جمعه 14 اردیبهشت 1403
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دوره 4، شماره 1 - ( 4-1385 )
جلد 4 شماره 1 صفحات 39-35 |
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Dehghan M H, Dehghanan R. Plasma level of vitamin C in women with pre-eclampsia in Ardabil, Iran. IJRM 2006; 4 (1) :35-39
URL: http://ijrm.ir/article-1-43-fa.html
URL: http://ijrm.ir/article-1-43-fa.html
Plasma level of vitamin C in women with pre-eclampsia in Ardabil, Iran. International Journal of Reproductive BioMedicine. 1385; 4 (1) :35-39
چکیده: (2634 مشاهده)
Background: Pre-eclampsia, a vascular disorder of pregnancy, is a leading cause of maternal morbidity as well as perinatal morbidity and mortality. The cause of pre-eclampsia remains largely unknown. Accumulating evidences from clinical and epidemiological studies suggest that diffuse endothelial dysfunction, resulting from oxidative stress, plays an important role in the pathogenesis of pre-eclampsia. Independent effect of maternal biological markers, such as elevated triglyceride or low plasma vitamin C (ascorbic acid) concentrations are related to increased pre-eclampsia risk.
Objectives: The aim of this study was to determine plasma concentrations of vitamin C in women with pre-eclampsia.
Materials and Methods: This cross-sectional, case controlled study comprises 40 pre-eclamptic and 80 normo-tensive pregnant women of singleton gestations in third trimester, in Allavi Hospital, Ardabil, Iran. Blood samples (5ml) were collected aseptically in heparin tube, and the plasma concentration of vitamin C was determined by spectrophotometric method . SPSS software package was used for analyzing the data.
Results: Plasma vitamin C level was found to be significantly lower (p<0.001) in the pre-eclampsia group than this level in the control group. Vitamin C levels in the pre-eclampsia group were found to be influenced by their maternal age (p<0.01), and was positively related to the gestational age (p<0.01).
Conclusion: Knowledge from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of pre-eclampsia.
Objectives: The aim of this study was to determine plasma concentrations of vitamin C in women with pre-eclampsia.
Materials and Methods: This cross-sectional, case controlled study comprises 40 pre-eclamptic and 80 normo-tensive pregnant women of singleton gestations in third trimester, in Allavi Hospital, Ardabil, Iran. Blood samples (5ml) were collected aseptically in heparin tube, and the plasma concentration of vitamin C was determined by spectrophotometric method . SPSS software package was used for analyzing the data.
Results: Plasma vitamin C level was found to be significantly lower (p<0.001) in the pre-eclampsia group than this level in the control group. Vitamin C levels in the pre-eclampsia group were found to be influenced by their maternal age (p<0.01), and was positively related to the gestational age (p<0.01).
Conclusion: Knowledge from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of pre-eclampsia.
نوع مطالعه: Original Article |
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