Volume 10, Issue 6 (4-2012)                   IJRM 2012, 10(6): 517-522 | Back to browse issues page

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Cyrus A, Solhi H, Azizabadi Farahani M, Khoddami Vishteh H R, Goudarzi D, Mosayebi G et al . The effect of opium dependency on testis volume: a case-control study. IJRM 2012; 10 (6) :517-522
URL: http://ijrm.ir/article-1-331-en.html
The effect of opium dependency on testis volume: a case-control study
Ali Cyrus1 , Hassan Solhi * 2, Mahdi Azizabadi Farahani3 , Hamid Reza Khoddami Vishteh3 , Davoud Goudarzi1 , Ghasem Mosayebi4 , Hamed Mohamadian5
1- Department of Urology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
2- Department of Toxicology and Forensic Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran , solhi2@yahoo.com
3- Arak University of Medical Sciences, Arak.Iran
4- Department of Microbiology and Immunology, Arak University of Medical Sciences, Arak, Iran
5- Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (11248 Views)
Background: Given the paucity of data on possible testis changes in opioid dependents, we sought to compare the testis volumes between a group of opium dependents and a group of healthy controls.
Objective: Comparison of testis volume between opium dependents and healthy controls.
Materials and Methods: This case-control study recruited 100 men with opium dependency (cases) and 100 healthy men (controls) in Iran, in 2008. A checklist containing questions about age, height, weight, daily amount of cigarette use, and duration of cigarette use for all the participants as well as daily amount of opium use (grams) and duration of opium use (years) for the case group was completed. Additionally, the dimensions of each testis were measured by a single person using calipers, and the mean of the left and right testes volume was compared between these two groups.
Results: The mean of the testis volumes in the case group was significantly lower than that of the case group (11.2±2.2 and 25.1±2.7cm³, p<0.001). The results of the ANCOVA test showed that even after the omission of the cigarette smoking effect (p=0.454), the testis volume remained lower in the opium dependents (R2=0.884, p<0.001). In the case group, there were significant reverse correlations between testis volume and age (r=-0.404, p<0.001), daily amount of opium use (r=-0/207, p=0.039) and duration of opium use (r=-0.421, p<0.001).
Conclusion: We found that the testis volume in the male opium dependents was lower than that of the healthy controls. We would recommend that future studies into the impact of drugs on the testis dimensions pay heed to possible histological changes in the testes owing to opium dependency.
Keywords: Testis volume, Male reproductive system, Opium, Cigarette
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