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Reproductive Biomedicine
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Volume 10, Issue 3 (7-2012)
IJRM 2012, 10(3): 243-248 |
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Moradi M, Alemi M, Moradi A, Izadi B, Parhodah F, Torkaman Asadi F. Does inhibin-B help us to confidently refuse diagnostic testicular biopsy in azoospermia?. IJRM 2012; 10 (3) :243-248
URL: http://ijrm.ir/article-1-282-en.html
URL: http://ijrm.ir/article-1-282-en.html
Mahmoudreza Moradi * 
1, Mohsen Alemi2 , Asaad Moradi2 , Babak Izadi3 , Farajollah Parhodah2 , Fatemeh Torkaman Asadi4
1, Mohsen Alemi2 , Asaad Moradi2 , Babak Izadi3 , Farajollah Parhodah2 , Fatemeh Torkaman Asadi4
1- Infertility Research Center, Urology-Nephrology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran , drmrmoradi@yahoo.com
2- Infertility Research Center, Urology-Nephrology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran
2- Infertility Research Center, Urology-Nephrology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran
Abstract: (2604 Views)
Background: In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved.
Objective: To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia.
Materials and Methods: This cross-sectional study was done during July 2006 to September 2007 on 41 patients with azoospermia. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients.
Results: Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal (p=0.001). Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome (p=0.043 and p=0.011, respectively) and directly with incomplete spermatocytic maturation arrest and obstructive azoospermia (p=0.027 and p=0.013, respectively). FSH was only correlated with obstructive azoospermia (p=0.001).
Conclusion: We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies.
Objective: To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia.
Materials and Methods: This cross-sectional study was done during July 2006 to September 2007 on 41 patients with azoospermia. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients.
Results: Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal (p=0.001). Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome (p=0.043 and p=0.011, respectively) and directly with incomplete spermatocytic maturation arrest and obstructive azoospermia (p=0.027 and p=0.013, respectively). FSH was only correlated with obstructive azoospermia (p=0.001).
Conclusion: We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies.
Type of Study: Original Article |
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