglu2 , Belgin Devranoglu2 , Tansel Cetinkaya2
1- Department of Obstetrics and Gynecology, Medical Faculty, Bozok University, Yozgat, Turkey , mustafa.kara@bozok.edu.tr
2- Zeynep Kamil Women's and Children's Hospital, Reproductive Medicine and IVF Unit, Istanbul, Turkey
Abstract:   (2913 Views)
Background: Estradiol (E2) is required for follicular development and play an important role in embryo implantation.
Objective: The aim of this study was to assess the impact of serum E2 levels on the day of hCG administration in IVF-ICSI patients who are performed controlled ovarian hyperstimulation (COH).
Materials and Methods: A total of 203 women who were undergone one time IVF cyclus were evaluated in this cross sectional study. All the patients were treated either with long protocol or with microdose flare protocol. The patients were categorized into five groups according to the serum E2 levels on the day of hCG administration.
Results: The mean number of the retrieved oocytes was (NRO) 10.6±6.7, mean fertilization rate was 55.7±24.8, and implantation rate was 9.0±19.2. Of 203 patients, 43 (21%) patients were pregnant. When the overall results are examined, the number of the retrieved oocytes and the number of transferred embryos were better in patients with serum E2 levels >4000 pg/ml and these values were statistically significant. There were no statistical difference in patients 37 years or older. In women ?36 years old, the IVF-ICSI outcomes were better in patients with serum E2 levels >4000 pg/ml.
Conclusion: In spite of the lack of high quality evidence to support a positive association between serum E2 levels and IVF-ICSI outcomes, this study shows that high E2 levels during COH might be associated with an increased potential of pregnancy depending on better ovarian response. When the overall results are examined, the best scores were in patients with serum E2 levels >4000 pg/ml.
Keywords: In-vitro fertilization, Estradiol, Pregnancy, Follicle stimulating hormone.
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Type of Study: Original Article |
References
1. Joo BS, Park SH, Min AnB, Kim KS, Moon SE, Moon HS. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration dependent manner. Fertil Steril 2010; 93: 442-446. [DOI:10.1016/j.fertnstert.2009.02.066]
2. Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A, Simon C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril 2001; 76: 962-968. [DOI:10.1016/S0015-0282(01)02018-0]
3. Friedler S, Zimerman A, Schachter M, Raziel A, Strassburger D, Ron ElR. The midluteal decline in serum estradiol levels is drastic but not deleterious for implantation after in vitro fertilization and embryo transfer in patients with normal or high responses. Fertil Steril 2005; 83: 54-60. [DOI:10.1016/j.fertnstert.2004.08.017]
4. Mitwally MFM, Bhakoo HS, Crickard K, Sullivan MW, Batt RE, Yeh J. Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization–embryo transfer. Fertil Steril 2006; 86: 588-596. [DOI:10.1016/j.fertnstert.2006.02.086]
5. Blazar AS. Serum estradiol positively predicts outcomes in patients undergoing in vitro fertilization. Fertil Steril 2004; 81: 1707-1709. [DOI:10.1016/j.fertnstert.2003.10.039]
6. Kosmas I P, Kolibianakis EM, Devroey P. Association of estradiol levels on the day of hCG administration and pregnancy achievement in IVF: a systematic review. Hum Reprod 2004; 19: 2446-2453. [DOI:10.1093/humrep/deh473]
7. Ng EHY, Yeung WSB, Lau EYL, So WWK, Ho PC. High serum estradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen- thawed embryo transfer cycles. Hum Reprod 2000; 15: 250-255. [DOI:10.1093/humrep/15.2.250]
8. Özçakir HT, Tavmergen Göker EN, Terek MC. Relationship of follicle number, serum estradiol level, and other factors to clinical pregnancy rate in gonadotropin-induced intrauterine insemination cycles. Arch Gynecol Obstet 2002; 266: 18-20. [DOI:10.1007/PL00007493]
9. Sharara FI, McClamrock HD. High estradiol levels and high oocyte yield are not detrimental to in vitro fertilization outcome. Fertil Steril 1999; 72: 401-405. [DOI:10.1016/S0015-0282(99)00293-9]
10. Pelinck MJ, Hoek A, Simons AH, Heineman MJ. Efficacy of natural cy-cle IVF: a review of the literature. Hum Reprod Update 2002; 8: 129-139. [DOI:10.1093/humupd/8.2.129]
11. van der Gaast MH, Eijkemans MJ, van der Net JB, de Boer EJ, Burger CW, van Leeuwen FE, et al. Optimum number of oocytes for a successful first IVF treatment cycle. Reprod Biomed Online 2006; 13: 476-480. [DOI:10.1016/S1472-6483(10)60633-5]
12. DiLuigi AJ, Nulsen JC. Effects of gonadotropin-releasing hormone agonists and antagonists on luteal function. Curr Opin Obestet Gynecol 2007; 19: 258-265. [DOI:10.1097/GCO.0b013e3281338874]
13. Kolibianakis EM, Albano C, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin releasing hormone antagonists. Fertil Steril 2004; 82: 102-107. [DOI:10.1016/j.fertnstert.2004.01.027]
14. Hendriks DJ, Klinkert ER, Bancsi LF, Looman CW, Habbema JD, te Velde ER, et al. Use of stimulated serum estradiol measurements for the prediction of hyperresponse to ovarian stimulation in in vitro fertilization (IVF). J Assist Reprod Genet 2004; 21: 65-72. [DOI:10.1023/B:JARG.0000027016.65749.ad]
15. Bourgain C, Ubaldi F, Tavaniotou A, Smitz J, Van Steirteghem AC, Devroey P. Endometrial hormone receptors and proliferation index in the periovulatory phase of stimulated embryo transfer cycles in comparison with natural cycles and relation to clinical pregnancy outcome. Fertil Steril 2002; 78: 237-243. [DOI:10.1016/S0015-0282(02)03228-4]
16. Baser GS, O WS, Ng EH, Ho PC. Morphometric analysis of periimplantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation. Hum Reprod 2001; 16: 435-440. [DOI:10.1093/humrep/16.3.435]
17. Mendoza C, Ruiz-Requena E, Ortega E, Cremades N, Martinez F, Bernabeu R, et al. Follicular fluid markers of oocyte developmental potential. Hum Reprod 2002; 17: 1017-1022. [DOI:10.1093/humrep/17.4.1017]
18. Papageorgiou T, Guibert J, Goffinet F, Patrat C, Fulla Y, Janssens Y, et al. Percentile curves of serum estradiol levels during controlled ovarian stimulation in 905 cycles stimulated with recombinant FSH show that high estradiol is not detrimental to IVF outcome. Hum Reprod 2002; 17: 2846-2850. [DOI:10.1093/humrep/17.11.2846]
19. Chen CH, Zhang X, Barnes R, Confino E, Milad M, Puscheck E, Kazer RR. Relationship between peak serum E2 levels and treatment outcome in in-vitro fertilization cycles after embryo transfer on day 3 or day 5. Fertil Steril 2003; 80: 75-79. [DOI:10.1016/S0015-0282(03)00504-1]
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