Volume 22, Issue 5 (May 2024)                   IJRM 2024, 22(5): 375-382 | Back to browse issues page

Ethics code: IR.TUMS.IKHC.REC.1399.353


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Hantoushzadeh S, Amiri A, Shabani A, Soufi Enayati Y, Mostafaeipour N, Mousavi Vahed S H, et al . Short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status: A quasi-experimental observational (before-after) study. IJRM 2024; 22 (5) :375-382
URL: http://ijrm.ir/article-1-3190-en.html
1- Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
2- Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
3- Preventative Gynecology Research Center (PGRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4- Psychology Department, University of Science and Culture, Tehran, Iran.
5- Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran.
6- Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran.
7- Department of Gynecology, School of Medicine, Pasteur Hospital, Bam University of Medical Sciences, Bam, Iran.
8- Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. , toktamsheykhian@gmail.com
Abstract:   (396 Views)
Background: The administration of antenatal corticosteroid is a standard treatment to reduce the rate of perinatal mortality and morbidity; however, there is limited evidence regarding the potential effects of betamethasone on the constriction of the ductus arteriosus (DA).
Objective: This study aimed to investigate the short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status.
Materials and Methods: This quasi-experimental observational (before-after) study was conducted on 32 singleton fetuses. The participants were healthy pregnant women with a diagnosis of placenta accreta spectrum who were eligible for 2 doses of betamethasone and referred to prenatal care clinic, Vali-E-Asr hospital, Tehran, Iran from January 2021-May 2022. The results of fetal echocardiography and Doppler sonography were compared before and after the administration of antenatal corticosteroid therapy.
Results: Following betamethasone injection, significant increases were observed in peak systolic and diastolic velocity of the DA without constriction of the DA (p < 0.001, p = 0.002 respectively). However, no significant changes were observed in right ventricular function, tricuspid valve function, Doppler of ductus venous, and peak systolic velocity of the aortic isthmus (p > 0.05). Doppler examination of the uterine, umbilical, and middle cerebral arteries also showed no significant changes (p > 0.05).
Conclusion: Considering the benefits of antenatal corticosteroid therapy, its administration seems reasonable in preterm births. The transient changes in ductal blood flow are not prohibitive.
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Type of Study: Original Article | Subject: Perinatology

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